Cytokine symphony: Deciphering the tumor microenvironment and metastatic axis in oral cancer [0.03%]
细胞因子交响曲：解码口腔癌的肿瘤微环境和转移轴
Mukesh Kumar Manickasamy,Ravichandran Vishwa,Bandari BharathwajChetty et al.
Mukesh Kumar Manickasamy et al.
Oral cancer remains one of the deadliest diseases due to its aggressive nature, high metastatic potential, and limited therapeutic success. The tumor microenvironment (TME) serves as a central regulator in the metastasis of oral cancer by s...
Neuroprotective properties of ciliary neurotrophic factor in the retina for the treatment of macular telangiectasia type 2 [0.03%]
睫状神经营养因子在视网膜中的神经保护特性可治疗黄斑 telangiectasia II型疾病
Arne Nystuen,Eugene Gonzalez-Lopez,Konrad A Kauper et al.
Arne Nystuen et al.
Neurotrophic factors are a family of proteins that promote the growth and survival of both developing and mature neurons. Extensive preclinical studies have demonstrated neuroprotective properties conferred by ciliary neurotrophic factor (C...
Exploring AI tools and multi-omics for precision medicine in lung cancer therapy [0.03%]
探索AI工具和多组学在肺癌治疗精确诊疗中的应用
Arvindra Sahu,Priyanshu Nema,Devraj Rajak et al.
Arvindra Sahu et al.
Lung cancer is a leading cause of cancer-related mortality worldwide, characterized by the uncontrolled growth and spread of abnormal cells. Despite constant progress in diagnosis and treatment of lung cancer remains highly challenging. Pre...
Targeting macrophage-directed pathological processes in pancreatic ductal adenocarcinoma: Mechanisms and targeted therapies [0.03%]
胰腺导管腺癌中针对巨噬细胞相关病理过程的机制及靶向治疗
Zhou Chen,Defeng Guan,Yan Wang et al.
Zhou Chen et al.
Macrophages support the malignant transformation of pancreatic ductal adenocarcinoma cells by secreting cytokines and enzymes, which enhance tumor invasiveness and metastatic potential. In addition to promoting tumor growth, macrophages con...
Metabolic Regulation of cGAS-STING Signaling in the Tumor Microenvironment: Dual Immune Roles and Therapeutic Implications [0.03%]
肿瘤微环境中cGAS-STING信号的代谢调节：双重免疫作用和治疗意义
Yong Wu,Wen-Min Lu,Qian-Ru Cui et al.
Yong Wu et al.
The cGAS-STING pathway, a cytosolic DNA-sensing mechanism, plays a context-dependent pivotal role in tumor immunity and tumor microenvironment (TME) remodeling. Acute activation of this pathway promotes type I interferon (IFN-I) and pro-inf...
The central role of CXCL10-CXCR3 signaling in neuroinflammation and neuropathology [0.03%]
CXCL10-CXCR3信号在神经炎症和神经病理中的核心作用
Alexandro A Bufi,Julia Di Stefano,Andrea Papait et al.
Alexandro A Bufi et al.
The role of neuroinflammation is becoming increasingly prominent as our understanding of the mechanisms underlying central nervous system disorders advances. What makes this phenomenon particularly intriguing from a clinical perspective is ...
Nuclear receptors in pulmonary hypertension: From pathophysiological mechanisms to clinical implications [0.03%]
核受体在肺动脉高压中的作用：从病理生理机制到临床意义
Tianxin Xiong,Yi Li,Hong Chen et al.
Tianxin Xiong et al.
Pulmonary hypertension is one of the most intractable cardiovascular diseases in the world today. The current pharmacological treatments can temporarily relieve symptoms, but the therapeutic effect is unsatisfactory in advanced pulmonary hy...
Exploring inflammatory and fibrotic mechanisms driving diabetic nephropathy progression [0.03%]
探索炎症和纤维化机制在糖尿病肾病进展中的作用
Zeeshan Ansari,Ayush Chaurasia,Neha et al.
Zeeshan Ansari et al.
Diabetic nephropathy (DN) remains a leading cause of end-stage renal disease, with inflammation and fibrosis serving as pivotal drivers of disease progression. Chronic hyperglycemia induces oxidative stress, activates immune pathways, and p...
Susanna G Ford,Patrick Caswell,David Brough et al.
Susanna G Ford et al.
Interleukin (IL)-1β is a pro-inflammatory cytokine largely produced by cells of the innate immune system in response to tissue damage or to the presence of pathogens. IL-1β-driven inflammation is an established contributor to many disease...
Dimitrios G Argyris,Dimitra P Anastasiadou,Panagiota S Filippou et al.
Dimitrios G Argyris et al.
The chemokine CXCL16, often termed "Swiss army knife chemokine," plays diverse roles in tumor biology through its dual existence as a transmembrane (mCXCL16) and a soluble (sCXCL16) form. Signaling exclusively through its receptor CXCR6, th...