Exploring inflammatory and fibrotic mechanisms driving diabetic nephropathy progression [0.03%]
探索炎症和纤维化机制在糖尿病肾病进展中的作用
Zeeshan Ansari,Ayush Chaurasia,Neha et al.
Zeeshan Ansari et al.
Diabetic nephropathy (DN) remains a leading cause of end-stage renal disease, with inflammation and fibrosis serving as pivotal drivers of disease progression. Chronic hyperglycemia induces oxidative stress, activates immune pathways, and p...
Susanna G Ford,Patrick Caswell,David Brough et al.
Susanna G Ford et al.
Interleukin (IL)-1β is a pro-inflammatory cytokine largely produced by cells of the innate immune system in response to tissue damage or to the presence of pathogens. IL-1β-driven inflammation is an established contributor to many disease...
Dimitrios G Argyris,Dimitra P Anastasiadou,Panagiota S Filippou et al.
Dimitrios G Argyris et al.
The chemokine CXCL16, often termed "Swiss army knife chemokine," plays diverse roles in tumor biology through its dual existence as a transmembrane (mCXCL16) and a soluble (sCXCL16) form. Signaling exclusively through its receptor CXCR6, th...
Wen Luo,Qingfeng Shi,Mingming Han et al.
Wen Luo et al.
The carcinogenesis and drug resistance can be accelerated by TGF-β, primarily by enhancing epithelial-mesenchymal transition (EMT). This review examines the complex mechanisms by which TGF-β drives EMT across different tumors, highlightin...
Efferocytosis at the frontline of homeostasis: Shaping the bone microenvironment and therapeutic implications in related diseases [0.03%]
吞噬细胞在稳态前线：塑造骨微环境及在相关疾病治疗中的意义
Liyile Chen,Ken Kadoya,Tsutomu Endo et al.
Liyile Chen et al.
Bone is a dynamic tissue that constantly undergoes remodeling processes throughout life to maintain its structure and integrity. During this process, physiological bone turnover, which is shaped by apoptosis, occurs in cells in the bone mic...
Tara Shammas,Malalage N Peiris,April N Meyer et al.
Tara Shammas et al.
The chromosomal translocation t(9;22)(q34;q11), known as the Philadelphia (Ph) chromosome, results in the BCR-ABL gene fusion which gives rise to Chronic Myeloid Leukemia (CML), a slowly progressing hematopoietic cancer that begins in the b...
Mechanisms underlying resistance to CAR-T cell therapy and strategies for enhancement [0.03%]
CAR-T细胞治疗的耐药机制及优化策略
Anran Wu,Tingying Zhang,Hongkai Yu et al.
Anran Wu et al.
Chimeric antigen receptor (CAR) T-cell therapy has emerged as a revolutionary approach in the treatment of hematological malignancies, including acute lymphoblastic leukemia, B-cell lymphoma, and multiple myeloma. Despite its promise, the c...
Xiaojing Zhang,Ruoqi Zheng,Leiliang Zhang
Xiaojing Zhang
NEDD4-binding protein 1 (N4BP1) is emerging as a critical regulator of inflammation and immune responses, particularly through its effects on the nuclear factor-κ-gene binding (NF-κB) signaling pathway. This review summarizes the regulato...
Decoding the neuroimmune axis in colorectal cancer: From neural circuitry to therapeutic innovation [0.03%]
结直肠癌神经免疫轴的解码：从神经环路到治疗创新
Ying Li,Sheng-Ya Yang,Ying-Ru Zhang et al.
Ying Li et al.
The nervous and immune systems are two major components that maintain body homeostasis, with their functional roles often overlapping significantly. Both systems are capable of identifying, integrating, and organizing responsive reactions t...
From immune activation to disease progression: Unraveling the complex role of Serum Amyloid A proteins [0.03%]
从免疫激活到疾病进展：揭开血清淀粉样蛋白A的作用复杂性
Praveen Papareddy,Heiko Herwald
Praveen Papareddy
Serum Amyloid A (SAA) proteins are critical mediators of immune activation and metabolic regulation, bridging the acute-phase response with long-term disease dynamics. Once considered mere biomarkers of inflammation, emerging research has r...