Reprogramming natural killer cells in the tumor microenvironment: Challenges and therapeuticopportunities [0.03%]
肿瘤微环境中的自然杀伤细胞重编程：挑战与治疗机会
Wenxue Ma,Sheldon Morris,Catriona Jamieson
Wenxue Ma
Natural killer (NK) cells are central effectors of innate immunity, traditionally viewed as rapid responders capable of recognizing and eliminating malignant or virus-infected cells without prior sensitization. Their combined capacity to me...
Targeting the NLRP3 inflammasome in sepsis: Molecular mechanisms and therapeutic strategies [0.03%]
调控NLRP3炎症小体治疗脓毒症：分子机制与治疗策略
Yuhui Ma,Jialei Meng,Fangyuan Sun et al.
Yuhui Ma et al.
Sepsis is a life-threatening organ dysfunction triggered by a dysregulated host response to infection, with immune homeostasis imbalance at the core of its pathological mechanism. The NACHT, leucin-rich repeat (LRR) and pyrin domain (PYD)-c...
Erratum to "TLR-Based therapeutic strategies for Hepatocellular carcinoma" [Cytokine Growth Factor Rev. Volume 85 2025 Pages 179-189] [0.03%]
关于“基于TLR的肝细胞癌治疗策略”的勘误[Cytokine Growth Factor Rev.卷85,2025,第179-189页]
Manoj Kumar Gupta,Ramakrishna Vadde
Manoj Kumar Gupta
Published Erratum
Cytokine & growth factor reviews. 2025 Sep 24:86:56. DOI:10.1016/j.cytogfr.2025.09.005 2025
Designing immunity with cytokines: A logic-based framework for programmable CAR therapies [0.03%]
基于细胞因子的免疫设计：用于可编程CAR治疗的逻辑基础框架
Saurabh Upadhyay,Kirti Upmanyu,Moustafa T Gabr
Saurabh Upadhyay
Adoptive cellular immunotherapy has transformed cancer care, with chimeric antigen receptor (CAR) T cells achieving unprecedented remission in hematologic malignancies. Yet solid tumor translation remains limited by antigen escape, hostile ...
Wiring and rewiring PANoptosis: Molecular vulnerabilities for targeting inflammatory cell death in human disease [0.03%]
重塑PANoptosis：人类疾病中炎症性细胞死亡的分子脆弱性和靶向治疗
Kirti Upmanyu,Saurabh Upadhyay
Kirti Upmanyu
PANoptosis represents a unified inflammatory cell death program that mechanistically integrates pyroptosis, apoptosis, and necroptosis through multiprotein complexes known as PANoptosomes. While prior models treated these death pathways as ...
Heat shock protein 70 (Hsp70) as a target for advancing immunotherapy in solid tumors [0.03%]
热休克蛋白70(Hsp70)作为实体瘤免疫治疗靶点的潜力
Khouloud Hachani,Mohamad Ghanem,A Graham Pockley et al.
Khouloud Hachani et al.
Heat shock protein 70 (Hsp70) is a highly conserved molecular chaperone that maintains protein homeostasis (proteostasis) under stress conditions. In cancer, Hsp70 is frequently overexpressed, where it contributes to hallmark features of ma...
Myokines and osteokines in aging-related degenerative diseases: Regulatory networks in the muscle-bone-brain axis [0.03%]
衰老相关退行性疾病中的肌肉因子和骨因子：肌骨脑轴中的调控网络
Shang Gao,Nianhu Li,Lijie Qi et al.
Shang Gao et al.
This review summarizes the biological properties of key myokines (Irisin, Apelin, CLCF1, and Myostatin) and osteokines (Osteocalcin, Sclerostin, FGF23 and the RANKL/OPG system). This work provides an in-depth analysis of the age-related net...
From senescence to scarring: Exploring TGF-β signaling in cellular aging, fibrotic remodeling, and pulmonary fibrosis [0.03%]
从衰老到瘢痕：探讨TGF-β信号转导在细胞衰老、纤维化重塑及肺纤维化中的作用
Shivani Bhardwaj,Rohit Kumar Gautam,Sapana Kushwaha
Shivani Bhardwaj
Cellular senescence and the formation of fibrotic scarring are critical in the progression of chronic illnesses, such as pulmonary fibrosis (PF). In this context, the transforming growth factor-beta (TGF-β) pathway represents a central dri...
Qianqian Li,Yuetong Li,Bo Zhang et al.
Qianqian Li et al.
Innate lymphoid cells (ILCs) are crucial components of the innate immune system that facilitate rapid responses to tissue homeostasis, infection, injury, and inflammation. Recent studies have shown that ILCs can migrate from intestinal tiss...
Cong Xie,Yuhan Lin,Cong Qi et al.
Cong Xie et al.
Metabolic homeostasis, essential for energy balance, is regulated by a highly integrated network involving the nervous, endocrine, and immune systems. While traditional models emphasized endocrine feedback mechanisms and autonomic nervous c...