From senescence to scarring: Exploring TGF-β signaling in cellular aging, fibrotic remodeling, and pulmonary fibrosis [0.03%]
从衰老到瘢痕：探讨TGF-β信号转导在细胞衰老、纤维化重塑及肺纤维化中的作用
Shivani Bhardwaj,Rohit Kumar Gautam,Sapana Kushwaha
Shivani Bhardwaj
Cellular senescence and the formation of fibrotic scarring are critical in the progression of chronic illnesses, such as pulmonary fibrosis (PF). In this context, the transforming growth factor-beta (TGF-β) pathway represents a central dri...
Qianqian Li,Yuetong Li,Bo Zhang et al.
Qianqian Li et al.
Innate lymphoid cells (ILCs) are crucial components of the innate immune system that facilitate rapid responses to tissue homeostasis, infection, injury, and inflammation. Recent studies have shown that ILCs can migrate from intestinal tiss...
Cong Xie,Yuhan Lin,Cong Qi et al.
Cong Xie et al.
Metabolic homeostasis, essential for energy balance, is regulated by a highly integrated network involving the nervous, endocrine, and immune systems. While traditional models emphasized endocrine feedback mechanisms and autonomic nervous c...
Manoj Kumar Gupta,Ramakrishna Vadde
Manoj Kumar Gupta
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a leading cause of cancer-related deaths worldwide. Chronic inflammation and immune dysregulation, often driven by viral infections or metabolic disorders, play a si...
Mechanisms and routes of G-protein coupled receptor-mediated Tau degradation in Alzheimer's disease [0.03%]
阿尔茨海默病中G蛋白偶联受体介导的Tau蛋白降解机制和途径
Vaishnavi Ananthanarayana,Hariharakrishnan Chidamabram,Periyasamy Govindaraj et al.
Vaishnavi Ananthanarayana et al.
Alzheimer's disease is the most prevalent form of dementia and major Tauopathies characterized by memory loss and cognitive decline. Important pathological features include extracellular build-up of amyloid-β peptides which form senile pla...
Cardiac and pericardial inflammatory changes and post-cardiac surgery atrial fibrillation [0.03%]
心脏和心包炎症变化与术后房颤的关系
Sophie Spicer,Amin Hasheminia,Sneha Kandi et al.
Sophie Spicer et al.
Postoperative atrial fibrillation (POAF) is one of the most common complications after cardiac surgery with an estimated incidence of up to 20-55 % of patients. POAF is associated with higher morbidity, prolonged hospital stays, and increas...
Role of growth factors and their interplay during oligodendroglial differentiation and maturation [0.03%]
生长因子及其在少突胶质细胞分化和成熟过程中的相互作用的作用
Shrey Dwivedi,Sneha Ranjan,Shuvajit Das et al.
Shrey Dwivedi et al.
Oligodendrocytes (OLs) facilitate the myelination within the central nervous system (CNS). Neuronal axons are originally devoid of myelin and acquire myelination during development. OLs are derived from oligodendrocyte precursor cells (OPCs...
Targeting cGAS-STING signaling and cell death modes in cancer and autoimmune diseases [0.03%]
靶向cGAS-STING信号通路和细胞死亡模式以治疗癌症和自身免疫性疾病
Jing Zhou,Yi Yang,Yaning Fang et al.
Jing Zhou et al.
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is an important component of innate immunity, involved in regulating various pathological conditions such as cancer, autoimmune and inflammatory dis...
Sergio Giunta,Angelica Giuliani,Jacopo Sabbatinelli et al.
Sergio Giunta et al.
Long COVID is a chronic condition that arises after SARS-CoV-2 infection and is characterized by persistent and often debilitating symptoms, such as fatigue, cognitive dysfunction ("brain fog"), dyspnea, and autonomic disturbances. Increasi...
Priya Solanki,Sushmita Jha
Priya Solanki
Epilepsy is a chronic, non-communicable neurological disease that affects more than 50 million people worldwide, making it one of the most common neurological diseases globally. Epilepsy is characterized by recurrent and unprovoked interrup...