Natural killers or natural regulators? Dual roles of NK cells in checkpoint immunotherapy [0.03%]
自然杀伤细胞的双重角色：免疫治疗的“双刃剑”
Wenxue Ma,Sheldon Morris,Catriona Jamieson
Wenxue Ma
Natural killer (NK) cells have long been recognized as central antitumor effectors capable of eliminating transformed cells without prior sensitization. However, recent studies reveal a more nuanced reality: NK cells can also act as regulat...
NK cell adaptation in the tumor microenvironment: Insights for NK cell-based immunotherapy [0.03%]
肿瘤微环境中NK细胞的适应性：基于NK细胞免疫疗法的新见解
Yaopeng Li,Yan Gao,Liangliang Wang et al.
Yaopeng Li et al.
Natural killer (NK) cells serve as critical first responders within the immune system, orchestrating antitumor responses by directly eliminating malignant cells and modulating broader immune functions. Their capacity to recognize stressed t...
SARS-CoV-2 innate immune recognition and implications for respiratory health [0.03%]
SARS-CoV-2的先天免疫识别及其对呼吸健康的影响
Vandana Anang,Pankaj Kumar,Jamaluddin Pracha et al.
Vandana Anang et al.
The ongoing global health impact of SARS-CoV-2, particularly on lung and respiratory health, underscores the critical need to decipher the intricate interplay between the virus and the host innate immune system. This review provides an anal...
Role of cytokine-based immunotherapy approaches in gastrointestinal cancers [0.03%]
细胞因子介导的免疫疗法在胃肠道肿瘤的应用及挑战
Rafik ElBeblawy,Midhun Malla,Mehmet Akce
Rafik ElBeblawy
Gastrointestinal (GI) cancers are among the most common leading causes of cancer-related mortality globally and they are the leading cause of cancer-related mortality in the US. Immune checkpoint inhibitor (ICI)-based therapies altered trea...
Targeting the colony-stimulating factor 1 axis for the treatment of Tenosynovial Giant Cell Tumors [0.03%]
靶向集落刺激因子1轴治疗滑膜巨细胞瘤
Paul Humbert,Charlotte Vialle,Marie Chevalerias et al.
Paul Humbert et al.
Diffuse and Localized Tenosynovial Giant Cell Tumors (D-/L-TGCT) are two closely related forms of benign tumors of the joint characterized by uncontrolled macrophage infiltration and proliferation. Both forms arise from similar translocatio...
Regulatory B cells: changing the landscape of immunoregulation and immunotherapy [0.03%]
调节性B细胞：重塑免疫调节和免疫治疗格局
Elina A Zheremyan,Nikolai R Kon,Alina S Ustiugova et al.
Elina A Zheremyan et al.
Recent advances in understanding regulatory B cells (Bregs) as critical modulators of immune homeostasis have opened new avenues for therapeutic intervention across a broad spectrum of immune-mediated diseases. Despite compelling preclinica...
Pancreatic cancer exosomes: Their role in drug resistance and immunomodulation [0.03%]
胰腺癌外泌体：其在耐药性及免疫调节中的作用
RamaRao Malla,Charanteja Mangam,Ganji Purnachandra Nagaraju
RamaRao Malla
Pancreatic ductal adenocarcinoma (PDAC) has a low survival rate, which is primarily attributed to its aggressive metastatic potential, poor prognosis, and the rapid development of resistance to conventional therapies. Within the PDAC microe...
Arteriolar angiogenesis: implications in anti-angiogenic immunotherapy for pancreatic cancers [0.03%]
胰腺癌抗血管生成免疫治疗的动脉血管生成意义
Adam W Beck,Herbert Chen,Bin Ren
Adam W Beck
Angiogenesis, the newly formed blood vessels from preexistent ones, is essential for the progression and potential resolution of diseases. Here we introduce a view of arteriolar angiogenesis (the growth of new small arteries), and define a ...
Reprogramming natural killer cells in the tumor microenvironment: Challenges and therapeuticopportunities [0.03%]
肿瘤微环境中的自然杀伤细胞重编程：挑战与治疗机会
Wenxue Ma,Sheldon Morris,Catriona Jamieson
Wenxue Ma
Natural killer (NK) cells are central effectors of innate immunity, traditionally viewed as rapid responders capable of recognizing and eliminating malignant or virus-infected cells without prior sensitization. Their combined capacity to me...
Targeting the NLRP3 inflammasome in sepsis: Molecular mechanisms and therapeutic strategies [0.03%]
调控NLRP3炎症小体治疗脓毒症：分子机制与治疗策略
Yuhui Ma,Jialei Meng,Fangyuan Sun et al.
Yuhui Ma et al.
Sepsis is a life-threatening organ dysfunction triggered by a dysregulated host response to infection, with immune homeostasis imbalance at the core of its pathological mechanism. The NACHT, leucin-rich repeat (LRR) and pyrin domain (PYD)-c...