Inflammatory mechanisms of preterm labor and emerging anti-inflammatory interventions [0.03%]
早产的炎症机制及抗炎干预措施研究进展
Tiffany Habelrih,Thalyssa-Lyn Augustin,Félix Mauffette-Whyte et al.
Tiffany Habelrih et al.
Preterm birth is a major public health concern, requiring a deeper understanding of its underlying inflammatory mechanisms and to develop effective therapeutic strategies. This review explores the complex interaction between inflammation an...
Quantitative and qualitative differences in the activation of a fibroblast growth factor receptor by different FGF ligands [0.03%]
不同FGF配体活化成纤维细胞生长因子受体的定量和定性差异
Mateusz A Krzyscik,Kelly Karl,Pooja Dudeja et al.
Mateusz A Krzyscik et al.
The FGF system is the most complex of all receptor tyrosine kinase signaling networks with 18 FGF ligands and four FGFRs that deliver morphogenic signals to pattern most embryonic structures. Even when a single FGFR is expressed in the tiss...
Gustav van Niekerk,Lotte Coelmont,Yeranddy A Alpizar et al.
Gustav van Niekerk et al.
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as semaglutide (Ozempic®), have emerged as effective treatments for diabetes and weight management. However, recent evidence indicates that GLP-1R signalling influences various tis...
The journey of STING: Guiding immune signaling through membrane trafficking [0.03%]
STING之旅：通过膜转运引导免疫信号转导
Jingyi He,Leiliang Zhang
Jingyi He
Stimulator of Interferon Genes (STING) serves as a pivotal mediator in the innate immune signaling pathway, transducing signals from various DNA receptors and playing a crucial role in natural immune processes. During cellular quiescence, S...
Deciphering the roles of the HMGB family in cancer: Insights from subcellular localization dynamics [0.03%]
解码HMGB家族在癌症中的作用：来自亚细胞定位动力学的见解
Junqing Jiang,Mengyu Sun,Yufei Wang et al.
Junqing Jiang et al.
The high-mobility group box (HMGB) family consists of four DNA-binding proteins that regulate chromatin structure and function. In addition to their intracellular functions, recent studies have revealed their involvement as extracellular da...
Fahad Hassan Shah,Heon-Woo Lee
Fahad Hassan Shah
The interactions between vascular cells, especially endothelial cells, and macrophages play a pivotal role in maintaining the subtle balance of vascular biology, which is crucial for angiogenesis in both healthy and diseased states. These c...
Sneha Kumari,Rishika Dhapola,Prajjwal Sharma et al.
Sneha Kumari et al.
Cerebral stroke is ranked as the third most common contributor to global mortality and disability. The involvement of inflammatory mechanisms, both peripherally and within the CNS, holds significance in the pathophysiological cascades follo...
The anti-inflammatory effects of itaconate and its derivatives in neurological disorders [0.03%]
衣康酸及其衍生物在神经性疾病中的抗炎效果
Xiangyi Kong,Lin Xu,Zheng Mou et al.
Xiangyi Kong et al.
Almost 16 % of the global population is affected by neurological disorders, including neurodegenerative and cerebral neuroimmune diseases, triggered by acute or chronic inflammation. Neuroinflammation is recognized as a common pathogenic me...
Unveiling the role of IL-17: Therapeutic insights and cardiovascular implications [0.03%]
IL-17的作用机制及其心血管效应和治疗价值
Kexin Jiang,Yanjiani Xu,Yan Wang et al.
Kexin Jiang et al.
Interleukin-17 (IL-17), a pivotal cytokine in immune regulation, has attracted significant attention in recent years due to its roles in various physiological and pathological processes. This review explores IL-17 in immunological context, ...
Glycosylation of FGF/FGFR: An underrated sweet code regulating cellular signaling programs [0.03%]
FGF/FGFR糖基化：一种被低估的调控细胞信号转导程序的重要修饰代码
Aleksandra Gędaj,Paulina Gregorczyk,Dominika Żukowska et al.
Aleksandra Gędaj et al.
Fibroblast growth factors (FGFs) and their receptors (FGFRs) constitute plasma-membrane localized signaling hubs that transmit signals from the extracellular environment to the cell interior, governing pivotal cellular processes like motili...