The immunopathogenesis of a cytokine storm: The key mechanisms underlying severe COVID-19 [0.03%]
细胞因子风暴的免疫病理ogenesis：严重COVID-19的关键机制
Luka Hiti,Tijana Markovič,Mitja Lainscak et al.
Luka Hiti et al.
A cytokine storm is marked by excessive pro-inflammatory cytokine release, and has emerged as a key factor in severe COVID-19 cases - making it a critical therapeutic target. However, its pathophysiology was poorly understood, which hindere...
Molecular regulation of mitophagy signaling in tumor microenvironment and its targeting for cancer therapy [0.03%]
肿瘤微环境中线粒体自噬信号的分子调控及其在癌症治疗中的靶向作用研究
Bishnu Prasad Behera,Soumya Ranjan Mishra,Srimanta Patra et al.
Bishnu Prasad Behera et al.
Aberrations emerging in mitochondrial homeostasis are restrained by mitophagy to control mitochondrial integrity, bioenergetics signaling, metabolism, oxidative stress, and apoptosis. The mitophagy-accompanied mitochondrial processes that o...
Interleukin-17: A pleiotropic cytokine implicated in inflammatory, infectious, and malignant disorders [0.03%]
白介素-17：一种与炎症、感染和肿瘤相关的多功能细胞因子
Anushka Saran,Daisuke Nishizaki,Scott M Lippman et al.
Anushka Saran et al.
IL-17A, referred to as IL-17, is the founding member of a family of pro-inflammatory cytokines, including IL-17B, IL-17C, IL-17D, IL-17E (or IL-25), and IL-17F, which act via receptors IL-17RA to IL-17RE, and elicit potent cellular response...
Interleukin-6 (IL-6)-associated tumor microenvironment remodelling and cancer immunotherapy [0.03%]
与白细胞介素6（IL-6）相关的肿瘤微环境重塑和癌症免疫治疗
Songsong Wu,Zhumin Cao,Rongying Lu et al.
Songsong Wu et al.
Interleukin-6 (IL-6) is a pro-inflammatory cytokine playing a pivotal role during inflammation and immune responses. In the recent years, the function of IL-6 in the tumor microenvironment (TME) for affecting tumorigenesis and immunotherapy...
Mechanisms coupling the mTOR pathway to chronic obstructive pulmonary disease (COPD) pathogenesis [0.03%]
构成mTOR信号通路与慢性阻塞性肺病(COPD)发病机制之间联系的分子机制研究进展
Ankita Goyal,Vishal Chopra,Kranti Garg et al.
Ankita Goyal et al.
Chronic Obstructive Pulmonary Disease (COPD) is a poorly reversible respiratory disorder distinguished by dyspnea, cough, expectoration and exacerbations due to abnormality of airways or emphysema. In this review, we consider the therapeuti...
Nuclear translocation of RON receptor tyrosine kinase. New mechanistic and functional insights [0.03%]
RON酪氨酸激酶受体的核转位 新的机制和功能见解
Yi-Lin Chen,Chien-An Chu,Jiu-Yao Wang et al.
Yi-Lin Chen et al.
Receptor tyrosine kinases (RTKs) are membrane sensors that monitor alterations in the extracellular milieu and translate this information into appropriate cellular responses. Epidermal growth factor receptor (EGFR) is the most well-known mo...
Granulocyte macrophage colony stimulating factor in virus-host interactions and its implication for immunotherapy [0.03%]
病毒-宿主相互作用中的粒细胞-巨噬细胞集落刺激因子及其在免疫治疗中的应用
Nasry Zane Bouzeineddine,Alecco Philippi,Katrina Gee et al.
Nasry Zane Bouzeineddine et al.
Viruses have evolved to strategically exploit cellular signaling pathways to evade host immune defenses. GM-CSF signaling plays a pivotal role in regulating inflammation, activating myeloid cells, and enhancing the immune response to infect...
LC3B: A microtubule-associated protein influences disease progression and prognosis [0.03%]
LC3B：一种微管相关蛋白影响疾病的进展和预后
Yan Chen,Hong Yi,Shan Liao et al.
Yan Chen et al.
Microtubule-associated protein 1 light chain 3B (MAP1LC3B, also known as LC3B) is a mammalian homolog of the autophagy-related protein 8 (ATG8) family. It plays a crucial role in cellular autophagy and is involved in several vital biologica...
Cytokine signalling in formation of neutrophil extracellular traps: Implications for health and diseases [0.03%]
细胞因子信号在中性粒细胞胞外陷阱形成中的作用：对健康和疾病的启示
Haritha Manoj,Sarah Michael Gomes,Pooja Yedehalli Thimmappa et al.
Haritha Manoj et al.
Neutrophils, as essential component of the innate immune response, form a crucial part in the defence mechanisms through the release of extracellular traps (NETs). These web-like structures, composed of chromatin and antimicrobial proteins,...
IL-33 in cancer immunotherapy: Pleiotropic functions and biological strategies [0.03%]
白细胞介素33在癌症免疫治疗中的多效功能及生物策略
Keying Che,Jinyu Li,Zheng Chen et al.
Keying Che et al.
Interleukin-33 (IL-33) belongs to the IL-1 cytokine superfamily and plays a critical role in regulating immune responses and maintaining host homeostasis. IL-33 is essential for driving and enhancing type 2 immune responses and is closely a...