Tara Shammas,Malalage N Peiris,April N Meyer et al.
Tara Shammas et al.
The chromosomal translocation t(9;22)(q34;q11), known as the Philadelphia (Ph) chromosome, results in the BCR-ABL gene fusion which gives rise to Chronic Myeloid Leukemia (CML), a slowly progressing hematopoietic cancer that begins in the b...
Mechanisms underlying resistance to CAR-T cell therapy and strategies for enhancement [0.03%]
CAR-T细胞治疗的耐药机制及优化策略
Anran Wu,Tingying Zhang,Hongkai Yu et al.
Anran Wu et al.
Chimeric antigen receptor (CAR) T-cell therapy has emerged as a revolutionary approach in the treatment of hematological malignancies, including acute lymphoblastic leukemia, B-cell lymphoma, and multiple myeloma. Despite its promise, the c...
Xiaojing Zhang,Ruoqi Zheng,Leiliang Zhang
Xiaojing Zhang
NEDD4-binding protein 1 (N4BP1) is emerging as a critical regulator of inflammation and immune responses, particularly through its effects on the nuclear factor-κ-gene binding (NF-κB) signaling pathway. This review summarizes the regulato...
Decoding the neuroimmune axis in colorectal cancer: From neural circuitry to therapeutic innovation [0.03%]
结直肠癌神经免疫轴的解码：从神经环路到治疗创新
Ying Li,Sheng-Ya Yang,Ying-Ru Zhang et al.
Ying Li et al.
The nervous and immune systems are two major components that maintain body homeostasis, with their functional roles often overlapping significantly. Both systems are capable of identifying, integrating, and organizing responsive reactions t...
From immune activation to disease progression: Unraveling the complex role of Serum Amyloid A proteins [0.03%]
从免疫激活到疾病进展：揭开血清淀粉样蛋白A的作用复杂性
Praveen Papareddy,Heiko Herwald
Praveen Papareddy
Serum Amyloid A (SAA) proteins are critical mediators of immune activation and metabolic regulation, bridging the acute-phase response with long-term disease dynamics. Once considered mere biomarkers of inflammation, emerging research has r...
Novel insights into neuroinflammatory mechanisms in traumatic brain injury: Focus on pattern recognition receptors as therapeutic targets [0.03%]
创伤性脑损伤中神经炎症机制的新见解——模式识别受体作为治疗靶点:focus
Harapriya Baral,Ravinder K Kaundal
Harapriya Baral
Traumatic brain injury (TBI) is a major global health concern and a leading cause of morbidity and mortality. Neuroinflammation is a pivotal driver of both the acute and chronic phases of TBI, with pattern recognition receptors (PRRs) playi...
John Hiscott
John Hiscott
Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy [0.03%]
肿瘤微环境中IL-6/JAK/STAT3信号的见解及其对癌症治疗的意义
Win Lwin Thuya,Yang Cao,Paul Chi-Lui Ho et al.
Win Lwin Thuya et al.
The IL-6/JAK/STAT3 signaling pathway is a key regulator of tumor progression, immune evasion, and therapy resistance in various cancers. Frequently dysregulated in malignancies, this pathway drives cancer cell growth, survival, angiogenesis...
The immunopathogenesis of a cytokine storm: The key mechanisms underlying severe COVID-19 [0.03%]
细胞因子风暴的免疫病理ogenesis：严重COVID-19的关键机制
Luka Hiti,Tijana Markovič,Mitja Lainscak et al.
Luka Hiti et al.
A cytokine storm is marked by excessive pro-inflammatory cytokine release, and has emerged as a key factor in severe COVID-19 cases - making it a critical therapeutic target. However, its pathophysiology was poorly understood, which hindere...
Molecular regulation of mitophagy signaling in tumor microenvironment and its targeting for cancer therapy [0.03%]
肿瘤微环境中线粒体自噬信号的分子调控及其在癌症治疗中的靶向作用研究
Bishnu Prasad Behera,Soumya Ranjan Mishra,Srimanta Patra et al.
Bishnu Prasad Behera et al.
Aberrations emerging in mitochondrial homeostasis are restrained by mitophagy to control mitochondrial integrity, bioenergetics signaling, metabolism, oxidative stress, and apoptosis. The mitophagy-accompanied mitochondrial processes that o...