Molecular mechanisms of biologic and targeted synthetic antirheumatic drugs in rheumatoid arthritis [0.03%]
生物制剂和靶向合成抗风湿药治疗类风湿性关节炎的分子机制
Longcan Li,Xin Chen,Shengpeng Wang et al.
Longcan Li et al.
Rheumatoid arthritis is sustained by a synovial cytokine network that acquires the capacity to maintain inflammation independently of its initiating stimulus. The biologic and targeted synthetic antirheumatic drugs developed over the past t...
Cytokine circuitries as determinants of response, resistance, and toxicity across cancer immunotherapy platforms [0.03%]
细胞因子回路决定各种癌症免疫治疗平台的反应、抗性和毒性
Arpita Mukherjee
Arpita Mukherjee
Cancer immunotherapy has substantially improved the management of solid tumors and hematologic malignancies; however, durable clinical benefit remains limited by primary and acquired therapeutic resistance, immune-related toxicities, and co...
The multifaceted roles of IL-1β in Alzheimer's disease: From pathogenic amplifier to neuroimmune modulator [0.03%]
白细胞介素-1β在阿尔茨海默病中的多种作用：从致病放大器到神经免疫调节剂
Dominika Pilat,Kévin Baranger,Santiago Rivera
Dominika Pilat
Alzheimer's disease (AD) is a progressive age-related neurodegenerative disorder and the most common form of dementia worldwide. Traditionally, its pathology has been defined by the presence of extracellular amyloid-beta (Aβ) plaques and i...
The role of tyrosine phosphorylation in modulating death receptor signaling [0.03%]
酪氨酸磷酸化在调节死亡受体信号转导中的作用
Pelin Dilsiz,Fatma Zehra Hapil
Pelin Dilsiz
Death receptors (DRs) are a subset of the tumor necrosis factor receptor (TNFR) superfamily with a protein interaction motif called the death domain. DRs, particularly TNFR1, FAS and TRAIL-Rs, mediate critical cellular outcomes, including a...
The role of cellular senescence in metabolic dysfunction-associated steatotic liver disease [0.03%]
细胞衰老在代谢功能紊乱相关肝脂肪变性疾病中的作用
Ruiming Wen,Haixia Wang,Jinli Xie et al.
Ruiming Wen et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, characterized by hepatic steatosis, inflammation, and progressive fibrosis. In recent years, cellular senesc...
Yunge Wang,Atikah Tsabita Muslihah,Mengwei Fu et al.
Yunge Wang et al.
Retinoids comprise vitamin A and its structurally related natural and synthetic derivatives. Retinoid dynamics involves multiple retinoid forms, carrier proteins, and enzymes that orchestrate the absorption, transport, storage and biotransf...
The functional roles of macrophage migration inhibitory factor in the tumor microenvironment [0.03%]
巨噬细胞迁移抑制因子在肿瘤微环境中的作用机制研究进展
Tingye Xu,Wenling Zhao,Wanjun Zha et al.
Tingye Xu et al.
Macrophage Migration Inhibitory Factor (MIF) is a structurally conserved yet functionally versatile cytokine that possesses enzymatic activity and can trigger downstream signaling through multiple receptors (such as CD74/CD44 and CXCR2/4/7)...
Tissue-resident immune cells in tumors: Cytokine-mediated regulation, functional plasticity, and therapeutic opportunities [0.03%]
组织驻留免疫细胞在肿瘤中的作用：细胞因子介导的调节、功能可塑性及治疗机会
Yijia Tang,Chenyu Hou,Ran Cao et al.
Yijia Tang et al.
Traditional tumor immunology research has predominantly focused on circulating recruited immune cells. In contrast, tissue-resident immune cells-a unique subset that stably resides in normal tissues and the tumor microenvironment (TME) for ...
Shared and context-specific mechanisms of T cell exhaustion in chronic viral infections and cancer: Transcriptional, metabolic, epigenetic, and therapeutic perspectives [0.03%]
慢性病毒感染和癌症中T细胞衰竭的共同机制及特定机制：转录、代谢、表观遗传及治疗观点
Wencan Zhang,Weifeng Yuan,Congli Yuan et al.
Wencan Zhang et al.
T cells are crucial for defending against viral infection and cancer by eliminating infected or transformed cells and establishing immune memory. However, persistent antigenic stimulation in chronic infections or tumors drives T cells into ...
Temporal dynamics of type I interferon signaling in checkpoint inhibitor response and resistance [0.03%]
I型干扰素信号在检查点抑制剂应答和耐药中的时相动态特征
Andrew Thake,Keith Sacco
Andrew Thake
While the long-term efficacy of checkpoint inhibition is established, the lack of response in IFN-rich tumors presents a critical challenge. These findings suggest that immune sensitivity depends on variables beyond cytokine levels and shou...