Role of FOXO3 in regulation of redox homeostasis and promotion of red blood cell longevity in sickle cell disease [0.03%]
FOXO3在调节红氧平衡及促进镰状细胞疾病红细胞长寿中的作用
Eluri Pavitra,Meenoo Kumbhakar,Byeongsu Kim et al.
Eluri Pavitra et al.
Sickle cell disease (SCD) is a severe monogenic red blood cell (RBC) disorder that follows a simple Mendelian mode of inheritance. SCD is characterized by hemoglobin S polymerization under deoxygenated conditions, leading to chronic hemolys...
Lipid metabolic reprogramming regulates macrophage senescence in the tumor microenvironment [0.03%]
脂质代谢重组可调节肿瘤微环境中巨噬细胞的衰老现象
Yixi Liu,Chenchi Li,Jiao Wang et al.
Yixi Liu et al.
Immune checkpoint inhibitors (ICIs) have made significant progress in the treatment of many malignant tumors; however, their efficacy remains limited by the complex immune-suppressive characteristics of the tumor microenvironment (TME), wit...
Cong Xie,Yuanyuan Ma,Yunjing Wang et al.
Cong Xie et al.
Pulmonary fibrosis is the common end-stage pathological outcome of diverse interstitial lung diseases (ILDs), defined by progressive alveolar structural destruction, aberrant extracellular matrix (ECM) deposition, and ultimately fatal respi...
Chemokines in thyroid cancer: Mechanistic insights and clinical implications [0.03%]
甲状腺癌中的趋化因子：机制见解与临床意义
Aleksandra Wiktoria Bratborska,Marek Ruchała
Aleksandra Wiktoria Bratborska
Thyroid cancer, the most prevalent endocrine malignancy, exhibits a diverse range of clinical behaviors, from indolent to highly aggressive phenotypes. Growing evidence indicates that chemokines, cytokines involved in the trafficking of leu...
Abdullah Altulea,Jamil Nehme,Marco Demaria
Abdullah Altulea
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that bridges innate immunity, cellular senescence and age‑related pathology. In this review, we describe the unique secretion mechanisms, compartment‑specific signalin...
Persistent spatial immune responses in glioblastoma following oncolytic virus therapy [0.03%]
肿瘤内溶瘤病毒治疗后的胶质母细胞瘤小鼠的持续空间免疫反应
Wenxue Ma,Teresa Sposito,Kendale Wirtjes et al.
Wenxue Ma et al.
Glioblastoma (GBM) remains highly resistant to immunotherapy due to limited T-cell infiltration and a profound immunosuppressive tumor microenvironment (TME). A recent first-in-human clinical trial of the oncolytic herpes simplex virus rQNe...
The intricate relationship between cytokines and galectins in immune modulation [0.03%]
细胞因子和半乳糖凝集素在免疫调节中的复杂关系
Shannah M Gennesse,Rory R Koenen,Victor L J L Thijssen
Shannah M Gennesse
The human immune system is a complex defense mechanism that protects the body against external and internal threats. Disruption of an effective immune response can lead to detrimental effects, such as autoimmune diseases or cancer. To ensur...
Therapeutic targeting of toll-like receptor pathways in tumor-associated macrophages [0.03%]
靶向肿瘤相关巨噬细胞中 Toll 样受体途径的治疗
Lei Wang,Yinghua Li,Zehua He et al.
Lei Wang et al.
Tumor-associated macrophages (TAMs) are central regulators of the tumor microenvironment (TME), shaping immune suppression, tumor progression, and therapeutic resistance. Toll-like receptors (TLRs) orchestrate innate immune activation and r...
Cytokine circuitry in pancreatic cancer: Targets for overcoming immune checkpoint inhibitor resistance in PDAC [0.03%]
胰腺癌中的细胞因子回路：克服免疫检查点抑制剂耐药性的PDAC靶点
Dhanisha Sulekha Suresh,Maria Fernanda Salcedo-Noriega,Utpreksha Vaish et al.
Dhanisha Sulekha Suresh et al.
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a poor prognosis due to its complex and highly immunosuppressive tumor microenvironment (TME). The PDAC TME, characterized by dense desmoplasia and enhanced infiltra...
Cytokine storm divergence in viral infections of the upper respiratory tract [0.03%]
呼吸道病毒感染中的细胞因子风暴分歧
Keda Chen,Qiuyi Xu,Jiaxuan Li et al.
Keda Chen et al.
Cytokine storm (CS) is a pathological state of dysregulated, hyperactive host immunity that arises in the context of infection, malignancy, or immunotherapy. CS is characterized by the sustained, markedly elevated release of multiple pro-in...