Knockout of nAChR subunits in spider mites and their phytoseiid predators confers spinosyn cross-resistance and reveals a conserved mode of action in mites [0.03%]
蜘蛛螨及其捕食性植绥螨中烟碱型乙酰胆碱受体亚基敲除引起甲氧虫酰肼类抗性和蜱螨目昆虫中作用机制保守性的揭示
Antonio Mocchetti,Pieter Steelant,Mahboubeh Hosseinkhani et al.
Antonio Mocchetti et al.
Spinosyns are allosteric modulators of nicotinic acetylcholine receptors (nAChRs) which in insects specifically target subunit α6. However, their mode of action in mites and compatibility with phytoseiid predators remain unclear. We combin...
Interaction of ML1 and SRB1-12 mediates cholesterol transport in the brown planthopper [0.03%]
ML1和SRB1-12的互作介导飞虱胆固醇转运
Xu Cheng,Yaxin Liu,Chenxu Zeng et al.
Xu Cheng et al.
Cholesterol transport plays a pivotal role in maintaining sterol homeostasis within eukaryotic cells. In mammals, Niemann-Pick Type C (NPC) proteins are known to participate in cholesterol transport. However, the precise pathways remain lar...
Morphogen-driven melanin pathway dynamics regulated by Wnt1 and apontic-like underlie larval spot coloration in Bombyx mori [0.03%]
家蚕幼虫色素斑颜色由形态发生素驱动的黑色素途径动力学决定，Wnt1和apo类似物通过调节该过程发挥作用
Shinichi Yoda
Shinichi Yoda
In insects, conspicuous larval pigmentation patterns serve critical ecological roles such as warning signals and mimicry, yet their underlying genetic regulation remains poorly understood. In this study, I investigated the molecular mechani...
Energy production is suppressed by vcircRNA_000048- bom-miR-2753-METTL20regulatoryaxis in the BmCPV-infected silkworm, Bombyx mori [0.03%]
BmCPV感染的家蚕能量产生受vcircRNA_000048-bom-miR-2753-METTL20调控轴抑制
Huilin Pang,Yuting Li,Min Zhu et al.
Huilin Pang et al.
VcircRNA_000048 is a viral circRNA (vcircRNA) derived from the region 164 - 1245 nt on the genomic dsRNA S5 segment (GQ294468.1) of Bombyx mori cytoplasmic polyhedrosis virus (BmCPV). Our previous studies indicated that BmCPV replication is...
Starvation induces a transition from autophagy to apoptosis via the ER-Ca2+-calpain signaling axis in the fat body of Bombyx mori [0.03%]
饥饿诱导家蚕脂肪体中的内质网钙蛋白酶信号轴介导的自噬向凋亡转变
Jialu Cheng,Sheng Zhang,Haoyi Gu et al.
Jialu Cheng et al.
Nutritional stress is a common environmental challenge for insects in nature. As a central organ of energy metabolism, the fat body plays a crucial role in maintaining energy homeostasis. However, the mechanisms by which the fat body regula...
NPF-OBP5 regulate sugar sensitivity and feeding behavior of rice planthoppers [0.03%]
蔗糖敏感性及飞虱取食行为的调控因子NPF-OBP5的研究
Ruichuan Duan,Yewei Jia,Xinru Xiao et al.
Ruichuan Duan et al.
Neuropeptide F (NPF) is considered to be related to the feeding behavior and odorant binding protein (OBP) is very important for the chemical perception of herbivorous insects to host plants, while, food sugar is a strong inducer for insect...
Trachealess, a bHLH-PAS transcription factor, is an upstream regulator of 20-hydroxyecdysone signaling essential for molting in Henosepilachna vigintioctopunctata [0.03%]
无气门是一个bHLH-PAS转录因子，是八斑瓢虫蜕皮过程中20E信号通路的上游调控因子
Junna Liu,Qi Chen,June-Sun Yoon et al.
Junna Liu et al.
The steroid hormone 20-hydroxyecdysone (20E) is the central regulator of insect molting, yet the upstream transcription factors controlling its pathway remain poorly characterized. Here, we investigate the role of the bHLH-PAS transcription...
DIL-CRISPR: a practical approach to mitigate G0 mosaic lethality in insect gene editing [0.03%]
用于缓解昆虫基因组编辑中G0嵌合体致死性的实用方法
Hiiragi Nishizawa,Takaaki Daimon
Hiiragi Nishizawa
Genome editing in insects is typically conducted by injecting genome editing reagents into early embryos, producing generation zero (G0) individuals that develop as genetic mosaics. Targeting genes whose disruption induces mosaic lethality ...
Collagen type XV regulation via MMP2-dependent degradation governs ovarian development in the Rice Stem Borer, Chilo suppressalis [0.03%]
稻纵卷叶螟卵巢发育中MMP2依赖性降解调控I型胶原蛋白XV的功能研究
Yue Li,Suijie Kuang,Yan Tang et al.
Yue Li et al.
Female reproductive development is fundamental to the remarkable reproductive capacity of insects, and extracellular matrix (ECM) remodeling plays a critical role in ovarian development. However, the function of Collagen, a major ECM compon...
TostOBP12 mediates the olfactory response to host volatiles in the parasitoid wasp Trichogramma ostriniae [0.03%]
托斯特OBP12介导寄生黄绒茧蜂对宿主挥发物的嗅觉反应
Xiang-Xin Kong,Hou-Xuan Zhang,Hong-Yu Liang et al.
Xiang-Xin Kong et al.
Trichogramma wasps are widely utilized as critical biological control agents in agricultural systems. Its efficacy relies on detecting host-derived chemical cues, yet the key molecular determinants underlying this process remain elusive. He...