Uptake of Ascaridia galli Extracellular Vesicles by Chicken Immune Cells varies according to worm sex and in vitro culture duration [0.03%]
鸡免疫细胞摄取Ascaridia galli胞外囊泡的情况因蠕虫性别和体外培养持续时间而异
Anna Sophia Feix,Konstantinos Papanikolaou,Rikke Brødsgaard Kjærup et al.
Anna Sophia Feix et al.
Ascaridia galli (A. galli), a parasitic roundworm that infects chickens poses an economic burden in poultry farming, as it causes ascaridiosis-a disease leading to reduced growth, lower egg production, and immunosuppression. Recently, inter...
Contrasting study designs reveal nuance in heterozygosity-parasite associations in the wild [0.03%]
相异的研究设计揭示了野外杂合子与寄生虫间的微妙联系
Katherine E L Worsley-Tonks,Stacey L Lance,Vanessa O Ezenwa
Katherine E L Worsley-Tonks
Heterozygosity-fitness correlations (HFCs) are widely used to explore the effects of inbreeding in wild populations. However, the biological significance of HFCs has been the subject of intense debate, and it has been suggested that the mag...
Development and validation of an explainable prediction model for schistosomiasis seropositivity: a population-based screening study in Hunan Province, China [0.03%]
中国湖南省基于人群的血清筛查研究中schistosomiasis阳性预测模型的构建及验证
Yu Zhou,Ling Tang,Mao Zheng et al.
Yu Zhou et al.
Early identification of people at risk of schistosomiasis infection is critical to interrupting disease transmission. We develop and validate an explainable machine learning prediction model that integrates demographic, behavioral, and envi...
Mining natural history collections for molecular treasures: mitogenomes and nuclear ribosomal transcription units of proteocephalid tapeworms (Onchoproteocephalidea) via genome skimming [0.03%]
从自然历史收藏中挖掘分子宝藏：通过基因组测序获取圆叶科绦虫（圆叶科）的线粒体基因组和核转录单位
Philippe Vieira Alves,Reinaldo José da Silva,Daniel Janies et al.
Philippe Vieira Alves et al.
The potential of natural history collections to address biological questions has been increasingly recognized with the advent of high-throughput sequencing (HTS) and museomics approaches. However, their use remains largely underexplored for...
Genetic diversity of Plasmodium falciparum equilibrative nucleoside transporters PfENT1 and PfENT4: Implications for purine-based antimalarial drug development [0.03%]
恶性疟原虫嘧啶转运蛋白PfENT1和PfENT4的遗传多样性对基于嘌呤的抗疟药物研发的影响
Worlanyo Tashie,Harry P de Koning,Nancy O Duah-Quashie et al.
Worlanyo Tashie et al.
The emergence and spread of Plasmodium falciparum resistance to current antimalarial drugs underscores the urgent need for new therapies with novel mechanisms of action and broad therapeutic potential. The purine salvage pathway in P. falci...
Parasites suffer too: Effects of host's pollutant exposure on some life-history traits of acanthocephalan parasites [0.03%]
宿主污染物暴露对旋毛纲寄生虫某些生活史特征的影响
Léa Lorrain-Soligon,Simon Agostini,Alexandre Bauer et al.
Léa Lorrain-Soligon et al.
Parasites are integral components of biodiversity, shaping host populations, food web dynamics, and ecosystem stability. However, they are influenced by environmental conditions and face growing threats. Despite growing evidence of global d...
Lessons on multicellular two- (2D) and three-dimensional (3D) culture in parasitology: Insights, challenges and future directions [0.03%]
虫害学中多细胞二维和三维培养的经验教训：见解、挑战与未来方向
David Smith,Matias G Perez,Miriam E Garner et al.
David Smith et al.
Advances in multicellular two-dimensional (2D) and three-dimensional (3D) cell culture systems are providing parasitologists with new tools to investigate host-parasite interactions in vitro. These models offer tissue-specific and, increasi...
Developing vaccines against gastrointestinal nematodes of sheep - The model matters [0.03%]
针对绵羊胃肠道线虫疫苗的研发-模型的选择很重要
Alasdair J Nisbet,Daniel R G Price,Yvonne Bartley et al.
Alasdair J Nisbet et al.
Different parasite challenge models have been used over many years in the development of novel vaccines against gastrointestinal nematodes of livestock. Typically, following vaccination with either native or recombinant proteins, the host a...
Genetic Signatures of Plasmodium vivax Circumsporozoite Surface Protein During Malaria Resurgence in Thailand [0.03%]
泰国疟疾流行期间Plasmodium vivax配子体表面蛋白的遗传特征分析研究
Parsakorn Tapaopong,Aurel Holzschuh,Gustavo da Silva et al.
Parsakorn Tapaopong et al.
The Plasmodium circumsporozoite surface protein (CSP) is the best characterized pre-erythrocytic vaccine target for malaria. It is a multifunctional protein important for sporozoite mobility, mosquito salivary gland invasion, and hepatocyte...
Andreu Saura,Vilém Blahout,Edubiel A Alpizar-Sosa et al.
Andreu Saura et al.
Callunene, a natural component of heather (Calluna vulgaris) nectar, has previously been shown to protect bumblebees from infection by the trypanosomatid Crithidia bombi. Here, we demonstrate that callunene exhibits antiparasitic activity a...