Complete mitochondrial genomes of eight cyclophyllidean tapeworms: genome pattern and phylogenetic analysis [0.03%]
八种假叶目绦虫线粒组基因组模式及系统进化分析
Ya-Hui Li,Yi-Liu Liu,Ya Zhang et al.
Ya-Hui Li et al.
Cyclophyllidean tapeworms are widespread parasites of significant medical and veterinary importance. However, mitochondrial (mt) genomic resources for cyclophyllideans from China, particularly those recovered from wildlife hosts, remain com...
Whole-exome characterization of host genetic variation in HIV-associated genes across the high-prevalence Mizo population, Northeast India [0.03%]
全外显子组特征描述HIV相关基因在高流行米佐人群中的宿主遗传变异情况（印度东北部）
Saurav Roy,K Lalrintluanga,Lalengkimi Ralte et al.
Saurav Roy et al.
Background: The Mizoram state of Northeast India has one of the highest HIV prevalence rates in Asia, yet the host genetic factors influencing HIV susceptibility in this Tibeto-Burman population remain uncharacterised. ...
Clinical and genetic analysis of Liver-Predominant ornithine transcarbamylase deficiency caused by a novel de novo OTC sequence variant in a female child [0.03%]
一种新的肝型鸟氨酸转甲酰酶缺乏症变异的临床及基因分析
An-Kang Zhu,Shi-Ni Cai,Chun-Hui Hu et al.
An-Kang Zhu et al.
Ornithine transcarbamylase deficiency (OTCD) is the most common urea cycle disorder. Although the classical presentation is dominated by hyperammonemia-related neurological manifestations, some patients may present with atypical liver-predo...
The single nucleotide polymorphism rs12041948 influences CDX4-Mediated RGS4 gene expression [0.03%]
单核苷酸多态性rs12041948通过CDX4调控RGS4基因表达
Feng-Ling Xu,Xin-Rui Yang,Yan-Yan Yang et al.
Feng-Ling Xu et al.
Background: The SNPs in the 5' regulatory region of the human RGS4 gene were reportedly associated with schizophrenia risk. Methods: To...
Deciphering the tomato defense network againstHelicoverpa armigera: From transcriptional reprogramming to biochemical changes [0.03%]
解码番茄对棉铃虫的防御网络：从转录重塑到生化变化
Muhammad Wajid Javed,Jam Nazeer Ahmad,Samina Tanwir et al.
Muhammad Wajid Javed et al.
Helicoverpa armigera (Hübner) is able to feed on more than 280 host plants; however, the mechanisms that allow it to persist on such a wide range of hosts may involve transcriptional reprogramming and biochemical alternations which are sti...
Development of green nematicides targeting a repressor of gonad mitosis in Bursaphelenchus xylophilus [0.03%]
针对松材线虫生殖细胞有丝分裂阻遏蛋白的绿色杀线剂研发
Wenxin Hu,Miao Su,Hudie Shao et al.
Wenxin Hu et al.
Background: Bursaphelenchus xylophilus is a worldwide quarantine pest that causes serious damage to the ecological security of pine trees worldwide. However, the mechanisms involved in mitosis and gamete formation of B. x...
Association between heavy metal exposure and epigenetic modifications in patients with urinary bladder cancer [0.03%]
重金属暴露与尿路膀胱癌患者表观遗传修饰的关系
Ganesh Kumar Verma,Deepika Saini,Pankaj Kumar Chaudhary et al.
Ganesh Kumar Verma et al.
Chronic exposure to heavy metals and occupational hazards is positively associated with carcinogenesis, although the underlying mechanisms remain poorly understood. The present study evaluated the association between heavy metal exposure an...
Screening and functional characterization of R2R3-MYB transcription factors regulating anthocyanin biosynthesis in lotus (Nelumbo nucifera) [0.03%]
莲子叶中调控花青素生物合成的R2R3-MYB转录因子的筛选及功能鉴定
Jingdi Wan,Jiangyuan Sheng,Di Zhang
Jingdi Wan
Anthocyanin biosynthesis is a key process determining flower color in lotus. In this study, 145 MYB transcription factors were identified from the lotus genome, of which 124 belong to the R2R3-MYB subfamily. Based on phylogenetic analysis a...
METTL7B promotes cell proliferation and metastasis in gastric cancer via PI3K/Akt signaling pathway [0.03%]
METTL7B通过PI3K/Akt信号通路促进胃癌细胞增殖和转移
Tao Wang,Beibei Ge,Chang Liu et al.
Tao Wang et al.
Background: Methyltransferase-like 7B (METTL7B) is a Golgi-associated methyltransferase linked to malignant progression of multiple tumors. However, its specific role and underlying mechanisms in gastric cancer remain unc...
Targeting PSMB2 suppresses glioblastoma progression and sensitizes tumors to temozolomide by modulating PTEN/PI3K/AKT pathway [0.03%]
靶向PSMB2可抑制胶质母细胞瘤的进展并调节PTEN/PI3K/AKT通路使肿瘤对替莫唑胺敏感
ZiLong Tan,Xiaolong Tang,Zhuo Chen et al.
ZiLong Tan et al.
Glioblastoma multiforme (GBM), a highly aggressive primary brain malignancy, is characterized by its accelerated development, refractoriness to therapy, and dismal prognosis. The proteasome subunit β2 (PSMB2), a catalytic unit of the 20S p...