NIPSNAP3B elevates mitochondrial biogenesis to attenuate lipid accumulation in childhood obesity via AMPK pathway [0.03%]
NIPSNAP3B通过AMPK信号通路提高线粒体生物合成以减轻儿童肥胖相关脂质蓄积
Kaifeng Li,Mengran Wang,Yanhong Liu et al.
Kaifeng Li et al.
Objective: Childhood obesity (CO) has become a global epidemic, leading to rising burden of many diseases and premature death. Thus, this study was conducted to screen the mitochondria-associated biomarkers for patients w...
YTHDC2-mediated RAB20 degradation regulates NLRP3 inflammasome priming to improve chronic glomerulonephritis [0.03%]
YTHDC2介导的RAB20降解调节NLRP3炎性小体启动以改善慢性肾小球肾炎
Yong Yan Tang,Ya Chen Gao,Tao Liu et al.
Yong Yan Tang et al.
Background: Chronic glomerulonephritis (CGN) primarily arises from immune-mediated inflammation, but the exact targets driving its initiation and progression remain unclear. This study identified the YTHDC2/RAB20/NLRP3 ax...
Genome-wide identification of the rosaceae bHLH gene family and functional characterization of PybHLH182 involved in stone cell formation in pear [0.03%]
蔷薇科bHLH基因家族的全基因组鉴定及PybHLH182参与梨石细胞形成的功能分析
Wei Wei,Yueyuan Liu,Chong Pan et al.
Wei Wei et al.
Basic helix-loop-helix (bHLH) transcription factors play central regulatory roles in plant development and responses to environmental stress. However, the evolutionary dynamics of the bHLH gene family in Rosaceae fruit species remain largel...
Small extracellular vesicles carrying miRNA34 in Alzheimer's disease: effects on oxidative stress, neuroinflammation, cognitive function, and mitochondrial/ferroptosis-related protein regulation [0.03%]
阿尔茨海默病中小细胞外囊泡介导的miRNA34对氧化应激、神经炎症、认知功能和线粒体/铁死亡相关蛋白表达的影响研究
Hamit Çelik,Oğuz Çelik,Şeyma Aydın et al.
Hamit Çelik et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, oxidative stress, and persistent neuroinflammation. Recent studies have increasingly focused on the regulatory role of microRNAs in AD ...
Emerging role of NEAT1 in skin pathology: from molecular regulation to clinical applications [0.03%]
NEAT1在皮肤病学中作用的研究进展：从分子调控到临床应用
Saadi Wiam,Fatmi Ahlam,Ameur Auda et al.
Saadi Wiam et al.
Long non-coding RNAs (lncRNAs) are increasingly recognized as crucial regulators of gene expression, influencing a wide array of physiological and pathological processes. Among these, Nuclear Enriched Abundant Transcript 1 (NEAT1), an essen...
Identification and functional analysis of biallelic loss-of-function variants of WNT7B in a Chinese family affected with PDAC syndrome [0.03%]
WNT7B 双等位基因失活变异导致胰管异常发育综合征的机制研究
Liyan Qiu,Caisheng Xu,Renhua Lu et al.
Liyan Qiu et al.
WNT7B-related pulmonary hypoplasia, diaphragmatic anomalies, anophthalmia/microphthalmia, and cardiac defects (PDAC) syndrome is rarely reported. To date, only two each nonsense and missense variants of WNT7B were identified in five pedigre...
The rye photoreceptor ScphyB integrates light signals to control development and architecture in Arabidopsis thaliana [0.03%]
大麦光受体ScphyB在拟南芥中整合光信号以控制发育和株型
Mengdan Ning,Yankun Li,Luhao Yang et al.
Mengdan Ning et al.
As an important food and feed crop, cultivated rye (Secale cereale L.) exhibits excellent resistance to biotic and abiotic stresses, making it a valuable genetic resource for wheat improvement. However, the functions of phytochromes in rye ...
Next-generation sequencing as an applicable method: from technical basis to use in medical diagnosis [0.03%]
下一代测序技术及其在医学诊断中的应用：从理论基础到临床实践
Arman Moradi,Mina Mousavi,Majid Maleki et al.
Arman Moradi et al.
Next-generation sequencing (NGS) is a high-throughput technology capable of determining the sequence of nucleotides in the genome. Over the past few years, the advent of NGS-based methods has provided timely and economical approaches for di...
Genetic diversity and genome-wide association mapping for salt stress tolerance in diverse parental lines of hybrid rice [0.03%]
水稻多样性亲本群体的耐盐性状的遗传变异及全基因组关联分析
Md Ruhul Quddus,M Akhlasur Rahman,Mehfuz Hasan et al.
Md Ruhul Quddus et al.
Salinity, exacerbated by climate change, is a major threat to rice production. Seedling biomass under salt stress is one of the key indicators of salinity tolerance. This is the first study that involved 276 diverse hybrid rice parental lin...
No evidence for the LRRK2 p.L1795F variant in a Southern Italian cohort with Parkinson's disease [0.03%]
LRRK2 p.L1795F变异不是南意大利帕金森病患者的致病因素
Monica Gagliardi,Radha Procopio,Alessia Felicetti et al.
Monica Gagliardi et al.
Background: Pathogenic variants in the LRRK2 gene are among the most common genetic causes of autosomal dominant Parkinson's disease (PD). A recent study provided strong genetic and functional evidence supporting the path...