Ushashi Ain,Y Rishabh,Hena Firdaus
Ushashi Ain
Integrins are conserved cell-adhesion receptors implicated in development and disease, including joint disorders and osteoarthritis. Unlike humans, which encode 18 α- and 8 β-subunits, Drosophila melanogaster carries only 5 α- and 2 β-i...
Interplay of βPS and βν integrins in Drosophila muscle functioning [0.03%]
βPS和βν整联蛋白在果蝇肌肉中的相互作用及其功能效应
Ushashi Ain,Y Rishabh,Hena Firdaus
Ushashi Ain
Integrins are conserved cell-adhesion receptors implicated in development and disease, including joint disorders and osteoarthritis. Unlike humans, which encode 18 α- and 8 β-subunits, Drosophila melanogaster carries only 5 α- and 2 β-i...
Targeting the gut-joint axis: Ferrostatin-1 alleviates Collagen-Induced arthritis and is associated with alterations in microbiota-derived metabolites [0.03%]
靶向肠道-关节轴：Ferrostatin-1可改善胶原诱导的关节炎并改变微生物群来源的代谢产物
Sijia Niu,Xiaoying Zhu,Juan Zhang et al.
Sijia Niu et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial inflammation and progressive bone destruction. While ferroptosis has recently been implicated in RA pathogenesis, the mechanisms linking ferroptosis inhibi...
Antagonistic regulation by mango MiSPL9a and MiSPL9b regulates flowering time, drought and salt stress in Arabidopsis [0.03%]
芒果MiSPL9a和MiSPL9b通过拮抗调节调控开花时间、干旱和盐胁迫
Yanshu Meng,Xiuxia He,Siyuan He et al.
Yanshu Meng et al.
SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) transcription factors, which are unique to plants, contain a highly conserved SBP domain that regulates gene expression by binding to downstream targets. They play critical roles in various biolo...
Integrative single‑cell and bulk transcriptomic profiling reveals MMP1 as a core effector and CTSB as a putative collaborator in ATBC‑aggravated pulmonary fibrosis [0.03%]
整合单细胞和批量转录组分析揭示了MMP1是ATBC加重的肺纤维化的核心效应物，CTSB可能是合作者
Dajia Fu,Xiuxiu Ding,Xinyi Cai et al.
Dajia Fu et al.
Background: Acetyl tributyl citrate (ATBC) is a widely used environmentally friendly plasticizer, and exposure via the respiratory tract is common in the general population. However, its pulmonary toxicity and underlying ...
A novel PKHD1 missense variant disrupting splicing in a fetus with Caroli disease [0.03%]
PKHD1错义突变干扰剪接导致胎儿Caroli病的一种新变异型
Hui Huang,Chen Cheng,Peiwen Chen et al.
Hui Huang et al.
Background: Caroli disease (CD) is a rare inherited disorder characterized by dilatation of intrahepatic bile ducts, and prenatal diagnosis of this disease is extremely rare. PKHD1 is the only known causative gene, yet th...
An oxidative stress - and immunotherapy-related six-gene signature defines immune subtypes and predicts prognosis and immunotherapy response in hepatocellular carcinoma [0.03%]
一种与氧化应激和免疫治疗相关的六基因特征可定义肝细胞癌的免疫亚型并预测预后和免疫治疗反应
Yuxin Liang,Xing Chen,Yuhao Su et al.
Yuxin Liang et al.
Background: Oxidative stress and the tumor immune microenvironment jointly shape hepatocellular carcinoma (HCC) progression and response to immunotherapy, yet integrated biomarkers linking these processes are lacking. ...
Identification of CD55 as a downstream factor of EP4 receptor signaling in colorectal cancer cells [0.03%]
识别CD55为EP4受体信号传导在结直肠癌细胞的下游因素
Keijo Fukushima,Isamu Konishi,Ayaka Hamaguchi et al.
Keijo Fukushima et al.
Prostaglandin E2 (PGE2) signaling through the E-type prostanoid 4 (EP4) receptor has been implicated in the pathophysiology of colorectal cancer (CRC). We herein identified decay-accelerating factor, also known as CD55, as a novel CRC-assoc...
LcRAV2 regulates drought resistance in litchi (Litchi chinensis Sonn) through a potential LcSnRK1-mediated phosphorylation [0.03%]
LCRAV2通过潜在的LCSnRK1介导的磷酸化调节荔枝的抗旱性
Yongkang Nong,Zhen Tao,Shilan Xu et al.
Yongkang Nong et al.
Drought stress severely affects the flowering and fruit set of litchi, while the molecular mechanism of the RAV transcription factor in litchi drought resistance remains unclear. In this study, we systematically evaluated the leaf drought t...
A novel tRNA-derived small RNA tsRNA-Ile-5-0044 is a candidate biomarker for laryngeal squamous cell carcinoma [0.03%]
新型tRNA衍生的small RNA tsRNA-Ile-5-0044可能是喉部鳞状细胞癌的生物标志物
Chuan-Jin Ding,Yan-Hong Zhang,Ying Zhang et al.
Chuan-Jin Ding et al.
tRNA-derived small RNAs (tsRNAs) have emerged as pivotal regulators and promising biomarkers in multiple malignancies, however their functional roles and clinical significance in HNSCC remain incompletely elucidated. Here, we found tsRNA-Il...