Inflammatory response toward a Mg-based metallic biomaterial implanted in a rat femur fracture model [0.03%]
镁基金属生物材料植入rats股骨骨折模型中的炎症反应
Sana Riyaz,Yu Sun,Heike Helmholz et al.
Sana Riyaz et al.
The immune system plays an important role in fracture healing, by modulating the pro-inflammatory and anti-inflammatory responses occurring instantly upon injury. An imbalance in these responses can lead to adverse outcomes, such as non-uni...
Tunneling nanotubes mediate KRas transport: Inducing tumor heterogeneity and altering cellular membrane mechanical properties [0.03%]
纳米管介导KRAS运输：诱导肿瘤异质性和改变细胞膜机械特性
Yawen Zheng,Jiangtao Li,Dadi Xu et al.
Yawen Zheng et al.
Mutation in oncogene KRas plays a crucial role in the occurrence and progression of numerous malignant tumors. Malignancy involves changes in cell mechanics for extensive cellular deformation during metastatic dissemination. We hypothesize ...
A 3D bioreactor model to study osteocyte differentiation and mechanobiology under perfusion and compressive mechanical loading [0.03%]
一种三维生物反应器模型用于研究灌注和受压状态下力学信号诱导的成骨细胞分化及其机制生物学效应
Wyonna Darleen Rindt,Melanie Krug,Shuntaro Yamada et al.
Wyonna Darleen Rindt et al.
Osteocytes perceive and process mechanical stimuli in the lacuno-canalicular network in bone. As a result, they secrete signaling molecules that mediate bone formation and resorption. To date, few three-dimensional (3D) models exist to stud...
IL-1ra loaded chondroitin sulfate-functionalized microspheres for minimally invasive treatment of intervertebral disc degeneration [0.03%]
负载 IL-1ra 的硫酸软骨素功能化微球的微创椎间盘退变治疗体系
Youzhi Hong,Yudong Duan,Zhuang Zhu et al.
Youzhi Hong et al.
Presently, the clinical treatment of intervertebral disc degeneration (IVDD) remains challenging, but the strategy of simultaneously overcoming the overactive inflammation and restoring the anabolic/catabolic balance of the extracellular ma...
Injectable, degradable, and mechanically adaptive hydrogel induced by L-serine and allyl-functionalized chitosan with platelet-rich plasma for treating intrauterine adhesions [0.03%]
L-丝氨酸和 allyl 功能化壳聚糖诱导的可注射、可降解和机械适应性水凝胶结合富血小板血浆治疗宫腔粘连
Hongyi Lv,Ruijuan Xu,Xiangyan Xie et al.
Hongyi Lv et al.
The integration of barrier materials with pharmacological therapy is a promising strategy to treat intrauterine adhesions (IUAs). However, most of these materials are surgically implanted in a fixed shape and incongruence with the natural m...
Antibacterial tellurium-containing polycarbonate drug carriers to eliminate intratumor bacteria for synergetic chemotherapy against colorectal cancer [0.03%]
抗菌碲改性聚碳酸酯载药体系协同化疗根除结直肠癌瘤内菌群
Jieni Hu,Shujun Ran,Zhengwei Huang et al.
Jieni Hu et al.
Intratumor microbes have attracted great attention in cancer research due to its influence on the tumorigenesis, progression and metastasis of cancer. However, the therapeutic strategies targeting intratumoral microbes are still in their in...
Structure, mechanical and adhesive properties of the cellulosic mucilage in Ocimum basilicum seeds [0.03%]
罗勒属种子的纤维素粘液结构、力学性能及黏附性研究
Helen Gorges,Alexander Kovalev,Stanislav N Gorb
Helen Gorges
Plant seeds and fruits, like those of Ocimum basilicum, develop a mucilaginous envelope rich in pectins and cellulosic fibers upon hydration. This envelope promotes adhesion for attachment to soils and other substrates for dispersal and pro...
Discovering 3D hidden elasticity in isotropic and transversely isotropic materials with physics-informed UNets [0.03%]
基于物理信息的UNet在各向同性和横向各向异性材料中发现三维隐弹性
Ali Kamali,Kaveh Laksari
Ali Kamali
Three-dimensional variation in structural components or fiber alignments results in complex mechanical property distribution in tissues and biomaterials. In this paper, we use a physics-informed UNet-based neural network model (El-UNet) to ...
Polypeptide nanoparticles conjugated with an NIR-II organic dye for TRPV1 channel blockade enhance mild phototheranostics [0.03%]
用于阻断TRPV1通道的近红外II有机染料偶联多肽纳米颗粒增强轻度光疗诊断疗法
Yating Wang,Changchang Teng,Yixuan Xu et al.
Yating Wang et al.
Photothermal therapy (PTT) has attracted attention as a highly effective non-invasive treatment method. However, the high localized temperatures (>50 °C) required for its treatment will inevitably cause damage to the surrounding normal tis...
Laura A Milton,Jordan W Davern,Luke Hipwood et al.
Laura A Milton et al.
Decellularized extracellular matrix (dECM) hydrogels provide tissue-specific microenvironments which accommodate physiological cellular phenotypes in 3D in vitro cell cultures. However, their formation hinges on collagen fibrillogenesis, a ...