High-performance electrically responsive artificial muscle materials for soft robot actuation [0.03%]
用于软机器人驱动的高性能电气响应人造肌肉材料
Liang Yang,Hong Wang
Liang Yang
Traditional robotic devices are often bulky and rigid, making it difficult for them to adapt to the soft and complex shapes of the human body. In stark contrast, soft robots, as a burgeoning class of robotic technology, showcase exceptional...
Metal-polyphenol self-assembled nanodots for NIR-II fluorescence imaging-guided chemodynamic/photodynamic therapy-amplified ferroptosis [0.03%]
用于近红外二区荧光影像引导的化学动力学/光动力学治疗增强铁死亡的金属-多酚自组装纳米点
Yang Zhu,Chengyu Ding,Wenhua Fang et al.
Yang Zhu et al.
The effectiveness of tumor treatment using reactive oxygen species as the primary therapeutic medium is hindered by limitations of tumor microenvironment (TME), such as intrinsic hypoxia in photodynamic therapy (PDT) and overproduction of r...
3D bioprinting of an in vitro hepatoma microenvironment model: Establishment, evaluation, and anticancer drug testing [0.03%]
体外肝癌微环境模型的三维生物打印：建立、评估与抗癌药物测试
Xiaoyuan Wang,Xiaoning Yang,Zixian Liu et al.
Xiaoyuan Wang et al.
Tumor behavior, including its response to treatments, is influenced by interactions between mesenchymal and malignant cells, as well as their spatial arrangement. To study tumor biology and evaluate anticancer drugs, accurate 3D tumor model...
Temperature-sensitive nanogels combined with polyphosphate and cisplatin for the enhancement of tumor artery embolization by coagulation activation [0.03%]
温敏型纳胶结合多聚磷酸和顺铂通过激活凝血作用增强肿瘤动脉栓塞效应
Dingwen Shi,Yanqiao Ren,Yiming Liu et al.
Dingwen Shi et al.
Transcatheter arterial chemoembolization (TACE) is the first-line therapy for hepatocellular carcinoma (HCC). However, the exacerbated hypoxia microenvironment induces tumor relapse and metastasis post-TACE. Here, temperature-sensitive bloc...
Site-specific tethering nanobodies on recombinant adeno-associated virus vectors for retargeted gene therapy [0.03%]
定点递送纳米抗体的重组腺相关病毒载体用于重定位基因治疗
Yuanjie Zhang,Zhiqian Chen,Xiaoyang Wang et al.
Yuanjie Zhang et al.
Recombinant adeno-associated viruses (rAAVs) have been extensively studied for decades as carriers for delivering therapeutic genes. However, designing rAAV vectors with selective tropism for specific cell types and tissues has remained cha...
An acid-activatable fluorouracil prodrug for colorectal cancer synergistic therapy [0.03%]
用于结直肠癌协同治疗的酸可激活型氟尿嘧啶前药
Xiaoqian Ma,Nuo Lin,Ke Hu et al.
Xiaoqian Ma et al.
5-Fluorouracil has demonstrated certain efficiency in patients with colorectal cancer. However, significant side effects of use by injection are common. To address this issue defects, a reengineered 5'-deoxy-5-fluorocytidine (DFCR) based dr...
3D printed O2-generating scaffolds enhance osteoprogenitor- and type H vessel recruitment during bone healing [0.03%]
3D打印的O2生成支架可增强骨愈合过程中骨祖细胞和类型H血管募集
Naboneeta Sarkar,Jingtong Zhao,Nicholas Y Zhang et al.
Naboneeta Sarkar et al.
Oxygen (O2)-delivering tissue substitutes have shown tremendous potential for enhancing tissue regeneration, maturation, and healing. As O2 is both a metabolite and powerful signaling molecule, providing controlled delivery is crucial for o...
Biomechanical and biochemical changes in murine skin during development and aging [0.03%]
小鼠皮肤在发育和衰老过程中的生物力学和生化变化
Anastasiya Martyts,David Sachs,Paul Hiebert et al.
Anastasiya Martyts et al.
Aging leads to biochemical and biomechanical changes in skin, with biological and functional consequences. Despite extensive literature on skin aging, there is a lack of studies which investigate the maturation of the tissue and connect the...
Hollow mesoporous calcium peroxide nanoparticles for drug-free tumor calcicoptosis therapy [0.03%]
空心介孔钙过氧化物纳米颗粒无药瘤内注射诱导肿瘤钙化疗法
Huimin Zhou,Jing Yang,Zongheng Li et al.
Huimin Zhou et al.
Calcium ions (Ca2+) participate in the regulation of cellular apoptosis as a second messenger. Calcium overload, which refers to the abnormal elevation of intracellular Ca2+ concentration, is a factor that can lead to cell death. Here, base...
3D printing calcium phosphate ceramics with high osteoinductivity through pore architecture optimization [0.03%]
通过孔结构优化的高成骨诱导性的钙磷陶瓷的三维打印技术
Yonghao Wu,Puxin Liu,Cong Feng et al.
Yonghao Wu et al.
The osteoinductivity of 3D printed calcium phosphate (CaP) ceramics has a large gap compared with those prepared by conventional foaming methods, and improving the osteoinductivity of 3D printing CaP ceramics is crucial for successful appli...