Separable nanocomposite hydrogel microneedles for intradermal and sustained delivery of antigens to enhance adaptive immune responses [0.03%]
一种可分离的纳米复合水凝胶微针，用于皮内和持续输送抗原以增强适应性免疫反应
Yanting Zheng,Zhiming Li,Shaohua Li et al.
Yanting Zheng et al.
Vaccines play a critical role in combating infectious diseases and cancers, yet improving their efficacy remains challenging. Here, we introduce a separable nanocomposite hydrogel microneedle (NHMN) patch designed for intradermal and sustai...
Zwitterionic nanoparticles from indocyanine green dimerization for imaging-guided cancer phototherapy [0.03%]
基于吲哚青绿二聚体的两性离子纳米粒子用于影像引导光动力/光热联合治疗癌症
Wenbi Feng,Xueluer Mu,Yajie Li et al.
Wenbi Feng et al.
Indocyanine green (ICG), the only near-infrared (NIR) dye approved for clinical use, has received increasing attention as a theranostic agent wherein diagnosis (fluorescence) is combined with therapy (phototherapy), but suffers rapid hepati...
NIR-II light-powered core-shell prodrug nanomotors enhance cancer therapy through synergistic oxidative stress-photothermo modulation [0.03%]
近红外二区光驱动核壳结构前药纳米马达通过协同氧化应激-光热调控增强癌症治疗
Yuwei Gao,Yan Li,Xuesha Yan et al.
Yuwei Gao et al.
Near-infrared-II (NIR-II) photothermal therapy is emerging as a cutting-edge modality for tumor ablation due to its good biosafety, high penetration ability and spatiotemporal controllability. Despite efforts, establishing a link between ce...
Second harmonic generation microscopy, biaxial mechanical tests and fiber dispersion models in human skin biomechanics [0.03%]
人皮肤生物力学的二次谐波发生显微镜、双向机械试验和纤维散射模型
Riccardo Alberini,Andrea Spagnoli,Mohammad Javad Sadeghinia et al.
Riccardo Alberini et al.
Advanced numerical simulations of the mechanical behavior of human skin require thorough calibration of the material's constitutive models based on experimental ex vivo mechanical tests along with images of tissue microstructure for a varie...
Olga Smirnova,Yuri Efremov,Timofey Klyucherev et al.
Olga Smirnova et al.
Extracellular vesicles (EV) are a heterogeneous group of lipid particles excreted by cells. They play an important role in regeneration, development, inflammation, and cancer progression, together with the extracellular matrix (ECM), which ...
An injectable adhesive hydrogel for photothermal ablation and antitumor immune activation against bacteria-associated oral squamous cell carcinoma [0.03%]
一种用于细菌相关口腔鳞状细胞癌光热消融和抗肿瘤免疫激活的可注射粘合水凝胶
Liya Bai,Meng Yang,Jiaxin Wu et al.
Liya Bai et al.
Pathogenic bacteria are closely associated with the occurrence, development and metastasis of oral squamous cell carcinoma (OSCC). Antibacterial therapy has been considered an enhancement strategy to suppress bacteria-associated tumors and ...
A comprehensive review on modeling aspects of infusion-based drug delivery in the brain [0.03%]
脑内输注给药建模方面的综述性文章
Tian Yuan,Wenbo Zhan,Michele Terzano et al.
Tian Yuan et al.
Brain disorders represent an ever-increasing health challenge worldwide. While conventional drug therapies are less effective due to the presence of the blood-brain barrier, infusion-based methods of drug delivery to the brain represent a p...
Chemotactic recruitment of genetically engineered cell membrane-camouflaged metal-organic framework nanoparticles for ischemic osteonecrosis treatment [0.03%]
趋化性募集基因工程细胞膜伪装的金属有机框架纳米粒子治疗缺血性骨坏死
Hongyi Jiang,Weijie Xia,Tian Xia et al.
Hongyi Jiang et al.
Ischemic osteonecrosis, particularly glucocorticoid-induced osteonecrosis of the femoral head (GIONFH), is primarily due to the dysfunction of osteogenesis and angiogenesis. miRNA, as a therapeutic system with immense potential, plays a vit...
Intermittent cyclic stretch of engineered ligaments drives hierarchical collagen fiber maturation in a dose- and organizational-dependent manner [0.03%]
工程化韧带的间歇式周期拉伸以剂量和组织依赖性方式促进胶原纤维层次结构成熟
Leia D Troop,Jennifer L Puetzer
Leia D Troop
Hierarchical collagen fibers are the primary source of strength in tendons and ligaments; however, these fibers largely do not regenerate after injury or with repair, resulting in limited treatment options. We previously developed a static ...
In vitro and in vivo evaluation of osteogenesis and antibacterial activity of MgGa alloys [0.03%]
镁镓合金体外和体内的成骨作用及抗菌性能评估
Ziyue Zhang,Donglei He,Xueying Wang et al.
Ziyue Zhang et al.
MgGa alloys are considered highly potential biodegradable materials, owing to its good mechanical properties and appropriate corrosion resistance. However, it is still far from application due to the lack of biological evaluation. In the pr...