Heparinized self-healing polymer coating with inflammation modulation for blood-contacting biomedical devices [0.03%]
用于血液接触型生物医学设备的肝素化自愈聚合物涂层的抗炎调节作用
Honghong Chen,Zehong Xiang,Tianci Zhang et al.
Honghong Chen et al.
The current techniques for antithrombotic coating on blood-contacting biomedical materials and devices are usually complex and lack practical feasibility with weak coating stability and low heparin immobilization. Here, a heparinized self-h...
Emi Hatano,Nahid Akhter,Risa Anada et al.
Emi Hatano et al.
The cell (plasma) membrane is enriched with numerous receptors, ligands, enzymes, and phospholipids that play important roles in cell-cell and cell-extracellular matrix interactions governing, for instance, tissue development and repair. We...
A three-dimensional valve-on-chip microphysiological system implicates cell cycle progression, cholesterol metabolism and protein homeostasis in early calcific aortic valve disease progression [0.03%]
三维心脏瓣膜生理系统芯片表明细胞周期进程、胆固醇代谢和蛋白质稳态参与早期心脏瓣膜病的发病过程
Ishita Tandon,Alan E Woessner,Laίs A Ferreira et al.
Ishita Tandon et al.
Background: Calcific aortic valve disease (CAVD) is one of the most common forms of valvulopathy, with a 50 % elevated risk of a fatal cardiovascular event, and greater than 15,000 annual deaths in North America alone. Th...
Multifunctional single-component photosensitizers as metal-free ferroptosis inducers for enhanced photodynamic immunotherapy [0.03%]
多功能单组分光敏剂作为无金属铁死亡诱导剂用于增强光动力免疫治疗
Laiping Fang,Qi Meng,Jizhuang Wang et al.
Laiping Fang et al.
Immunotherapy can enhance primary tumor efficacy, restrict distant growth, and combat lung metastasis. Unfortunately, it remains challenging to effectively activate the immune response. Here, tertiary butyl, methoxy, and triphenylamine (TPA...
CD44-hyaluronan mediating endocytosis of iron-platinum alloy nanoparticles induces ferroptotic cell death in mesenchymal-state lung cancer cells with tyrosine kinase inhibitor resistance [0.03%]
CD44-透明质酸介导的铁铂合金纳米颗粒内吞诱导间充质状态酪氨酸激酶抑制剂耐受性肺癌细胞发生铁死亡
Tsunglin Tsai,Shangyin Wu,Yuhsuan Lai et al.
Tsunglin Tsai et al.
While tyrosine kinase inhibitor resistance in cancer is a critical issue in the medical field, it is important for clinical testing as well, since it affects the ultimate outcome of cancer therapy. Yet, no effective solutions have been impl...
Escherichia coli exopolysaccharides disrupt Pseudomonas aeruginosa biofilm and increase its antibiotic susceptibility [0.03%]
芽孢杆菌生物被膜及抗生素敏感性的影响
Chenxiao Wan,Xiaoyan Ju,Dandan Xu et al.
Chenxiao Wan et al.
Pseudomonas aeruginosa (P. aeruginosa) is a major pathogen that causes infectious diseases. It has high tendency to form biofilms, resulting in the failure of traditional antibiotic therapies. Inspired by the phenomenon that co-culture of E...
Collagen-based hydrogels induce hyaline cartilage regeneration by immunomodulation and homeostasis maintenance [0.03%]
基质调节和维持软骨稳态的胶原蛋白水凝胶诱导透明软骨再生
Yongli Gao,Jing Wang,Wenling Dai et al.
Yongli Gao et al.
Type I collagen (Col I) and hyaluronic acid (HA), derived from the extracellular matrix (ECM), have found widespread application in cartilage tissue engineering. Nevertheless, the potential of cell-free collagen-based scaffolds to induce in...
Crizotinib resistance reversal in ALK-positive lung cancer through zeolitic imidazolate framework-based mitochondrial damage [0.03%]
基于分子筛咪唑酸盐框架的线粒体损伤诱导ALK阳性肺癌细胞克服克唑替尼耐药性
Zhouhua Li,Xuehua Ma,Yanqiang Yang et al.
Zhouhua Li et al.
Crizotinib (CRZ), one of anaplastic lymphoma kinase tyrosine kinase inhibitors (ALK-TKIs), has emerged as a frontline treatment for ALK-positive (ALK+) lung adenocarcinoma. However, the overexpression of P-glycoprotein (P-gp, a mitochondria...
Binary fabrication of decellularized lung extracellular matrix hybridgels for in vitro chronic obstructive pulmonary disease modeling [0.03%]
用于体外慢性阻塞性肺疾病建模的脱细胞化肺基质水凝胶的二元制备法
Leigh-Ann M Antczak,Karah N Moore,Taylor E Hendrick et al.
Leigh-Ann M Antczak et al.
Limited treatments and a lack of appropriate animal models have spurred the study of scaffolds to mimic lung disease in vitro. Decellularized human lung and its application in extracellular matrix (ECM) hydrogels has advanced the developmen...
Dissolving magnesium hydroxide implants enhance mainly cancellous bone formation whereas degrading RS66 implants lead to prominent periosteal bone formation in rabbits [0.03%]
镁氢氧化物溶入式种植体主要促进兔松质骨形成而RS66降解式种植体则主要促进骨外膜形成
Elmar Willbold,Katharina Kalla,Carla Janning et al.
Elmar Willbold et al.
Bone fractures often require internal fixation using plates or screws. Normally, these devices are made of permanent metals like titanium providing necessary strength and biocompatibility. However, they can also cause long-term complication...