Time and space modulation of substrate curvature to regulate cell mechanical identity [0.03%]
通过调节基底曲率的时空变化调控细胞机械特性
Stefania Saporito,Valeria Panzetta,Paolo Antonio Netti
Stefania Saporito
Recently, a variety of microenvironmental biophysical stimuli have been proved to play a crucial role in regulating cell functions. Among them, morpho-physical cues, like curvature, are emerging as key regulators of cellular behavior. Chang...
Mitochondria-targeted sonodynamic modulation of neuroinflammation to protect against myocardial ischemia‒reperfusion injury [0.03%]
线粒体靶向声动力调控神经炎症以防治心肌缺血再灌注损伤
Haoyuan Hu,Qian Li,Jiale Wang et al.
Haoyuan Hu et al.
Sympathetic hyperactivation and inflammatory responses are the main causes of myocardial ischemia‒reperfusion (I/R) injury and myocardial I/R-related ventricular arrhythmias (VAs). Previous studies have demonstrated that light-emitting dio...
An engineered cellular carrier delivers miR-138-5p to enhance mitophagy and protect hypoxic-injured neurons via the DNMT3A/Rhebl1 axis [0.03%]
一种工程化细胞载体通过DNMT3A/RHEBL1轴递送miR-138-5p增强线粒体自噬保护缺氧损伤的神经元
Xingjia Zhu,Qianqian Liu,Fengwei Zhu et al.
Xingjia Zhu et al.
Mitophagy influences the progression and prognosis of ischemic stroke (IS). However, whether DNA methylation in the brain is associated with altered mitophagy in hypoxia-injured neurons remains unclear. Here, miR-138-5p was found to be high...
Matrix metalloproteinase-responsive hydrogels with tunable retention for on-demand therapy of inflammatory bowel disease [0.03%]
可调滞留以满足需求的炎性肠病治疗的基质金属蛋白酶响应水凝胶
Xueyong Xie,Yaohui Wang,Bo Deng et al.
Xueyong Xie et al.
Therapeutic options for addressing inflammatory bowel disease (IBD) include the administration of an enema to reduce intestinal inflammation and alleviate associated symptoms. However, uncontrollable retention of enemas in the intestinal tr...
Engineered nanofibrillar collagen with tunable biophysical properties for myogenic, endothelial, and osteogenic cell guidance [0.03%]
一种用于肌源性、内皮和成骨细胞导向的具有可调物理性能的仿生纳米胶原纤维结构
Yong How Tan,Krista M Habing,Jessica L Riesterer et al.
Yong How Tan et al.
A goal of regenerative engineering is the rational design of materials to restore the structure-function relationships that drive reparative programs in damaged tissues. Despite the widespread use of extracellular matrices for engineering t...
Bioinspired oriented calcium phosphate nanocrystal arrays with bactericidal and osteogenic properties [0.03%]
一种具有抗菌和促骨本领的生物启发性定向磷酸钙纳米晶阵列
Lorenzo Degli Esposti,Damiano Squitieri,Camilla Fusacchia et al.
Lorenzo Degli Esposti et al.
The global diffusion of antibiotic resistance poses a severe threat to public health. Addressing antibiotic-resistant infections requires innovative approaches, such as antibacterial nanostructured surfaces (ANSs). These surfaces, featuring...
On-demand bactericidal and self-adaptive antifouling hydrogels for self-healing and lubricant coatings of catheters [0.03%]
用于导尿管自修复和润滑涂层的按需杀菌和自我适应防污水凝胶
Pan Ran,Bo Qiu,Huan Zheng et al.
Pan Ran et al.
Catheter-related infections are one of the most common nosocomial infections with increasing morbidity and mortality, and robust antibacterial or antifouling catheter coatings remain great challenges for long-term implantation. Herein, mult...
Growth factor-loaded ovarian extracellular matrix hydrogels promote in vivo ovarian niche regeneration and enhance fertility in premature ovarian insufficiency preclinical models [0.03%]
负载生长因子的卵巢细胞外基质水凝胶促进早发性卵巢功能不全临床前模型中卵巢生态位的再生并增强其生育能力
Emilio Francés-Herrero,Clara Bueno-Fernandez,Adolfo Rodríguez-Eguren et al.
Emilio Francés-Herrero et al.
Premature ovarian insufficiency (POI) means menopause before 40 years of age affecting about 1 % of women. Approaches based on cell therapy and the paracrine effects of stem cells or bioproducts such as platelet-rich plasma have been propos...
Shape memory cycle conditions impact human bone marrow stromal cell binding to RGD- and YIGSR-conjugated poly (glycerol dodecanedioate) [0.03%]
形状记忆循环条件影响RGD和YIGSR修饰的聚甘油十二二酸酯对人骨髓stromal细胞的结合性能
Harsha Ramaraju,Elisa Garcia-Gomez,Annabel M McAtee et al.
Harsha Ramaraju et al.
Bioresorbable shape memory polymers (SMP) are an emerging class of polymers that can help address several challenges associated with minimally invasive surgery by providing a solution for structural tissue repair. Like most synthetic polyme...
An endothelium membrane mimetic antithrombotic coating enables safer and longer extracorporeal membrane oxygenation application [0.03%]
一种内皮膜仿生抗凝涂层使体外膜肺氧合更安全且可长期应用
Rong Li,Jiefeng Xu,Yin Li et al.
Rong Li et al.
Thrombosis and plasma leakage are two of the most frequent dysfunctions of polypropylene (PP) hollow fiber membrane (PPM) used in extracorporeal membrane oxygenation (ECMO) therapy. In this study, a superhydrophilic endothelial membrane mim...