A Liposomal Nanovaccine Reprograms Post-Ablation Macrophages to Sustain Antitumor Immunity in Hepatocellular Carcinoma [0.03%]
一种肝细胞癌纳米疫苗可重新编程术后巨噬细胞以维持抗肿瘤免疫疗法
Fengkai Qiu,Huilin Hu,Kai Li et al.
Fengkai Qiu et al.
Incomplete radiofrequency ablation (iRFA) of hepatocellular carcinoma frequently results in tumor recurrence driven by residual tumor cells and an immunosuppressive microenvironment dominated by M2 macrophages. Although RFA transiently stim...
Emerging Biomaterials Deliver Heat Shock Protein 90 Inhibitors to Enhance Therapeutic Efficacy in Cancer Therapy [0.03%]
新型生物材料通过递送热休克蛋白90抑制剂提高癌症治疗的疗效
Yujie Wen,Min Li,Xuesheng Tan et al.
Yujie Wen et al.
Innovative biomaterial-based drug delivery systems have shown notable promise in the clinical cancer treatment. However, the therapeutic effect for patients remains highly variable, and new strategies urgently need to be developed. Heat sho...
Morphology-mechanics coupling in intraluminal thrombus from abdominal aortic aneurysm visualized by synchrotron imaging [0.03%]
基于同步辐射成像的腹主动脉瘤腔内血栓微观结构-力学耦合关系研究
Joris Léonet,Mariangela de Masi-Jacquier,Hubert Lepidi et al.
Joris Léonet et al.
Abdominal aortic aneurysm (AAA) rupture is a life-threatening event, yet current rupture risk assessment based on aneurysm size and growth rate fails to fully predict outcomes. Intraluminal thrombus (ILT), present in most AAAs, may influenc...
Modular assembly of human auricular chondrocyte-derived microtissues for ear cartilage tissue engineering [0.03%]
人耳软骨细胞衍生微组织的模块化组装用于耳软骨组织工程
Yu Ting Lau,Hong Cai Li,Wai Yee Valerie Ho et al.
Yu Ting Lau et al.
Existing grafts for reconstructing deformed human auricles, primarily autologous rib cartilage graft and synthetic Medpor implant, have significant drawbacks. Tissue engineering approaches offer hope in developing better human ear grafts bu...
Cationic interfacial engineering of ceria nanotherapeutics enables epithelial barrier penetration and stromal fibrosis inhibition in corneal alkali burns [0.03%]
阳离子界面工程化纳米氧化铈药物用于角膜碱烧伤后上皮屏障穿透及间质纤维化的抑制作用
Tzong-Yun Ger,Chia-Jung Yang,David Hui-Kang Ma et al.
Tzong-Yun Ger et al.
Corneal alkali burns frequently lead to severe pathological manifestations (including oxidative stress and inflammatory response) and dysregulated matrix remodeling-associated stromal fibrosis. Current treatments mainly target inflammation ...
Injectable self-healing oxidized hyaluronic acid hydrogel remodels the healing microenvironment for efficient wound closure [0.03%]
可注射自修复氧化透明质酸水凝胶重塑伤口愈合微环境促进有效闭合
Fengya Jing,Tao Liu,Anbei Chen et al.
Fengya Jing et al.
In clinical wound closure, traditional sutures are cumbersome and prone to causing secondary injury, while existing biological adhesives struggle to balance strong adhesion, high safety, and good adaptability within the complex and variable...
Full-field analysis indicates late reperfusion therapy broadens and mechanically smooths the borderzone during post-infarction inflammation [0.03%]
全视野分析发现，在心梗后炎症期间晚期再灌注治疗可扩大并使边区机械性舒张
Daniel P Pearce,Tianyi Zheng,Paul J Campagnola et al.
Daniel P Pearce et al.
Late reperfusion therapy (LRT; ≥ 3 h post-MI) reduces the risk of ventricular rupture following myocardial infarction (MI), yet the mechanisms behind this protection remain unclear. We hypothesized that LRT alters the biomechanical propert...
Streptavidin Functionalized Hyaluronic Acid Hydrogels for Controlled and Customizable Drug Delivery [0.03%]
用于控制药物释放和定制药物释放的streptavidin功能化透明质酸水凝胶
Emily E Sharp,Lorielle Laforest,Yuqi Zhang et al.
Emily E Sharp et al.
Hyaluronic acid (HA)-based hydrogels have emerged as promising materials for tissue repair given their ability to rapidly gel in situ to precisely fill tissue defects, their mechanical tunability and customizable degradation kinetics, and t...
Bioinspired Hydrogel Remodels the Niche after Spinal Cord Injury for Neural Reconnection by Promoting Angiogenesis and Reducing Inflammation [0.03%]
生物启发水凝胶通过促进血管生成和减少炎症重塑脊髓损伤后的微环境以实现神经重建
Haifei Cao,Yicheng Ding,Xingzhi Liu et al.
Haifei Cao et al.
Spinal cord injury (SCI) disrupts the local microenvironmental niche, resulting in persistent neuroinflammation, vascular dysfunction, and impaired neuronal regeneration, presenting a significant challenge for tissue repair. In this context...
A small-molecule self-assembled nano-prodrug for enhanced therapy of cancer stem cell-enriched pancreatic ductal adenocarcinoma [0.03%]
用于治疗富含癌症干细胞的胰腺导管腺癌的小分子自组装纳米前药
Fu Zhang,Chaorong Wang,Yong Huang et al.
Fu Zhang et al.
Cancer stem cells (CSCs) play a pivotal role in the initiation, metastasis, and recurrence of pancreatic tumors, significantly contributing to drug resistance and reducing the efficacy of traditional chemotherapy. To address these challenge...