Mechanically Adaptive Hydrogels Reprogram Apoptotic Cell Clearance to Prevent Tissue Fibrosis [0.03%]
机械适应性水凝胶重新编程凋亡细胞清除以防止组织纤维化
Lina Huang,Chao Lin,Xiang Cui et al.
Lina Huang et al.
Abnormal mechanical stimulation drives fibrotic scar formation in active wounds by sustaining mechanotransduction, promoting apoptotic cell accumulation and pro-fibrotic amplification that constrain functional regeneration. To address this ...
Decellularized Biomaterials for Tendon-to-Bone Healing: Advances and Translational Challenges [0.03%]
肌腱骨愈合的脱细胞生物材料：进展与转化挑战
Hongfu Jin,Chunsen Zhang,Jiahui Chen et al.
Hongfu Jin et al.
Repair of the tendon-to-bone interface remains a major clinical challenge owing to its complex hierarchical architecture and limited intrinsic regenerative capacity. Decellularized biomaterials have emerged as promising scaffolds for tendon...
A tear film-inspired biomimetic strategy with enhanced lubrication, anchoring, and antioxidative properties for dry eye disease [0.03%]
一种泪膜仿生策略，可改善干眼病的润滑、固定和抗氧化性能
Mengxing Lu,Yongan Lin,Dawei Qi et al.
Mengxing Lu et al.
Dry eye disease (DED) is a multifactorial ocular surface disorder driven by tear film instability, excessive evaporation, frictional damage, oxidative stress, and epithelial injury. Current artificial tears mainly replenish aqueous volume a...
M2 macrophage-based biohybrid system regulates intestinal microbiota homeostasis and immunity for the treatment of inflammatory bowel disease [0.03%]
基于M2型巨噬细胞的生物杂化系统调节肠微生物菌群稳态及免疫以治疗炎症性肠病
Yumei Rong,Wenjie Xiao,Nan Wang et al.
Yumei Rong et al.
The pathogenesis of inflammatory bowel disease (IBD) involves a self-perpetuating cycle driven by oxidative stress, microbial dysbiosis, and immune dysregulation. Restoring intestinal microbiota homeostasis and immune balance is therefore c...
Cell Phenotype Phase Separation in Epithelial-Mesenchymal Transition-Mediated Collective Cell Migration [0.03%]
上皮间质转化介导的集体细胞迁移中的细胞表型相分离现象
Weihao Sun,Rui Xue,Ruiyang Pang et al.
Weihao Sun et al.
Collective cell migration plays a critically regulatory role in both physiological and pathological processes, e.g., embryonic development, wound healing, cancer progression and metastasis. Nevertheless, spatiotemporal progression of epithe...
A biomimetic supramolecular hydrogel enabling sequential dual-agent release reprograms the inflammatory microenvironment for sciatic nerve regeneration [0.03%]
一种仿生超分子水凝胶实现双药剂序贯释放 重新编程炎症微环境促进坐骨神经再生
Ziming Zhu,Huilin Huo,Xiaofei Liu et al.
Ziming Zhu et al.
Peripheral nerve injury (PNI) repair is fundamentally hindered by a dysregulated inflammatory microenvironment and insufficient bioactive components. Conventional hydrogels fail to concurrently integrate dynamic responsiveness, neural biomi...
Meghana Kasturi,Caymen M Novak
Meghana Kasturi
Hypoxia and increased tissue stiffness are well established hallmarks of the lung tumor microenvironment and have each been independently implicated in promoting cancer progression, therapy resistance, and metastatic potential. Despite this...
Accurate control of microspheres by surface acoustic waves for quantitative force characterization and cell mechanics measurement [0.03%]
表面声波对微球的精确控制及其在定量力表征和细胞力学测量中的应用研究
Hengchao Qu,Jialin Shi,Hongyu Wang et al.
Hengchao Qu et al.
The mechanical properties of cells are critical indicators of cellular physiological state and function. However, existing technologies still face challenges in achieving non-contact, force-calibrated, and precisely controlled single-probe ...
Formation and evolution of gyri and sulci in fetal brains: A growth-release model [0.03%]
胎儿大脑回和沟的形成与发育：一种生长释放模型
Zhi-Peng Wang,Lin Tian,Yu Zhao et al.
Zhi-Peng Wang et al.
During human prenatal development, the cerebral cortex undergoes a remarkable morphological transformation characterized by the formation and evolution of gyri and sulci. The biomechanical mechanisms underlying the unique cerebral cortical ...
Precise strategies for targeted elimination of senescent cells to combat aging and age-related diseases [0.03%]
精准靶向清除衰老细胞的策略以对抗衰老和与衰老相关疾病
Yan Chen,Danji Zhu,Wenyi Xu et al.
Yan Chen et al.
Cellular senescence is a cell fate marked by a prolonged and generally irreversible cessation of the cell cycle in reaction to stressors and certain physiological events. Senescent cells accumulate with age and contribute to the pathogenesi...