Engineering a Multilayered 3D Stromal Barrier Model for Quantitative Analysis of T Cell Infiltration and Cytotoxicity [0.03%]
工程化多层三维基质屏障模型以定量分析T细胞浸润和细胞毒性
Rii Morimura,Isana Nada,Yuka Mizue et al.
Rii Morimura et al.
The development of immunocompetent three-dimensional (3D) culture systems is critical for advancing in vitro models that enable precise analysis of immune-tumor interactions. Here, we report a biomaterial-based method for engineering a mult...
Development of oxidized hyaluronic acid Based Hydrogels for Neuronal Tissue Engineering: Effects of Matrix Stiffness on Primary Neurons [0.03%]
基于氧化透明质酸水凝胶的神经组织工程研究：基质刚度对原代神经元的影响
Markus Lorke,Sonja Kuth,Renato Frischknecht et al.
Markus Lorke et al.
Due to the presence of hyaluronic acid (HA) in the human body, specifically the brain, HA-based hydrogels are promising candidates for neural tissue engineering applications. Providing the right mechanical and biological properties is essen...
Local viscoelasticity of denaturing spider silk dope is governed by dynamic hierarchical intermolecular interactions [0.03%]
变性蜘蛛丝浆的局部黏弹性由动态分层次的分子间相互作用支配
Karthik R Peddireddy,Hannah R Johnson,Gregory P Holland et al.
Karthik R Peddireddy et al.
The remarkable mechanical properties of spider silk arise from the hierarchical self-assembly of intrinsically disordered spidroins-proteins that are highly sensitive to environmental conditions and mechanical stress. In vivo, spidroins for...
Qiufang Gong,Long Deng,Jiaxi Ru et al.
Qiufang Gong et al.
Traumatic brain injury (TBI), a leading cause of neurological disability, imposes a critical need for early and precise diagnosis due to its complex pathological heterogeneity, which directly impacts treatment efficacy and patient prognosis...
Dual-mechanism mucoadhesive hydrogel integrating pH-independent barriers and autophagy-driven immunotherapy for the treatment of ulcerative colitis [0.03%]
一种双机制黏膜粘附水凝胶，集成独立于pH值的屏障和自噬驱动免疫疗法治疗溃疡性结肠炎
Jie Wang,Shenyuan Ouyang,Gaolong Lin et al.
Jie Wang et al.
Current therapies for ulcerative colitis (UC) face critical challenges, including systemic toxicity and inadequate mucosal regeneration. Herein, we present a pioneering dual-mechanism therapeutic platform integrating pH-independent acid-tre...
Macrophage membrane-camouflaged dual drug-based biomimetic pH-responsive nanomedicine for synergistic antifungal-antioxidant therapy in oral candidiasis [0.03%]
一种伪装巨噬细胞膜的双药pH响应型仿生纳米药物用于口腔念珠菌病协同抗真菌抗氧化治疗
Kaiwen Bao,Yunfan Li,Yantao Li et al.
Kaiwen Bao et al.
The escalating challenges of antifungal drug resistance, toxicity, and limited therapeutic strategies for oral candidiasis (OC) necessitate innovative treatment approaches. This study developed a pH-responsive baicalein-based nanocarrier by...
Biomimetic hydrogel platform reveals active force transduction from retinal pigment epithelium to photoreceptors [0.03%]
类生发凝胶平台揭示视网膜色素上皮向光感受器的主动力传导机制
Sanna Korpela,Maija Kauppila,Viivi Karema-Jokinen et al.
Sanna Korpela et al.
In the eye, the retinal pigment epithelium (RPE) maintains the functionality and welfare of retinal photoreceptors and forms a tight, interlocked structure with photoreceptor outer segments (POSs). The RPE-retina interaction is difficult to...
Improvement of dentin bonding via adhesive monomers with multiple hydrogen bonding moieties [0.03%]
兼具多重氢键受体与给体基团的粘结单体对牙本质粘结性的影响
Denghao Fu,Jonathan Hardy,Caroline R Szczepanski
Denghao Fu
Despite advancements in bonding techniques, the resin-dentin interface remains the weakest point in dental restorations, susceptible to collagen degradation and methacrylate hydrolysis. One strategy to enhance the resin-dentin interface is ...
A pH-Responsive Polycarbonate Nanoplatform enables Sequential Drug Release for Enhanced Apoptotic Cascade Synergy in Non-Small Cell Lung Cancer Therapy [0.03%]
一种pH响应型聚碳酸酯纳米递药平台用于非小细胞肺癌的凋亡级联协同治疗
Jinghang Li,Hao Liao,Shuangyu Tian et al.
Jinghang Li et al.
Tumor heterogeneity poses formidable challenges to effective cancer therapy, necessitating the implementation of combination regimens to achieve enhanced antitumor efficacy. Optimizing drug administration sequences is pivotal to harnessing ...
An in situ fused adhesive with integrated antibacterial and hemostatic functionalities for urgent respiratory fistula sealing and enhanced wound repair [0.03%]
一种集抗菌和止血功能于一体的原位融合粘合剂，用于紧急呼吸瘘密封和增强伤口修复
Wenjie Zhang,YingYing Yang,Jialing Li et al.
Wenjie Zhang et al.
Respiratory fistulas remain clinically challenging in endoscopic treatment due to the absence of convenient non-compressive sealing materials. Here, we developed an in situ self-fused powder adhesive (PP powder) to address this limitation. ...