Zwitterionic Tissue Expanders Reduce Infection and Fibrosis for Enhanced Biocompatibility [0.03%]
两性离子组织扩张器可减少感染和纤维化以增强生物相容性
Stephanie L Fung,Matthew R Aronson,William R Katowitz et al.
Stephanie L Fung et al.
Current osmotic tissue expanders suffer from protein adsorption, bacterial colonization, and excessive fibrotic encapsulation that compromise device performance. In this study, we synthesized zwitterionic hydrogels using methyl methacrylate...
3D printing in ophthalmology: From basic research to clinical transformation [0.03%]
眼科的三维打印技术：从基础研究到临床转化
Zhuotong Wu,Yong Ma,Liyin Wang et al.
Zhuotong Wu et al.
3D printing is reshaping ophthalmic biomaterials, tissue models, implants, biosensors, and drug-delivery systems, but its clinical value depends on matching each printing strategy to ocular-specific requirements rather than on printing capa...
Targeting the mechanics-glycolysis-histone lactylation axis to rescue bone regeneration under insufficient mechanical stimulation [0.03%]
靶向力学-糖酵解-组蛋白乳酸化轴以拯救机械刺激不足条件下的骨再生
Qiyuan Yang,Yandi Chen,Yumeng Wu et al.
Qiyuan Yang et al.
Mechanical signals are essential for bone homeostasis and regeneration. Reduced mechanical stimulation, such as that occurring during fractures, paralysis, or aging, leads to bone loss and impaired osseous repair. However, effective clinica...
Supramolecular Recognition-Based Hydrogels Incorporating Vascular Endothelial Growth Factor and Hesperadin for Infarcted Myocardial Repair and Angiogenesis [0.03%]
基于超分子识别的含血管内皮生长因子和hesperadin水凝胶的心肌修复及促血管新生作用
Kaiyi Zhu,Qian Yang,Xiang Guo et al.
Kaiyi Zhu et al.
Myocardial infarction (MI) induces pathological remodeling that drives heart failure. Dual-targeted approaches addressing myocardial repair and angiogenesis are crucial for improving post-infarct prognosis. Previous research has demonstrate...
Improved localization to sites of hemorrhage via peptide amphiphile nanofibers containing a factor VII-mimetic epitope [0.03%]
含 VII 因子模拟表位的肽两亲分子纳米纤维改善出血部位定位
Trevor P Stone Jr,Sophia L Maragos,James D Greenwood et al.
Trevor P Stone Jr et al.
Hemorrhage is a leading cause of potentially preventable deaths in pre-hospital settings. Hence, there is a great need to develop a therapeutic that can be administered in the field to slow or stop hemorrhage before definitive treatment can...
Identification of In Vivo Constitutive Parameters of Thoracic Aortic Aneurysms Based on the Unified-Fiber-Distribution Model [0.03%]
基于统一纤维分布模型的胸主动脉瘤在体固有参数识别研究
Xue Liang,Tianyu Wang,Wenbin Mao et al.
Xue Liang et al.
Accurate patient-specific aortic-wall constitutive parameters are essential for biomechanical risk assessment of thoracic aortic aneurysms (TAA), yet their non-invasive determination remains challenging. Here, we proposed an inverse finite ...
Juan J Toscano-Angulo,Juan Mora-Macías,Pablo Blázquez-Carmona et al.
Juan J Toscano-Angulo et al.
Osteoporosis significantly challenges fracture healing, particularly in the regeneration of critical-size bone defects. It remains unclear whether osteoporotic woven bone weakness results from impaired intrinsic quality, reduced formation r...
From collagen denaturation caused by a COL1A2 variant to mineral disorganization and tubular occlusion in primary dentin with dentinogenesis imperfecta [0.03%]
由COL1A2变异引起的胶原变性导致的矿化紊乱和小管阻塞在牙本质发育不全中的作用
Shangaya Touraivane,Margot Charlotte Riou,William Woolley et al.
Shangaya Touraivane et al.
Dentinogenesis Imperfecta (DI) is a rare genetic disorder that disrupts the structure and mechanical integrity of dentin, often through alterations to the collagen matrix. In cases associated with Osteogenesis Imperfecta, DI arises from COL...
Time-dependent deformation of the vagina during gestation under controlled pressure [0.03%]
孕期阴道变形的时空依赖性及受控压力下的变形行为研究
Justin Dubik,Aileen Suarez,David Dillard et al.
Justin Dubik et al.
The vagina undergoes extraordinary structural and biomechanical changes throughout pregnancy to facilitate delivery. To characterize the magnitude and temporal progression of these changes, this experimental study quantified the inflation-i...
Lysosomal disruption elicits immunogenic cell death: A saponin-nanoaluminum adjuvant for enhanced cancer immunotherapy [0.03%]
溶酶体破坏引发免疫原性细胞死亡：一种皂苷-纳米铝佐剂用于增强癌症免疫治疗
Jingsong Lu,Jing Yu,Zhenhu Guo et al.
Jingsong Lu et al.
Inducing lysosomal membrane permeabilization (LMP) represents an alternative therapeutic strategy that bypasses conventional genetic or protein targets and triggers cell death by physically tumor disrupting. Herein, QS-21, an FDA-approved s...