Engineering heterogeneous tissues and organs via multi-material bioprinting: Advances, challenges, and opportunities [0.03%]
基于多材料生物打印的异种组织和器官构建：进展、挑战及机遇
Mohan Wu,Miji Yeo,Irem Deniz Derman et al.
Mohan Wu et al.
Native tissues and organs exhibit intrinsic heterogeneity in their structural, compositional, and functional properties, which poses significant challenges towards the development of effective functional substitutes. Multi-material three-di...
Spatial and longitudinal monitoring of cartilage and intervertebral disc extracellular matrix formation using proteoglycan building blocks and click chemistry: specificity, quantification, and detection upon subcutaneous implantation [0.03%]
基于蛋白聚糖构建模块和点击化学的空间纵向监测软骨及椎间盘基质的形成：特异性、量化与皮下植入后的检测
Yeter Dilek,Jaqueline Lourdes Rios,Caroline O&#x;Riordan et al.
Yeter Dilek et al.
Background/objective: The development of regenerative therapies for osteoarthritis and intervertebral disc degeneration requires non-destructive methods to spatiotemporally monitor extracellular matrix (ECM) synthesis. Th...
Hierarchical structure and multiscale mechanical properties of the gooseneck barnacle (Capitulum Mitella) [0.03%]
鹅颈藤壶(Capitulum mitella)的层次结构及多尺度力学性能
Yung-Ya Chuang,Po-Yu Chen
Yung-Ya Chuang
Stalked barnacles represent an evolutionarily earlier lineage than acorn barnacles. They rely not only on rigid shell plates but also a unique flexible yet protective stalk to withstand powerful wave-induced mechanical forces in intertidal ...
A bioactive intramedullary implant enables accelerated bone regeneration and early load-bearing in distraction osteogenesis [0.03%]
一种生物活性髓内植入物能够加速牵张成骨的骨再生和早期负重
Tomohiro Uno,Tien-Ching Lee,Krish Shah et al.
Tomohiro Uno et al.
Distraction osteogenesis (DO) remains limited by prolonged consolidation and delayed bone union. This study evaluated whether a biodegradable, bone morphogenetic protein-2 (BMP-2)-releasing intramedullary implant (IMI) could enhance bone re...
Microporous annealed particle scaffold integrated with autologous tumor cells for personalized postsurgical tumor therapy [0.03%]
负载自体肿瘤细胞的多孔颗粒支架用于术后个性化肿瘤治疗
Gaizhen Kuang,Wenzhao Li,Feika Bian et al.
Gaizhen Kuang et al.
Biomaterial scaffolds hold great potential for addressing tumor recurrence and tissue defects following surgical tumor resection; however, personalized therapy remains a critical barrier to their clinical translation. To address this issue,...
Quinone-amine sonosensitizer nanoplatform loaded with a GSDMD-activating agent for dual-pathway pyroptosis-augmented sonodynamic immunotherapy against glioblastoma [0.03%]
一种醌胺型声敏剂纳米平台负载Gasdermin D激活剂，通过双重途径增强的声动力免疫治疗针对胶质母细胞瘤中的焦亡反应
Ziyang Liu,Jiamei Zhao,Yuejia Ding et al.
Ziyang Liu et al.
Glioblastoma (GBM) treatment is limited by the blood-brain barrier (BBB), insufficient sonodynamic efficacy, and an immunosuppressive tumor microenvironment. Here, we developed PG@dOMV, a dOMV-coated nanoplatform co-delivering a quinone-ami...
Mechanics, Fracture, and Fragmentation of Thrombi: A Computational Study Review [0.03%]
血栓的力学、断裂和碎裂：一项计算研究综述
Beikang Gu,Kun Jiang,Taotao Wu et al.
Beikang Gu et al.
Thrombosis drives myocardial infarction, acute ischemic stroke and pulmonary embolism, yet more than half of patients undergoing mechanical thrombectomy fail to achieve functional independence, and residual thrombus is detected in up to 91%...
Inhalable Upper Critical Solution Temperature-type Polymer Nanoparticles with Gradient Spatial Protonation and Thermal Expansion Across Physiological Multibarriers [0.03%]
具有空间梯度质子化和生理多屏障温控膨胀效应的可吸入临界溶液温度型聚合物纳米颗粒
Jie Qiao,Jiaxin Zeng,Hongzhao Jiang et al.
Jie Qiao et al.
Inhalable nanodelivery faces a tricky and paradoxical interfacial challenge: penetrating mucus requires nanoparticles to be negatively charged or neutral to avoid electrostatic trapping, whereas targeting and disrupting bacterial biofilms s...
Engineering Spatially Organized Hair Peg-like Structures in Human Skin Constructs Using Keratinocyte-Dermal Papilla Fibroblast Spheroids and Micropatterned Dermal Scaffolds [0.03%]
利用角质形成细胞-毛乳头成纤维细胞球体和微图案真皮支架工程化人类皮肤结构中的空间有序毛囊状结构
Lindsey G Siegfried,Linli Zhou,Jie Wang et al.
Lindsey G Siegfried et al.
Tissue-engineered skin substitutes (TESS) represent a key therapeutic option for extensive cutaneous injuries when autologous grafting is limited; however, current constructs lack skin appendages, particularly hair follicles, resulting in i...
Zinc-enriched Pathological Biominerals in the Human Kidney Encode their Anatomical Microenvironments [0.03%]
人体肾脏病理生物矿中富含锌元素并记录其解剖微环境信息
Sudarshan Srirangapatanam,Benjamin Greenfield,Jorge Mena et al.
Sudarshan Srirangapatanam et al.
The fundamental mechanisms underlying kidney stone formation remain elusive despite extensive research, limiting prevention strategies and contributing to high recurrence rates. Traditionally understood to arise through systemic urine super...