Tumoroid model recreates clinically relevant phenotypes of high grade serous ovarian cancer cells, carcinoma associated fibroblasts, and macrophages [0.03%]
肿瘤样模型重现高级别浆液性卵巢癌细胞、癌相关成纤维细胞和巨噬细胞的临床相关表型
Kathleen M Burkhard,Ayush Semwal,Benjamin K Johnson et al.
Kathleen M Burkhard et al.
Ovarian cancer, the gynecological malignancy with the lowest survival rate, is significantly influenced by the tumor microenvironment. The mesenchymal subtype of high-grade serous carcinoma (HGSC) shows poor outcomes due to high stromal and...
Sequential dual-drug delivery biomimetic hydrogel for temporal orchestration of acute neuroprotection and chronic regeneration in spinal cord injury [0.03%]
一种仿生水凝胶的序贯双药递送系统用于脊髓损伤急性期神经保护与慢性修复的时序化治疗
Junhao Zhao,Hao Zhong,Baoyang Hu et al.
Junhao Zhao et al.
Spinal cord injury (SCI) represents a major public health challenge, leading to persistent neurological deficits and disabilities that impose substantial medical and economic burdens on individuals and society. This study introduces a seque...
In Vivo Wideband MR Elastography for Assessing Age-Related Viscoelasticity Changes of the Human Brain [0.03%]
基于超宽带磁共振弹性成像的人脑黏弹性年龄变化的体内研究
Jakob Schattenfroh,Tom Meyer,Hossein S Aghamiry et al.
Jakob Schattenfroh et al.
Magnetic Resonance Elastography (MRE) noninvasively maps brain biomechanics and is highly sensitive to alterations associated with aging and neurodegenerative disease. Most implementations use a single frequency or a narrow frequency band, ...
Mucin-Inspired Bottlebrush Polymer Hydrogel for Postoperative Adhesion Prevention [0.03%]
一种用于术后粘连预防的仿穆丁瓶刷状聚合物水凝胶
Gengzhi Ren,Rui Xu,Pan Zhang et al.
Gengzhi Ren et al.
Postoperative adhesions pose a significant clinical challenge, contributing to chronic pain, organ dysfunction, increased morbidity, mortality, and substantial healthcare costs. Current adhesion prevention strategies often rely on physical ...
Engineering bioinspired, high-density collagen microgels with tunable intrafibrillar mineralization for accelerated osteogenesis in vitro and bone regeneration in vivo [0.03%]
一种工程类生物高密度胶原微凝胶的研制及其矿化程度的调节促进体外成骨和体内骨再生
Sofia M Vignolo,Daniela M Roth,May A A Fraga et al.
Sofia M Vignolo et al.
The development of biomaterials that mimic native bone remains a major challenge in regenerative medicine. Here, we present a bioinspired platform using high-density collagen hydrogels with tunable mineral content. These engineered microenv...
Dynamic and static strain levels differentially affect the enzymatic degradation of collagen fibres [0.03%]
动态和静态应变水平对胶原纤维酶促降解的不同影响
Amal K Mansoor,Mark C van Turnhout,Keita Ito et al.
Amal K Mansoor et al.
Collagen fibres are essential for the load-bearing capacity of soft biological tissues, ensuring structural integrity and function. The repair process after injury often involves collagen remodelling, including reorganisation, synthesis, an...
Lipid Nanoparticle-Mediated Cd14 siRNA Delivery Ameliorates the Acute Inflammatory Response to Intracortical Microelectrode Implantation [0.03%]
脂质纳米颗粒介导的CD14小干扰RNA递送可缓解皮质内微电极植入后的急性炎症反应
Francine Graham,Diarmuid W Hutchinson,Taylor J Moon et al.
Francine Graham et al.
Intracortical microelectrodes (IMEs) are an integral component of brain computer interfaces (BCIs) designed to study and treat neurological disorders. Unfortunately, IMEs tend to fail prematurely due in part to the macrophage-mediated infla...
An amyloid-based hydrogel with remineralizing and antibacterial properties for interrupting dental caries [0.03%]
一种具有再矿化和抗菌性能的淀粉样蛋白基水凝胶用于中断龋齿的发展
Fan Li,Danyang Lu,Xiaorui Li et al.
Fan Li et al.
Dental caries is a multifactorial and dynamic disease primarily mediated by biofilm formation, resulting in a disruption of plaque microecological homeostasis and an imbalance in demineralization/remineralization of dental hard tissues. The...
Sulfatase-Responsive Phase-Separating Peptide Coacervates Target Stress Granules to Reverse Sorafenib Resistance in Hepatocellular Carcinoma [0.03%]
硫酸盐响应型相分离肽共聚物靶向应激颗粒以逆转肝癌索拉非尼耐药性
Chenhui Wang,Weishu Wang,Yutong Li et al.
Chenhui Wang et al.
Acquired drug resistance in hepatocellular carcinoma (HCC) hinders the clinical therapeutic efficacy of various drugs, but efficient intervention strategies remain scarce. In this study, we reported a coacervate-fusion strategy for inhibiti...
DNA damage-driven cGAS-STING activation via a nuclear-targeted probe enables potent near-infrared theranostics in breast cancer [0.03%]
一种DNA损伤驱动的cGAS-STING活化型近红外诊疗探针用于乳腺癌治疗诊断一体化研究
Renyuan Liu,Yubo Tan,Yuli Jiang et al.
Renyuan Liu et al.
The escalating challenge of chemoresistance in breast cancer treatment severely limits clinical efficacy, necessitating the urgent development of innovative strategies that synergistically enhance tumor cell eradication and remodel the anti...