Corneal stiffness mapping that accounts for anisotropic properties of corneal tissue [0.03%]
各向异性角膜组织特性的角膜刚度映射技术
Yuanwan Lou,Chenyan Wang,Yabo Ye et al.
Yuanwan Lou et al.
This study introduces Stress-Strain Index (ASSI) maps that quantify and visualize corneal stiffness while accounting for anisotropy driven by collagen fibril orientation. Our earlier efforts to produce SSI maps assume isotropy and overlook ...
Direct Insights into Synthesis, Protein Integrity, and Blood Microrheology of Albumin Microbubbles [0.03%]
白蛋白微气泡的合成、蛋白质完整性及血液微流变学的直接观测研究
Tatiana M Estifeeva,Denis A Borozdenko,Arina V Papugaeva et al.
Tatiana M Estifeeva et al.
Albumin microbubbles (MB) were among the first ultrasound (US) contrast agents used clinically. However, they are believed to contain denatured protein motifs, which compromise their stability, hence, limit their diagnostic and therapeutic ...
Fibronectin Composition and Transglutaminase 2 Cross-linking Cooperatively Regulate Ovarian Cancer Cell Adhesion in ECM-Mimetic Constructs [0.03%]
纤维连接蛋白成分和转谷氨酰胺酶2交联协同调节卵巢癌细胞在模拟基底膜中的黏附性
Ning Yang,Ali Abbaspour,James M Considine et al.
Ning Yang et al.
The extracellular matrix (ECM) plays a crucial role in tumor progression. Here, we analyzed collagen I and cellular fibronectin (cFN) in normal omentum and metastatic omentum from high-grade serous ovarian cancer (HGSOC). The levels of both...
An engineering-reinforced hypoxia-preconditioned exosome-integrated hydrogel delays intervertebral disc degeneration via the PPARγ-autophagy axis [0.03%]
工程强化的富氧预处理外泌体-水凝胶通过PPARγ-自噬轴延缓椎间盘退变
Guantong Sun,Mingzhi Liu,Qingyu Yao et al.
Guantong Sun et al.
The local delivery of exosomes (Exo) through hydrogels is considered an effective method for treating intervertebral disc degeneration (IVDD). Based on the limitations of the hypoxic microenvironment in intervertebral disc (IVD), this study...
Formulation, in vitro physico-chemical and biological assessment of calcium pyrophosphate dihydrate cement for bone tissue engineering [0.03%]
焦磷酸钙二水合物骨组织工程用生物陶瓷的制备及其体外理化与生物学性能评估
L Touati,C Leroy,C Damia et al.
L Touati et al.
Calcium pyrophosphate dihydrate (CPPD: Ca2P2O7.2H2O) crystals are known for their inflammatory potential as pathological calcifications in osteoarthritis while several studies showed the promising potential of calcium pyrophosphate-based ma...
In situ fluid-to-solid converting injectable wet adhesive for comminuted fracture repair via water-activated bonding [0.03%]
水激活 bonding 的用于粉碎性骨折修复的原位固化液体金属湿粘合剂
Shijie Shi,Huan Wang,Song Chen et al.
Shijie Shi et al.
Comminuted fractures, characterized by multiple irregular bone fragments, present significant challenges for traditional fixation methods like plates and screws, often resulting in complex surgeries and delayed healing. Injectable hydrogel ...
Ultrasound-activated directional and controllable nitric oxide therapy for vascular calcification repair through the modulation of eNOS/iNOS homeostasis [0.03%]
通过调节eNOS / iNOS稳态进行血管钙化修复的超声激活定向可控一氧化氮疗法
Chunxia Liu,Mengjing Lin,Jing Dai et al.
Chunxia Liu et al.
Vascular calcification (VC) is a critical pathological hallmark of cardiovascular diseases but current therapeutic options remain inadequate. Nitric oxide (NO) homeostasis plays a vital role in endothelial function and phenotypic transforma...
Dual-functional bioinspired nanospray for accelerated wound healing: Visible light-activated bismuth composites [0.03%]
一种双功能仿生纳米喷雾促进伤口快速愈合：可见光激活的铋复合材料
Yingwen Wang,Xuelei Xu,Yubing Jiao et al.
Yingwen Wang et al.
Infectious wound healing has garnered significant attention due to the increasing prevalence of drug-resistant bacteria, with photodynamic therapy (PDT) emerging as a promising non-invasive approach. Among PDT techniques, visible-light-acti...
Hybrid Cell-Membrane-Coated Biomimetic Nanoparticles for Targeted Noninvasive Intervention in Early Diabetic Retinopathy [0.03%]
用于早期糖尿病视网膜病变靶向无创干预的混合细胞膜涂层仿生纳米颗粒
Fan Yang,Lu Zhang,Zhenping Li et al.
Fan Yang et al.
Diabetic retinopathy (DR), a diabetes mellitus-induced ocular complication, demands non-invasive and effective early interventions to halt disease progression. Here, we developed biomimetic hybrid nanoparticles ([RBC-EC]-NPs) by coating fus...
Programmable DNAzyme walkers on gold nanoplatforms: From rational design to bioimaging/biosensing breakthroughs [0.03%]
基于金纳米平台的可编程DNAzyme行走器：从理性设计到生物影像/生物传感突破
Keqing Wang,Wenjing Zhu,Xin Li et al.
Keqing Wang et al.
DNA walkers play a strategic role in precision medicine for applications such as single-cell analysis and tumor microenvironment modulation, yet face bottlenecks in stability, efficiency, and physiological adaptability. A DNA walker primari...