Gastric Ulcers: Biomaterial‑Based Strategies for Tissue Regeneration and Future Perspectives on Environment‑Designed Biomaterials [0.03%]
胃溃疡：基于生物材料的组织再生策略及环境调控型生物材料的未来展望
Caio F C Souza,Inês Vilela de Sousa,Henrique Fernandes-Mendes et al.
Caio F C Souza et al.
Despite significant progress in our understanding of stomach physiology and the identification of key etiological factors, peptic ulcer disease continues to be a prevalent condition with global health implications. Current therapeutic inter...
Mechanical Properties, Microstructure, and Strike Biomechanics of Tubular Fangs in Neotropical Vipers [0.03%]
新热带蝰蛇管状毒牙的力学性能、显微结构和咬合生物力学
Susana Estrada,Juan Camilo Arredondo,Jaime Pereañez et al.
Susana Estrada et al.
Viper fangs represent one of the most mechanically sophisticated biological penetration devices found in nature. Despite extensive interest in their venom-delivery function, a comprehensive characterization of the structure, composition, an...
Golden Vesicular Nanoadjuvant-Loaded Injectable Hydrogel for Locoregional Photothermal-Immunotherapy of Unresectable Glioblastoma [0.03%]
用于不可切除胶质母细胞瘤局部光热免疫治疗的金气穴纳米佐剂载药注射水凝胶
Songsong Zhao,Zhiwei Sun,Jingyi Wang et al.
Songsong Zhao et al.
Glioblastoma (GBM) as the most malicious primary brain tumor is infiltrative and often unresectable, which coupled with a profoundly immunosuppressive tumor microenvironment (TME) lead to a poor prognosis for patients. Here, we developed a ...
Melt Electrowritten Microfiber-Hydrogel Composite Scaffolds with Local Cross-bridging Reinforcements for Aligned Muscle Tissue Engineering [0.03%]
具有局部交联增强的熔融电写入微纤维水凝胶复合基底用于定向肌肉组织工程
Adam Rauff,Ievgenii Liashenko,Charlotte Lippa et al.
Adam Rauff et al.
Effective regeneration of skeletal muscle with highly aligned fiber architecture remains a significant challenge in tissue engineering. Structural alignment of muscle constructs along with mechanical integrity are crucial for effective engi...
Modeling Tenascin-C-rich Metastatic Tumor Niches in Engineered Hydrogel Biomaterials [0.03%]
基于工程化水凝胶生物材料的Tenascin-C丰富的转移性肿瘤生态位构建与模拟
Aakanksha Jha,Elizabeth R Lawlor,Cole A DeForest
Aakanksha Jha
The extracellular matrix (ECM) plays a pivotal role in shaping tumor behavior by providing biochemical and biophysical cues to cancer cells. Traditional 2D culture systems fail to recapitulate this complexity, and in vivo systems do not rea...
Hierarchical Structures in Mammalian Enamel from Synchrotron X-ray Computed Tomography [0.03%]
同步加速器X射线计算机断层扫描揭示的哺乳动物釉质层次结构
Donna Post Guillen,Gabriel Thompson,Zherui Guo et al.
Donna Post Guillen et al.
Many natural and biological materials exhibit intricate hierarchical architectures to effectively manage crack propagation and fracture. This enables them to overcome the critical trade-off between strength and toughness that plagues modern...
Scaffold-assisted assembly of cell-laden microgels to engineer permeable living constructs for vascularized adipose tissue regeneration [0.03%]
支架辅助组装细胞包埋微凝胶构建含血管脂肪组织再生的渗透性活体结构
Zijie Meng,Danxi Li,Yan Liu et al.
Zijie Meng et al.
Integrating acellular scaffolds with cell-laden hydrogels holds great potential for engineering soft tissue constructs with structural integrity and uniform cellular distribution. However, achieving sustained and viable tissue regeneration ...
Non-Invasive Measurements of Tumor Mechanical Forces Using Fiber Bragg Grating Sensors [0.03%]
基于光纤布拉格光栅的肿瘤力学微环境非侵入式测量技术研究进展
Martina Pulcinelli,Constantina Neophytou,Stella Angeli et al.
Martina Pulcinelli et al.
Mechanical forces in solid tumors strongly affect tumor progression, invasion and treatment. Over the years, several approaches have been developed to investigate tumor mechanobiology, however, existing techniques to quantify mechanical for...
Aging modifies microstructure and material properties of mineralized cartilage and subchondral bone in the murine knee [0.03%]
老化改变了小鼠膝关节矿化软骨和松质骨的微观结构和材料属性
Laura Müller,Stéphane Blouin,Edoardo Pedrinazzi et al.
Laura Müller et al.
The osteochondral junction is a specialized region ensuring the biomechanical and biological integration of the unmineralized articular cartilage with the subchondral bone through an intermediate layer of mineralized cartilage. This locatio...
Injectable and Thermosensitive Poly(2-ethyl-2-oxazoline)-poly(L-alanine) Hydrogel with Enhanced Mechanical Performance and Extended In Vivo Persistence [0.03%]
一种机械性能更佳且体内滞留时间延长的可注射热敏型聚（2-乙基-2-恶唑烷酮）-聚（L-丙氨酸）水凝胶
Zixuan Wang,Xin Wang,Zhiyong Chen et al.
Zixuan Wang et al.
Thermosensitive hydrogels derived from thermogelling polymers have garnered growing interest as injectable biomaterials. However, conventional thermosensitive hydrogels often suffer from inadequate mechanical robustness and limited in vivo ...