ECM-Derived Biomimetic Adhesive Patch Regulating the Inflammatory Microenvironment to Accelerate Oral Ulcer Healing [0.03%]
一种加速口腔溃疡愈合的调节炎症微环境的ECM衍生仿生粘附贴片
Qiu-Shuang Cheng,Sheng-Chang Luo,Kai Fan et al.
Qiu-Shuang Cheng et al.
The effective management of oral ulcers is hindered by the constantly moist oral environment and persistently dysregulated inflammatory microenvironment. Inspired by the hierarchical architecture of native mucosa, we engineered a biomimetic...
Bioactive glasses as reactive biomaterials: dissolution-driven structure-function relationships and predictive modelling [0.03%]
生物活性玻璃作为反应性生物材料的作用机制：溶解驱动的结构功能关系及预测模型
Amirhossein Moghanian,Ahmet Akif Kizilkurtlu,Arang Pazhouheshgar et al.
Amirhossein Moghanian et al.
Bioactive glasses (BGs) are reactive biomaterials whose biological effects arise from dissolution: ion exchange, pH evolution, surface-layer formation and calcium phosphate precipitation. Their performance is therefore shaped not by nominal...
Rethinking hemocompatibility standards: a critical appraisal of current regulatory frameworks for Advanced Therapy Medicinal Products (ATMPs) validation [0.03%]
重新思考血液相容性标准：对当前先进治疗药物(ATMPs)验证监管框架的批判性评估
Hachem Bouarroudj,Constant Gillot,Miriam Cnop et al.
Hachem Bouarroudj et al.
Hemocompatibility, defined as the ability of a product to interact safely with blood components, is a critical requirement for therapies intended for intravascular administration. Current evaluation frameworks, primarily based on ISO 10993-...
Architectural and geometric defects govern distinct load-transfer mechanisms in the meniscus [0.03%]
结构和几何缺陷决定半月板中不同的载荷传递机制
Adi Aharonov,Smadar Elinor Sharon,Yana Portnov et al.
Adi Aharonov et al.
Mechanical disruption in fibrous tissues can arise either from geometric defects that introduce structural discontinuities or from architectural alterations that modify internal load-sharing networks. The mechanical distinction between thes...
Deep learning-enabled tissue engineering scaffold classification using cell morphology [0.03%]
基于细胞形态的深度学习载体内植物支架分类
Fatemeh Razaviamri,Clémence Jégard,Amir Rouhollahi et al.
Fatemeh Razaviamri et al.
The physical properties and architecture of biomaterial scaffolds regulate cell morphology and function; however, evaluating these effects is often slow, low-throughput, and destructive, thereby limiting scalable biomaterial design and opti...
In situ swelling of hydrogel microneedles facilitates suprachoroidal space expansion for targeted delivery of TOP-V122 to the posterior segment [0.03%]
原位水凝胶微针肿胀促进超脉络膜空间扩张以实现眼用药物TOP-V122向后段递送
Ahhyun Lee,Sohyun Park,Jaan Strang et al.
Ahhyun Lee et al.
Posterior segment eye diseases are leading causes of vision impairment, yet current treatments such as intravitreal injections require frequent administration and carry risks of complications, including endophthalmitis and retinal detachmen...
Hydrophilic Porphyrin Copolymers Combined with Autophagy Inhibitors Enhance Tumor Photothermal/Photodynamic Therapy [0.03%]
结合自噬抑制剂的亲水性卟啉共聚物可增强肿瘤光热和光动力联合治疗效应
Yadong Liu,Yifan Xue,Hongru Lin et al.
Yadong Liu et al.
Synergistic photodynamic and photothermal therapy (PDT/PTT) holds immense promise for cancer treatment, yet its efficacy is often compromised by limited photosensitizer performance, glutathione (GSH)-mediated ROS quenching, and tumor-protec...
Engineering Multifunctional Catheters with a Nitric Oxide-Releasing Ciprofloxacin Conjugate to Combat Thrombosis and Infection [0.03%]
用于对抗血栓和感染的多功能导管的工程设计，释放一氧化氮的环丙沙星接合物
Myddelton Parker,Sumit Kumar,Isabel Martinez et al.
Myddelton Parker et al.
Indwelling medical devices, such as intravenous and urinary catheters, have significantly enhanced patient care and greatly improved treatment outcomes. Despite rapid advances in medical devices, infection and thrombosis continue to pose ma...
Ultrafast Water-Responsive Shape-adaptive Magnesium-Loaded Silk Fibroin-based Scaffold Modulates Macrophage Glycolytic Reprogramming for Endogenous Cartilage Regeneration [0.03%]
一种超快响应的水载镁负载丝素蛋白支架基形状自适应支架调控巨噬细胞糖酵解重编程促进软骨原位再生
Zhinan Mao,Xuewei Bi,Yu Qin et al.
Zhinan Mao et al.
Shape-adaptive scaffolds have shown promise in regenerating critical-sized irregular articular cartilage defects. However, limitations on the speed and degree of adaptation, mechanical robustness, host integration, and targeted biological f...
In situ synthesis of a zeolitic imidazolate framework coating on a Mg surface for pH-sensitive drug release [0.03%]
原位合成镁表面的沸石咪唑酸盐框架涂层以用于pH值敏感型药物释放
Xia Li,Hongyan Wang,Di Mei et al.
Xia Li et al.
Mg alloys have become a new generation of biodegradable medical materials due to their good biocompatibility. However, their rapid corrosion rate in physiological environments and the mismatch between their degradation rate and tissue recon...