Modeling of protein networks reveals factors affecting stiffness, yield stress, and strain stiffening in silk fibers [0.03%]
蛋白质网络建模揭示了影响丝纤维刚度、屈服应力和应变硬化因素的影响
Noy Cohen,Fuzhong Zhang
Noy Cohen
Thanks to their high stiffness, tensile strength, and toughness, silk fibers generated significant interest and are being considered for many applications. The superior properties of these fibers stem from a unique microstructure, which com...
Fluorescent mapping of osteocyte-driven bone formation at pre-osteocyte and mature osteocyte lacunae [0.03%]
成骨细胞腔和成熟骨细胞腔驱动的骨形成的荧光定位映射研究
Sarah Ford,Kerstin Tiedemann,Rachel Shapiro et al.
Sarah Ford et al.
Bone modeling and remodeling by osteoblasts and osteoclasts has been considered the primary mechanism of bone metabolism; however, osteocyte bone cells resorb their surrounding perilacunar bone matrix. It is unknown whether perilacunar remo...
Liquid Metal-Based Biomaterials and Flexible Devices for Injectable and Implantable Healthcare [0.03%]
用于可注射和植入式医疗保健的液态金属基生物材料与柔性设备
Yuexin Luo,Yajie Yu,Yumo Chen et al.
Yuexin Luo et al.
Injectable and implantable biomaterials and biomedical devices are crucial for disease diagnosis, monitoring, and treatment, enabling minimally invasive procedures, targeted therapies, and real-time monitoring capabilities. Liquid metals (L...
Transient receptor potential vanilloid 4 modulates substrate stiffness mechanosensing and transcellular pore formation in human Schlemm's canal cells [0.03%]
瞬时受体电位香草酸受体4调节人施勒姆管细胞基底膜刚度感知和跨细胞孔形成
Haiyan Li,Cydney Wong,Seyed Mohammad Siadat et al.
Haiyan Li et al.
Pathological changes in the biomechanical environment of Schlemm's canal (SC) inner wall cells, such as substrate stiffening and increased cellular stretch, are associated with ocular hypertension, a key risk factor for the development of g...
3D printing of high-efficiency biomimetic tendon connection structure for biohybrid robots [0.03%]
用于生物杂交机器人的高效仿生肌腱连接结构的3D打印技术研究
Wenze Wu,Shuaikang Tong,Liuhe Li et al.
Wenze Wu et al.
Biohybrid robots actuated by living cells/tissues are promising candidates for biomedical and environmental monitoring applications. However, conventional connection methods between biological materials and mechanical bodies in biohybrid ro...
The crescent cross-section and dichotomous chitin structure make the proboscis of butterflies and moths a hydraulic spring [0.03%]
新月形横截面和二歧性几丁质结构使蝴蝶和蛾的口器成为一个液压弹簧
Taiyo Yoshioka,Tatiana Stepanova,Artis Brasovs et al.
Taiyo Yoshioka et al.
The proboscis of butterflies and moths is made of two C-shaped tubular strands, each with a crescent cross-section. Together, they form a food canal for fluid uptake. Each strand is sealed at the free end and blood is pumped in at the head....
Micropore-forming Photocurable Tissue Adhesive Promotes Cell Infiltration for Wound Healing [0.03%]
微孔光固化组织粘合剂促进细胞浸润以加速伤口愈合研究
Akihiro Nishiguchi,Miho Ohta,Debabrata Palai et al.
Akihiro Nishiguchi et al.
Tissue adhesives suffer from a trade-off relationship between tissue adhesion strength for long-term wound closure and degradation rate for tissue regeneration, which results in the suppression of postoperative wound healing. Here, we repor...
Reactive Oxygen Species-Responsive Sulfated Polysaccharide-Based Nanogels for Ischemic Stroke: A Precision Therapy through Pathological Microenvironment Modulation [0.03%]
基于硫酸多糖的ROS响应性纳米凝胶用于缺血性脑卒中的治疗：一种通过病理微环境调节实现的精准治疗策略
Dingfu Wang,Dan Li,Xiaolin Liu et al.
Dingfu Wang et al.
Thrombolytic therapy for cardiovascular and cerebrovascular diseases is significantly limited by the short half-life, inadequate targeting specificity, and hemorrhagic complications of conventional therapeutic agents. To overcome these chal...
A photodriven nano-extinguisher alleviates acute bacterial infections via Toll-like Receptor 4-regulated immune response [0.03%]
一种光驱动的纳米灭火器通过 toll 样受体 4 规定的免疫反应缓解急性细菌感染
Jie Li,Ji- Yu Che,Hong- Yu Wang et al.
Jie Li et al.
Pattern recognition receptors on immune cells play essential roles in detecting pathogen-associated molecular patterns and initiating downstream immune defense cascades. Toll-like receptor-4, a key member of the PRR family, regulates macrop...
Broad-spectrum Antibacterial Peptidopolysaccharides for Targeted Therapy of a Drug-resistant Bacterial Liver Abscess [0.03%]
治疗耐药细菌性肝脓肿广谱抗菌肽聚糖的靶向疗法
Luofeng Yu,Jingjie Chen,Pandi Peng et al.
Luofeng Yu et al.
Liver abscesses, which are caused primarily by bacteria, represent a significant clinical challenge. Current therapeutic approaches rely heavily on antibiotics, and their efficacy is constrained by the poor drug delivery efficiency and the ...