Modulation of Peptidoglycan Crosslink Network in Escherichia coli Enhances Water-Responsive Actuation [0.03%]
调节大肠杆菌肽聚糖交联网络增强其响应水的驱动效应
Jonathan W Sun,Chengyu Sun,Seungri Kim et al.
Jonathan W Sun et al.
Peptidoglycan (PG), the primary load-bearing component of bacterial cell envelopes, is a bio-derived material whose mechanical and hydration properties are central to microbial viability and their environmental responsiveness. PG has been i...
State-of-the-art and tomorrow's challenges and opportunities in constitutive modeling of soft biological tissues with a focus on arterial, cardiac and brain biomechanics [0.03%]
软生物组织本构模型的现状、挑战和机遇——注重动脉、心脏及脑部的固体力学问题
Stéphane Avril,Alain Goriely,Gerhard A Holzapfel et al.
Stéphane Avril et al.
The aim of this paper is to provide an up-to-date overview of the constitutive modeling of soft biological tissues, both from a simulation and experimental perspective by taking into account different length scales. After providing some ess...
PFSSTKT(PFS)-functionalized Hierarchical Porous ECM Scaffolds Facilitate Articular Cartilage Regeneration through the Recruitment of Endogenous Stem Cells and Chondrogenic Induction [0.03%]
具有PFS功能分层多孔ECM支架通过募集内源性干细胞和软骨分化促进关节软骨再生
Mingxue Chen,Jiang Wu,Hao Wang et al.
Mingxue Chen et al.
Injury to articular cartilage remains a major clinical challenge owing to its limited self-healing capacity. Current cell-based therapies are limited by issues such as dedifferentiation and regulatory hurdles, whereas existing scaffold syst...
Dynamic monitoring of bone homeostasis by dual fluorescent imaging of osteoblast and osteoclast activity [0.03%]
通过双荧光成像技术动态监测成骨细胞和破骨细胞活性以观察骨稳态变化
Kyung Kwan Lee,Chul Soon Park,Hongki Kim et al.
Kyung Kwan Lee et al.
Bone homeostasis is maintained through a dynamic balance between osteoblasts (OBs)-mediated bone formation and osteoclasts (OCs)-driven bone resorption. While numerous probes have been developed to detect either alkaline phosphatase (ALP) o...
Melt electrowriting-enabled hybrid platforms: Toward functional biomimetic scaffolds for cellular interaction and tissue regeneration [0.03%]
熔融电写技术驱动的混合平台：用于细胞相互作用和组织再生的功能仿生支架的研究进展
Yanping Zhang,Fengqiang Zhao,Shiliang Chen et al.
Yanping Zhang et al.
Melt electrowriting (MEW) is a high-resolution additive manufacturing technique that enables the precise deposition of micro- to submicron-scale fibers, allowing the fabrication of highly ordered 3D fibrous scaffolds. Owing to its unique ca...
A dual-functional anti-thrombotic hydrogel coating integrating immunomodulation and surface passivation for vascular implants under inflammatory conditions [0.03%]
一种双功能抗凝水凝胶涂层在血管植入物炎性条件下的免疫调节和表面钝化作用
Yage Hu,Yao Xiong,Tiantian Zheng et al.
Yage Hu et al.
Cardiovascular implantable devices, such as central venous catheters, often induce thrombus formation in clinical applications. Conventional antithrombotic coatings show limited efficacy in high-risk patients with systemic inflammatory cond...
Size-Transformable amphiphilic dendrimer-based drug Nanomicelles for enhanced tumor penetration in cancer chemotherapy [0.03%]
一种尺寸可变的两亲性树状大分子药物纳米胶束及其在癌症化疗中增强肿瘤渗透性的应用
Wang Chen,Xin Li,Chongqin Pan et al.
Wang Chen et al.
Nanotechnology-based drug delivery systems (NDDSs) represent a promising paradigm for cancer therapy. Nonetheless, their clinical translation is substantially impeded by the heterogeneous and physiologically complex tumor microenvironment-p...
Transmucosal delivery of a dendritic cell-targeting intranasal nanovaccine boosts HIV-1 specific mucosal and systemic immune responses [0.03%]
一种针对鼻粘膜树突状细胞的纳米疫苗通过黏膜递送增强HIV-1特异性黏膜和全身免疫反应
Yaotian Chang,Xiaoqian Xin,Tongshuai Wang et al.
Yaotian Chang et al.
The induction of secretory IgA (sIgA) on mucosal surfaces is crucial for developing vaccines that effectively prevent Human immunodeficiency virus type 1 (HIV-1) transmission. However, the mucosal barrier significantly limits antigen absorp...
Flow‑Dependent Traction in High‑ and Low‑Flow Normal Trabecular Meshwork Cells [0.03%]
高流和低流下小梁网细胞的流动依赖性张力
Alireza Karimi,Hasti Golchin,Ansel Stanik et al.
Alireza Karimi et al.
In the conventional aqueous outflow pathway, high‑flow (HF) regions are compliant and low‑flow (LF) regions are stiff and relatively shear‑insensitive. We investigated whether HF‑ and LF‑derived human trabecular meshwork/juxtacanalicul...
Biomechanical adaptation of the thoracic aorta and its perivascular adipose tissue precedes hypertension development in Dahl Salt-Sensitive rats on high-fat diet [0.03%]
高脂饮食Dahl盐敏感性大鼠主动脉及其血管外脂肪组织的生物力学适应先于高血压发生
Dillon McClintock,Maxwell Hakun,Sydney Bush et al.
Dillon McClintock et al.
This study aimed to quantify sex-dependent biomechanical adaptation mechanisms occurring at or just before significant blood pressure increases in high-fat diet (HFD)-fed Dahl Salt Sensitive (Dahl-SS) rats. The early adaptation stages were ...