Synchrotron tomography-based inversion pipeline for estimating elastic properties for rat vertebral endplate finite element models [0.03%]
基于同步辐射断层扫描的反演流程用于建立大鼠椎间盘终板有限元模型弹性参数属性分布图
Jishizhan Chen,Alissa Parmenter,Aikta Sharma et al.
Jishizhan Chen et al.
Lower back pain is linked to vertebral biomechanics, with vertebral endplates (VEPs) playing a key role. Finite element modelling (FEM) is a powerful tool for studying VEP biomechanics but relies on accurate material property inputs, which ...
Macroporous-channel hollow microneedles enable vacuum-free interstitial fluid sampling and on-patch sensing [0.03%]
具有宏孔通道的中空微针可实现无真空间质液取样和片上检测
Yang Yu,Suisui Liu,Zhenlong Meng et al.
Yang Yu et al.
Microneedle (MN) devices that sample skin interstitial fluid (ISF) without an external vacuum offer strong point-of-care potential, but are often limited by insufficient extraction flux and fabrication complexity. Here, we present macroporo...
Phagocyte-Inspired Supramolecular Self-Assembly Design of Abiotic Cell-Mimics for Pathogen Recognition and Eradication [0.03%]
灵感来源于吞噬细胞的超分子自组装亚稳态仿生细胞用于病原体识别及消除
Shafaq Sahar,Yanni Ge,Sisi Yang et al.
Shafaq Sahar et al.
Pathogens are rapidly evolving resistance against both antibiotics and the human immune system. Artificial cells provide an attractive strategy to engineer cell-like systems from simple abiotic materials, offering tunable properties and fac...
Preparation of nanofibrous membrane-covered saccule gastric tubes and their treatment of radiation esophagitis [0.03%]
纳米纤维膜覆盖球囊食管支架的制备及其对放射性食管炎的治疗研究
Shutao Ma,Li Weng,Xiang Yin et al.
Shutao Ma et al.
Radiation esophagitis (RE) is a frequent acute complication in patients receiving radiotherapy, yet effective local treatment remain unavailable due to the anatomical constraints of the esophagus. Severe cases often require gastric tube pla...
Optimizing strength-ductility, biotribological, angiogenic, and antibacterial properties of hot-rolled and hot-extruded Zn-4Ag-0.4Sr alloys for biodegradable orthopedic fixation [0.03%]
优化可降解医用锌合金力学性能、生物 TRBOV 以及新生血管生成和抗菌性的研究
Runqi Zhou,Zupo Yu,Yuxin Zhang et al.
Runqi Zhou et al.
Biodegradable zinc (Zn) alloys are promising candidates for bone implants due to their suitable degradation rate and inherent bioactivity. However, current Zn alloys require enhancement of their mechanical properties and biological function...
Biomimetic zwitterionic micelles for efficient mucus penetration and pulmonary targeting in acute lung injury [0.03%]
仿生两性离子型胶束促进有效穿透黏液屏障并实现急性肺损伤治疗的肺部靶向给药
Xiangrong Dai,Yi Liao,Rong Chen et al.
Xiangrong Dai et al.
Nebulized inhalation represents an attractive approach for pulmonary drug delivery due to its non-invasiveness and direct lung targeting capability. However, the effectiveness of conventional inhaled formulations is limited by their inabili...
Initiator-particle synergy enables microrough, osteoconductive polymethyl methacrylate bone cement [0.03%]
改良型聚甲基丙烯酸甲酯骨水泥的研制及生物相容性评价
Juri Saruta,Yoshihiko Sugita,Hiroaki Kitajima et al.
Juri Saruta et al.
Conventional polymethyl methacrylate (PMMA) bone cement formulated with benzoyl peroxide (BPO) initiator is biotolerant, cytotoxic, and incapable of true osseointegration. Here, we introduce a transformative surface-engineering strategy tha...
Multifunctional, modular tissue-engineered patch with ECM and synthetic adhesive for sutureless gastrointestinal defect repair [0.03%]
一种用于无创胃肠缺陷修复的多功能模块化组织工程补片（含ECM和合成胶水）
Linqiang Wu,Qi He,Hao Zheng et al.
Linqiang Wu et al.
Gastrointestinal wall defects (e.g., perforations and leaks) present significant clinical challenges due to high rates of leakage, infection, and postoperative tissue adhesions. Current synthetic patches lack biocompatibility, leading to ch...
Structure-functionality relationship of collagen-fibrin interpenetrating hydrogels for engineered tumor-stroma models [0.03%]
胶原-纤维素互穿水凝胶的结构功能关系在工程肿瘤微环境模型中的应用研究
Sae Rome Choi,Seamus M Mellican,Tyler J Roberts et al.
Sae Rome Choi et al.
Collagen and fibrin are two major extracellular matrix (ECM) proteins involved in tumorigenesis. During cancer progression, collagen and fibrin undergo sequential and concurrent polymerization and degradation, altering ECM structure and fun...
Scanning Laser Cavitation Rheology for mesoscopic mapping of shear moduli of soft materials at high strain rates [0.03%]
基于扫描激光空化流变学的软材料高应变率剪切模量介观表征方法研究
Rahul Sreedasyam,Ethan C Vu,Shreya Thota et al.
Rahul Sreedasyam et al.
Mechanical characterization of soft biomaterials is essential for understanding biological function, injury response, and the design of engineered tissues. Conventional techniques such as parallel-plate rheometry are restricted to bulk meas...