Lung tissue viscoelasticity is preserved with bleomycin-induced fibrosis in mice [0.03%]
博来霉素诱导的小鼠肺纤维化过程中肺组织粘弹性能的保持
Leilani R Astrab,Riley T Hannan,Mackenzie L Skelton et al.
Leilani R Astrab et al.
In pulmonary fibrosis, excessive scar tissue accumulates in the alveolar interstitial space, impairing gas exchange and compromising lung function. This fibrotic remodeling results in tissue stiffening, but more complex lung mechanical prop...
Prostate specific membrane antigen-targeted multimodal imaging nanobubbles with ultrasound irradiation inhibit prostate cancer growth via autophagy activation [0.03%]
一种靶向前列腺特异性膜抗原的多功能纳米气泡在超声照射下通过诱导自噬抑制前列腺癌生长
Yi Ling,Xunhu Dong,Jun Zhang et al.
Yi Ling et al.
Ultrasound-targeted nanobubble destruction (UTND) is a promising noninvasive strategy for cancer treatment. However, off-target effects significantly influence UTND-mediated therapeutic efficacy and compromise accurate evaluation of tumors....
Optical Asymmetric Transmission Design with Mechanical Robustness in the Shell of Polinices albumen [0.03%]
一种具有螺相思贝卵素壳机械鲁棒性的光学非对称传输设计
Linzhi Liu,Feng Duan,Ercai Pan et al.
Linzhi Liu et al.
Asymmetric transmission (AT) is crucial for optical devices like isolators and circulators. A key, yet unmet, challenge is integrating this functionality into sturdy, bulk materials that can withstand harsh operating conditions. Here, we re...
A hierarchical assembly strategy for heterogeneous hydrogel constructs from magnetized liquid droplets [0.03%]
基于磁化的液滴组装异质水凝胶结构的策略
Jialong Chen,Zhuohang Du,Yifan Zhang et al.
Jialong Chen et al.
Conventional magnetic assembly strategies for hydrogel constructs face fundamental limitations in achieving multiscale structure construction due to transient magnetic response and lack of magnetic domain programming. We present a hierarchi...
Regional mechanical and microstructural variations in ascending thoracic aortic aneurysms influenced by tricuspid and bicuspid aortic valves [0.03%]
主动脉瓣三叶式或二叶式异常的升主动脉瘤的区域机械和微观结构差异
Omid Ghorbani,Robert Matongo Persson,Mohammad Javad Sadeghinia et al.
Omid Ghorbani et al.
Ascending thoracic aortic aneurysms (ATAAs) exhibit regional biomechanical heterogeneity linked to microstructural changes and comorbidities. This study investigated microstructure and mechanical property variations across six regions of th...
Amal Shabazz,Julia Fitlin,Henry Orozco-Contreras et al.
Amal Shabazz et al.
The repair of soft tissue defects remains a leading clinical challenge for patients with active lifestyles, unintentional falls and injuries, cancer, and age-related diseases. Tissue engineering and 3D printing have been developed over the ...
Design and tissue engineering applications of microporous annealed particle (MAP) scaffolds [0.03%]
微孔烧结颗粒(MAP)支架的设计及组织工程应用
Oluwaseyi Shofolawe-Bakare,Nic D Leipzig
Oluwaseyi Shofolawe-Bakare
Microporous annealed particle (MAP) scaffolds are emerging as a facile, yet sophisticated biomaterial platform with tremendous potential for tissue regenerative applications. These scaffolds are fabricated in situ through interparticle cros...
Preserving Tissue Integrity Under the Beam: High-Energy, Low-Dose Synchrotron CT for in situ Imaging of Bovine Intervertebral Discs [0.03%]
射线下的组织完整性保护：高能低剂量同步加速器CT在牛椎间盘原位成像中的应用
C M Disney,R Lees,A W Parker et al.
C M Disney et al.
In situ tomography enables non-destructive, time-lapse imaging of biological tissues under load, offering insights into structural and mechanical changes. However, repeated scans can expose samples to high radiation doses, potentially alter...
Therapeutic effects of mesenchymal stem cells and their secretomes (extracellular vesicles) with bone-implant scaffolds for bone regeneration: A systematic review and network meta-analysis of preclinical studies [0.03%]
间充质干细胞及其分泌组（细胞外囊泡）与骨-植入支架结合促进骨再生的治疗效果：一项系统综述和预临床研究的网络meta分析
Zuyan Lu,Hongyu Chen,Hanwen Chang et al.
Zuyan Lu et al.
Tissue-engineering strategies combining mesenchymal stem cells (MSCs) or extracellular vesicles (EVs) with bone-regenerative scaffolds may improve healing of critical-size bone defects, yet their comparative efficacy remains unclear. We sys...
Microstructure-dependent transport properties in blood clots: Roles of fiber volume fraction and orientation on permeability and diffusivity [0.03%]
血凝块中的微观结构依赖性传输性质：纤维体积分数和取向对渗透性和扩散系数的影响
Xiran Cao,Tingting Zhang,Qiang Yi et al.
Xiran Cao et al.
Fibrin networks serve as the fundamental structural framework of blood clots. The microstructural features of the networks govern the fluid and mass transport processes within blood clots, which are critical to thrombolytic therapy efficacy...