Cascade-targeting oxygen-self-supplying nano-photosensitizer for enhanced photodynamic immunotherapy of triple-negative breast cancer [0.03%]
用于三阴性乳腺癌光动力免疫治疗的级联靶向供氧纳米光敏剂
Kui Wang,Fengling Wang,Mengjun Yu et al.
Kui Wang et al.
The efficacy of immunogenic photodynamic therapy (PDT) is critically limited by the inadequate tumor accumulation of photosensitizers and the resultant hypoxia in the tumor microenvironment. To address these challenges, we report a multifun...
Multifunctional bioactive peptide-laden and adhesion-switchable dual-crosslinked hydrogel for accelerated healing of infected deep burn wounds [0.03%]
一种多功能生物活性肽负载及可转换粘附性的双交联水凝胶促进感染的深二度烧伤创面加速愈合
Kehan Du,Liya Qi,Haiyan Ren et al.
Kehan Du et al.
Infected deep burn wounds represent a severe clinical challenge due to microbial invasion, persistent inflammation, impaired tissue regeneration, and subsequent scar formation. To address these issues, we developed stimuli-responsive and on...
In vivo self-assembled DNA vaccine elicits efficient immune protection against viral myocarditis by targeting draining lymph nodes [0.03%]
靶向引流淋巴结的体内自组装DNA疫苗可有效预防病毒性心肌炎
Tong Wang,Ke Lin,Yihui Ge et al.
Tong Wang et al.
In this study, we engineered two recombinant fusion proteins by conjugating the streptococcal albumin-binding domain (ABD) to either the N-terminus (AP) or C-terminus (PA) of protamine (P). These proteins spontaneously assembled with the CV...
Gallium-doped mesoporous bioactive glass nanoparticles for antibacterial and immunomodulatory effects in vital pulp therapy [0.03%]
用于活髓治疗的掺杂镓介孔生物活性玻璃纳米颗粒的抗菌和免疫调节作用
Yixing Pi,Zitian Liang,Xin Liu et al.
Yixing Pi et al.
Vital pulp therapy (VPT) is crucial for the self-repair and long-term retention of teeth with pulpitis. Here, we aimed to develop gallium-doped mesoporous bioactive glass nanoparticles (Ga-MBGNs) as a multifunctional pulp capping material f...
Biodegradable Zn-Mg-Ca-Sr alloy intramedullary nails promote vascularized bone regeneration and suppress osteoclastogenesis for osteoporotic fracture repair [0.03%]
可降解的Zn-Mg-Ca-Sr合金髓内钉促进血管化骨再生并抑制破骨细胞生成以修复骨质疏松性骨折
Haotian Qin,Zhenhai Xie,Chen Zhang et al.
Haotian Qin et al.
Osteoporotic fractures are commonly associated with impaired bone regeneration and insufficient mechanical stability, posing major challenges for load-bearing internal fixation. Biodegradable metallic implants that combine mechanical suppor...
Biomaterials for endometriosis treatment: Design, advances, and prospects [0.03%]
用于子宫内膜异位症治疗的生物材料：设计、进展和前景
Yang Liu,Li-Nan Tian,Zhao-Ya Wu et al.
Yang Liu et al.
Endometriosis is a chronic gynecological disease characterized by the presence of ectopic endometrium. Achieving effective therapeutic outcomes for endometriosis has always been a significant clinical hurdle because of the high recurrence r...
The effects of volume exclusion and viscosity on collagen fiber nucleation and network morphology [0.03%]
体积排除和粘度对胶原纤维成核和网络形态的影响
Iris G Mercer,Mindle S Paneth,Mathieu Lecarpentier et al.
Iris G Mercer et al.
Protein behavior, including protein-protein association and self-assembly, differs in dilute buffers compared to in the crowded environments that are typical in vivo. We performed a comprehensive study of the impacts of crowding on collagen...
Micropatterning transcriptionally and phenotypically reprograms endothelial cells [0.03%]
微图案重编程内皮细胞的转录和表型
Paula Josic Dominovic,Meghan E Fallon,Jiaqing Pang et al.
Paula Josic Dominovic et al.
Vascular occlusions are a major cause of cardiovascular disease and require interventions including graft bypass surgery; yet, the development of synthetic vascular grafts remains a challenge due to the inability of synthetic biomaterials t...
Polypyrrole nanozymes with cell-free DNA scavenging and ferroptosis inhibition capabilities for the treatment of acetaminophen-induced acute liver injury [0.03%]
具有无细胞DNA清除和铁死亡抑制能力的聚吡咯纳米酶用于治疗对乙酰氨基酚诱导的急性肝损伤
Yu Liu,Ziwen Xiao,Yu Zhang et al.
Yu Liu et al.
Acute liver failure (ALF) can result from the progressive development of acute liver injury triggered by acetaminophen (APAP) overdose. The core mechanisms involve an imbalance in the antioxidant system and upregulation of the inflammatory ...
Biopreservation of a tissue engineered nigrostriatal pathway for tract reconstruction in Parkinson's disease [0.03%]
帕金森病纹状体神经通路组织工程的生物保存法
Dimple Chouhan,Kevin D Browne,Wisberty J Gordián Vélez et al.
Dimple Chouhan et al.
The typical motor symptoms of Parkinson's disease (PD) are caused by selective loss of dopaminergic neurons in the substantia nigra (SN). Although conventional pharmacotherapies can temporarily alleviate symptoms, no approved therapies exis...