SELF-ASSEMBLED PEPTIDE RADA16 HYDROGEL PROMOTES EPITHELIALIZATION OF WOUNDS BY A LAMININ-332-DEPENDENT SCAVENGING MECHANISM [0.03%]
自组装肽RADA16凝胶通过层粘连蛋白-332依赖性清除机制促进伤口上皮化
Chloé Laigle,Marie Buffier,Emélie Clémens et al.
Chloé Laigle et al.
Re-epithelialization describes the resurfacing of a skin wound with new epidermis as the first step in restoring its integrity and barrier function. In wounds, re-epithelialization progresses from the surrounding wound edges towards the cen...
Microenvironment-Modulating Hyaluronic Acid-Tannic Acid Hydrogel for Peripheral Nerve Injury Repair [0.03%]
基于透明质酸-单宁酸的微环境调控型水凝胶促进周围神经损伤修复
Yao Liu,Kai Liu,Yu Yan et al.
Yao Liu et al.
Peripheral nerve injury typically results in the loss of nervous tissues and motor and sensory functions, leading to serious clinical complications. Excessive oxidative stress and inflammations in the damaged area can severely inhibit nerve...
A multiscale finite element model of fluid-microstructure interactions in human intervertebral disc compression [0.03%]
人椎间盘压缩过程中流-细观结构相互作用的多尺度有限元模型
Ugo Cachot,Karim Kandil,Fahmi Zaïri et al.
Ugo Cachot et al.
The human intervertebral disc (IVD) is a complex, anisotropic structure composed of the nucleus pulposus (NP), annulus fibrosus (AF), and cartilaginous endplates (CEPs), which together enable the spine to bear loads and accommodate multi-di...
Glycosylation-enabled Chemoselective Growth Factor Engineering for Biomaterial Functionalization [0.03%]
糖基化驱动的选择性生长因子工程用于生物材料功能化
Yunhui Xing,Qingyang Li,Ellen L Otto et al.
Yunhui Xing et al.
In native tissue environments, growth factors (GFs) are often physically associated with the extracellular matrix (ECM) framework. Despite the enormous potential of chemoselective click chemistry for biomaterial functionalization to recapit...
Biomineralized PCAL Microspheres Trigger Synergistic Calcicoptosis-Ferroptosis for Enhanced Non-Small Cell Lung Cancer Therapy [0.03%]
仿生矿化PCAL微球触发协同焦亡-铁死亡用于增强非小细胞肺癌治疗
Lingxiao Yang,Kaiyue Wang,Jia Dong et al.
Lingxiao Yang et al.
Non-small cell lung cancer (NSCLC) is characterized by significant tumor heterogeneity and the development of drug resistance, which greatly limit the efficacy of conventional targeted therapies. Emerging evidence has increasingly highlight...
Biomechanical characterization of the human pia-arachnoid complex using bulge inflation testing and the virtual fields method [0.03%]
人脑室内膜-蛛网膜复合体的力学性能研究
Paulien Vandemaele,Heleen Fehervary,Lauranne Maes et al.
Paulien Vandemaele et al.
The cranial meninges are crucial structures in protecting the brain against injury. Hence, a biofidelic mechanical representation of these tissues is essential for accurate computational predictions of stress and strain in the brain during ...
Fabrication of granular decellularized extracellular matrix hydrogels for wound repair [0.03%]
用于伤口修复的颗粒状脱细胞基质水凝胶的制备
Kun Zhang,Noel Richard Prakash,Jordan W Davern et al.
Kun Zhang et al.
Biomaterials derived from decellularized extracellular matrix (dECM) contain a complex mixture of proteins, proteoglycans, and signaling molecules that mimic the native tissue microenvironment and provide important cues for regulating cell ...
Spatio-temporal characterization of compositional and cellular properties in the murine fracture callus [0.03%]
小鼠骨折愈合组织中组成和细胞属性的时空特征描述
Tobias M Ballhause,Ana Ocokoljic,Jan Sevecke et al.
Tobias M Ballhause et al.
Advances in the understanding of the physiological process of bone healing and its impairment (i.e., nonunion) require appropriate models and precise standardization. The femoral osteotomy and external fixation mouse model meets these requi...
Rahul Franklin,Eshan Ganju,Brock A Harpur et al.
Rahul Franklin et al.
Honeycomb is an engineering and architectural marvel used by bees to store food and raise brood. It is constantly being added to or subtracted from by workers in the colony. The size and shape of comb can vary dramatically based on need, an...
Nanomaterials for the treatment and monitoring of obesity: Targeting adipose tissue macrophages [0.03%]
用于肥胖治疗和监测的纳米材料：靶向脂肪组织巨噬细胞
Yuting Tang,Ouzile Chen,Bowen Dong et al.
Yuting Tang et al.
Obesity represents a growing global health crisis, closely associated with chronic low-grade inflammation driven by the recruitment and polarization of adipose tissue macrophages (ATMs). Targeting ATMs to suppress adipose inflammation has e...