Spatially controlling cardiac fibroblast-to-myofibroblast transition using Young's modulus patterned GelMA hydrogels [0.03%]
基于杨氏模量的空间编码明胶甲基丙烯酸酯水凝胶控制心脏纤维细胞转分化为肌成纤维细胞
Harrison Porritt,Alexander Dixon,Anaïs Chalard et al.
Harrison Porritt et al.
The spatial organisation of mechanical cues is increasingly recognised as a key regulator of tissue development and disease, yet in vitro systems capable of replicating such environments remain limited. Fibroblast migration and the fibrobla...
Multifunctional pH-responsive nanocarrier for targeted azithromycin delivery and immune modulation in bacterial sepsis [0.03%]
用于细菌性脓毒症红霉素靶向递送和免疫调控的多功能pH响应型纳米载体
Siran Wang,Lu Yuan,Chang Gao et al.
Siran Wang et al.
Antibiotic resistance, bacterial biofilms, and resulting dysregulated immune responses pose major challenges in the management of bacterial infections, often leading to severe complications such as sepsis. This study introduces a multifunct...
Bioorthogonal and synthetic biology-engineered bacterial outer membrane vesicles for enhanced photo-immunotherapy [0.03%]
用于增强光免疫疗法的生物正交和合成生物学工程化细菌外膜囊泡
Guannan Liu,Zhengyue Fei,Xinyue Tao et al.
Guannan Liu et al.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer immunotherapy, yet their clinical translation is hindered by limited drug-loading capacity, suboptimal tumor accumulation, and rapid clearance, which co...
Chemical modifications of RNA influence the micellar assembly stability and intracellular distribution of polycation/RNA complexes [0.03%]
RNA化学修饰影响多阳离子/RNA复合物的胶束缔合稳定性及其细胞内分布
Fengyi Wang,Yuqi Tong,Liejing Lu et al.
Fengyi Wang et al.
RNA molecules play a crucial role in regulating genetic information within cells and have increasingly emerged as a promising class of therapeutic agents for a wide range of diseases. The delivery of RNA to intracellular targets remains a p...
Tear Glucose-Responsive and Photo-activated Antibacterial Hydrogel Bandage with Bio-heterojunction for the Treatment of Drug-Resistant Bacterial Corneal Infection [0.03%]
用于治疗耐药细菌性角膜感染的基于生物异质结的可响应眼泪葡萄糖和光激活的抗菌水凝胶绷带
Liangyu Zhou,Shuowen Zhou,Ying Chen et al.
Liangyu Zhou et al.
Bacterial keratitis (BK) contributes to more than half of the cases of corneal infection, which is caused by bacterial infection on cornea. BK can lead to severe vision loss or even blindness if appropriate treatment is not provided in a ti...
Stent-Graft Compliance Modulates Regional Mechanical and Structural Remodeling of the Aorta [0.03%]
血管支架顺应性可调节主动脉局部机械和结构重塑
Ramin Shahbad,Sivapriya Kuniyil,Jason MacTaggart et al.
Ramin Shahbad et al.
Endovascular aortic stent-grafts often introduce a compliance mismatch with the native aorta, potentially leading to adverse remodeling. This study assessed how stent-graft compliance affects structural, mechanical, and morphometric adaptat...
Bone regeneration, tendon fiber formation, and angiogenesis are enhanced by the multifaceted effects of biodegradable octacalcium phosphate and gelatin scaffold materials [0.03%]
可生物降解八钙磷酸盐和明胶支架材料通过多效性作用促进骨再生、肌腱纤维形成和血管生成
Osamu Suzuki,Yu Mori,Ryo Hamai et al.
Osamu Suzuki et al.
The concept is highly attractive from the perspective of biomaterials science and tissue engineering: if a single material can act diversely on several cell types, promoting the regeneration of their respective tissues. The studies have sho...
Conformation-driven mechanical duality: Viscoelastic and poroelastic switching in protein hydrogels [0.03%]
构象驱动的机械二元性：蛋白质水凝胶中的粘弹性与孔隙弹性转换现象
Mattan Ze&#x;ev Becker,Maya Georgia Pelah,Ofek Avrahami et al.
Mattan Ze&#x;ev Becker et al.
Bovine serum albumin (BSA) hydrogels reveal a fundamental mechanical duality in protein-based biomaterials. Using chemically crosslinked BSA networks as a model system, we show that the same hydrogel can dissipate stress through two distinc...
Bio-lubrication in insect joints: A lesson for designing a low-friction micro-bearing [0.03%]
昆虫关节的生物润滑作用——设计低摩擦微轴承的启示
Carmine Putignano,Konstantin Nadein,Julian Thomas et al.
Carmine Putignano et al.
An insect joint operates, from a mechanical perspective, as a sub-millimetric bearing: remarkable tribological properties are here ensured thanks to relatively soft, elongated-cylindrical filaments secreted through the pores present in the ...
Enhanced Immunotherapy Efficacy through Molecularly Imprinted Nanoparticles Co-Targeting Cluster of Differentiation-73 and Programmed Death-Ligand 1 [0.03%]
通过分子印迹纳米颗粒联合靶向分化簇73和程序性死亡配体1增强免疫治疗效力
Yanjie Han,Haohao Song,Zikuan Gu et al.
Yanjie Han et al.
Immune checkpoint blockade (ICB) therapy has emerged as an appealing cancer treatment strategy, yet its efficacy is frequently limited by insufficient T cell infiltration and an immunosuppressive tumor microenvironment (TME). To overcome th...