Bovine serum albumin-stabilized nano-delivery system potentiates targeted anti-angiogenic therapy and synergistic photo-immunotherapy to restrict lung cancer metastasis [0.03%]
Nannan Fu,Zhixiong Zhan,Zhan Li et al.
Nannan Fu et al.
Tumor angiogenesis plays a crucial role in tumor metastasis as it provides uninterrupted supply of oxygen and nutrients to the rapidly growing tumor cells. The Food and Drug Administration (FDA) recommends that anti-angiogenesis should be u...
Hydration-dependent mechanics and structural resilience of jelly fungi as natural blueprints for bioinspired hydrogels [0.03%]
Soroosh Salehi,Christopher P Bivins,Debora Lyn Porter
Soroosh Salehi
Jelly fungi function as natural hydrogels capable of tolerating extreme hydration changes and large deformation, making them valuable models for resilient soft materials. This study examines the mechanical behavior of Exidia glandulosa and ...
A bioengineered recombinant spider silk provides targeted G-protein-coupled receptor activation [0.03%]
Anupama Ghimire,Sae Yeon Lee,Andrew A Y Chen et al.
Anupama Ghimire et al.
Spider silks are renowned for exceptional mechanical properties and as promising biomaterials. Here, we introduce a recombinant chimeric protein (W2Cma2ap-55) composed of two aciniform silk repetitive units (W2), a major ampullate silk non-...
THE EFFECT OF PERFUSION WITH AND WITHOUT MECHANICAL LOADING ON AN IN VITRO MODEL OF THE OUTER ANNULUS FIBROSUS-CARTILAGE ENDPLATE INTERFACE [0.03%]
Campbell Thom,J Paul Santerre,Rita A Kandel
Campbell Thom
Intervertebral disc (IVD) degeneration is a prevalent condition contributing to lower back pain, with limited treatment options that fail to restore full disc function. Tissue engineering shows promise, but most work relies on static cultur...
Self-reinforced architecture design for simultaneously transparent and tough sheep horn sheath [0.03%]
兼具透明和坚韧的羊角鞘自增强结构设计
Chen Zhang,Haotian Yu,Zeping Hu et al.
Chen Zhang et al.
Biological systems exhibit extraordinary abilities to synthesize multifunctional materials. The inner layer of the natural sheep horn sheath simultaneously demonstrates high transparency and high toughness, a combination that represents a t...
Hydrophilic cationic surface modification confers simultaneous antibacterial and antithrombotic properties to blood-contacting devices [0.03%]
亲水阳离子表面改性赋予血液接触装置同时的抗菌和抗凝血性能
Yueze Hong,Jingze Liu,Jiaqi Wang et al.
Yueze Hong et al.
The clinical application of blood-contacting medical devices carries lethal risks such as sepsis and vascular embolism, with thrombosis and bacterial infection being core complications that severely threaten device safety. Although cationic...
Slippery by design: Mechanistic insights and biomedical applications of zwitterionic polymer interfaces [0.03%]
巧妙的设计：两性离子聚合物界面的机理见解及生物医学应用
Shuai Jiang,Yanxin Zhang,Xinran Hu et al.
Shuai Jiang et al.
The low-friction property of interfaces is indispensable for both sustaining normal physiological functions and enabling diverse biomedical applications, serving as a critical underpinning for processes spanning joint movement, cellular tra...
Addition of a collagen mimetic peptide to octacalcium phosphate/gelatin composites enhances bone formation by accelerating calcification [0.03%]
胶原模拟肽添加到八钙磷酸盐/明胶复合材料通过加速矿化来增强骨形成
Kento Harada,Ryo Hamai,Yu Mori et al.
Kento Harada et al.
Octacalcium phosphate/gelatin (OCP/Gel) composites exhibit osteogenicity primarily due to OCP bioactivity; however, further improvement of their capacity is necessary for various bone defects. This study was conducted to investigate whether...
Subarachnoid trabeculae suppress cerebrospinal fluid pressurization during translational impact loading using instrumented biomimetic head surrogates [0.03%]
亚arachnoid trabeculae在瞬时翻译冲击载荷下使用仪器化的类脑模型抑制脑脊液压力化
David Bates,Yating Shi,Qifu Wang et al.
David Bates et al.
Traumatic brain injury (TBI) is a global health concern. Cerebrospinal fluid (CSF) dynamics play a key role in the injury process but remain poorly understood due to experimental challenges imposed by the opaque skull and subarachnoid trabe...
Development of a nanocement platform for site-specific antibiotic delivery in skeletal tuberculosis [0.03%]
用于骨骼结核局部递送抗生素的纳米水泥平台的开发
Irfan Qayoom,Purva Gupta,Abhishek Dash et al.
Irfan Qayoom et al.
Osteoarticular tuberculosis infection in spine, hip, and knee is the most common bone and joint extrapulmonary tuberculosis (EPTB), accounting for 10-15% of all EPTB cases. The urgent need for new treatment strategies arises from the severe...