Multiscale Imaging Reveals Compartment-Specific Mechanobiology of the Osteochondral Unit in Knee Osteoarthritis [0.03%]
多尺度成像揭示膝关节骨关节炎中骨软骨单元的室特异性机械生物学现象
Alexander Simon,Victoria Simon,Assil-Ramin Alimy et al.
Alexander Simon et al.
Mechanical overloading is a key risk factor for knee osteoarthritis (OA), yet its compartment-specific effects on the mechanobiology of the osteochondral unit and its interplay with synovial inflammation remain insufficiently defined. Here,...
Calcium Ion-mediated Silk Bulk Materials with Adaptive Mechanics and Intrinsic Osteogenic Activity for Bone Regeneration [0.03%]
钙离子介导的丝素材料具有适应性和内在骨诱导性促进骨组织修复与再生
Xin Yu,Jiujie Xia,Min Wang et al.
Xin Yu et al.
The development of protein-based orthopedic biomaterials that integrate high performance with robust bioactivity for bone regeneration remains challenging. Here, inspired by ion-mediated natural silk spinning and calcium-mediated bone regen...
Hyaluronic acid-coated metal-organic framework for co-delivery of Sirtuin 3 gene and zinc to inhibit liver fibrosis [0.03%]
负载透明质酸的金属有机骨架材料协同递送Sirtuin 3基因和锌抑制肝纤维化
Jisun Jung,Minyoung Jin,Naeun Park et al.
Jisun Jung et al.
Liver fibrosis is characterized by excessive accumulation of extracellular matrix and disruption of hepatic sinusoidal architecture. However, effective therapies targeting microvascular dysfunction and immune imbalance remain limited. In th...
Endocytosis-Dependent and Spleen-Selective mRNA Expression Enabled by Ionizable Lipidoid Linkers Enhances Therapeutic mRNA Vaccination [0.03%]
依赖内吞作用的脾脏选择性mRNA表达使治疗性mRNA疫苗增强效果
Lin Shi,Feng You,Zhihong Sun et al.
Lin Shi et al.
mRNA therapy offers precise control, scalability, and a favorable safety profile, making it a promising modality for disease treatment. However, its clinical success critically depends on effective mRNA delivery systems. Currently approved ...
Enveloped Lipopeptide Vectors Mimic Viral Dual Entry Routes via Endocytosis and Membrane Penetration for Efficient Macromolecule Delivery [0.03%]
一种模仿病毒双输入途径的包膜脂肽载体通过内吞作用和细胞穿透实现大分子高效递送
Jin Yang,Yachao Li,Zenan Zeng et al.
Jin Yang et al.
The therapeutic success of biomacromolecular drugs is fundamentally limited by their poor bioavailability, particularly in hard-to-deliver cells and poorly permeable tissues. To address these challenges, we developed virus-inspired lipopept...
A tumor-microenvironment-adaptive peptide-based nanophotothermal agent for synergistic photothermal-immunotherapy [0.03%]
一种用于协同光热免疫治疗的肿瘤微环境自适应肽基纳米光热制剂
Hong Ju,Zhiyu Han,Tongtong Chen et al.
Hong Ju et al.
Photothermal therapy (PTT) has attracted considerable attention in cancer treatment due to its noninvasive nature and lack of drug resistance. However, conventional photothermal agents often exhibit poor tumor accumulation, nonspecific ther...
Physiological metal-based nanoparticles as bioactive agents for antimicrobial activity and wound repair: Strategies for hydrogel-mediated delivery [0.03%]
生理金属基纳米颗粒作为抗菌和伤口修复生物活性剂：水凝胶介导输送的策略
Laure Brice,Louise Ortet,Sylvie Fournel et al.
Laure Brice et al.
The emergence of antibiotic resistance calls for the discovery of new compounds and materials that can stem the growth of microorganisms and promote wound healing. Metals have long been used for their antimicrobial properties. However, conc...
Hydrogel Engineering for Myocardial Infarction Repair: From Material Design to Functional Mechanisms and Translational Perspectives [0.03%]
心脏修复的水凝胶研究：从材料设计到功能机制和转化前景
Chuanyi Tang,Yu Wu,Manlian Wang et al.
Chuanyi Tang et al.
Myocardial infarction (MI) remains a leading cause of cardiovascular-related morbidity and mortality worldwide. Its primary pathophysiological cascade involves the ischemic and hypoxic necrosis of cardiomyocytes (CMs), the degradation of th...
Will Zhang,Filip Jezek,Anthony J Baker et al.
Will Zhang et al.
While previous studies have characterized the impact of nonlinearity, anisotropy, and viscoelasticity on myocardial mechanics, calcium itself has been thought to primarily affect the active, not passive, mechanics. Recent experimental studi...
Dual-enzyme cascade protein hydrogel membrane orchestrates metabolism-immunity coupling for diabetic wound repair [0.03%]
双酶级联蛋白水凝胶膜 orchestrate代谢免疫耦合促进糖尿病伤口修复
Xing Liu,Liping Wang,Jia Bai et al.
Xing Liu et al.
Diabetic wounds present a formidable clinical challenge due to a self-amplifying network of hyperglycemia-driven microenvironmental dysregulation, including hypoxia, oxidative stress, chronic inflammation, and persistent infection. Existing...