Matrix mechanics couple contractility to metabolic adaptation in cancer cells [0.03%]
矩阵力学使收缩与代谢适应在癌细胞中相互作用
Joshua M Toth,Anuja Jaganathan,Ramin Basir et al.
Joshua M Toth et al.
Cells dynamically regulate their morphology, contractility, and metabolism in response to the mechano-chemical properties of their microenvironment. Here, we show matrix stiffness and ligand density jointly govern the bioenergetics of contr...
Porous ZnO/Zn scaffolds fabricated using binder-jetting 3D printing promote bone regeneration: in vitro and in vivo evidence [0.03%]
使用粘结剂喷射3D打印制备多孔ZnO / Zn支架可促进骨再生：体内外证据
Zhiqiang Lin,Shiya Zhu,Yutian Wu et al.
Zhiqiang Lin et al.
Additive manufacturing offers an effective approach for fabricating biodegradable porous scaffolds that can adapt to the mechanical properties of jawbones. Zinc (Zn) and its alloys are considered promising degradable materials due to their ...
Potential-gradient reprogramming of zinc-based membranes for orthopedic applications [0.03%]
基于锌的潜在梯度重编程膜在骨科中的应用
Dan Jiang,Zhang-Zhi Shi,Wei Gou et al.
Dan Jiang et al.
Zn-based materials degrade in vitro at rates of
Wavy geometry controls nuclear morphology, migration, and YAP signaling independent of myosin II contractility [0.03%]
无肌动蛋白II收缩作用的波浪几何学独立控制核形态、迁移和YAP信号通路
Pen-Hsiu Grace Chao,Bor-Lin Huang,Chin-Hsun Huang et al.
Pen-Hsiu Grace Chao et al.
Cell morphology and mechanics are tightly coupled to extracellular matrix (ECM) geometry, yet how non-linear topographies regulate intracellular organization and phenotype remains unclear. Here, we use microfabricated wavy patterns to recap...
Nanostructured coatings on soft-polymer based neural probes for addressing neuroinflammation [0.03%]
纳米结构涂层软聚合物神经探针对抗神经炎症
Mali Ya Mungu Ocoko,Niveda Kasthuri,Isabella Lugo et al.
Mali Ya Mungu Ocoko et al.
Intracortical microelectrodes (IMEs) record neural activity with single- and multi-unit resolution and interface with brain-machine interfaces (BMIs) to control assistive devices. Long-term performance, however, remains limited by neuroinfl...
Cross-scale biomimicry of resilin and resilin-like proteins: From phase separation and dityrosine photocrosslinking to tissue repair and soft robotic devices [0.03%]
类 resilin 和 resilin 衍生物的跨尺度仿生：从相分离和邻苯二酚光交联到组织修复与软体机器人装置
Xinglin Chen,Jinping Chen,Junrong Zhang et al.
Xinglin Chen et al.
Resilin and resilin-like proteins (RLPs) provide a programmable platform for bioinspired soft materials that spans molecular design, condensate microstructures, and device-level function. This review advances a cross-scale "write-then-lock"...
Long-term remodeling of compliance matched tissue engineered vascular grafts is sex specific [0.03%]
长期匹配顺应性的组织工程血管移植物的重塑具有性别差异性
Katarina M Martinet,David R Maestas Jr,Leon X Min et al.
Katarina M Martinet et al.
Compliance matching of tissue engineered vascular grafts (TEVGs) is a promising technique to combat common failure modes seen clinically in small diameter vascular procedures like coronary artery bypass grafting (CABG). However, despite the...
Ultrasound-activated piezoelectric nanoparticles suppress glycolysis for precision therapy of stress-associated breast cancer [0.03%]
应激相关乳腺癌精确诊疗的超声激活压电纳米粒子抑制糖酵解
Run Yang,Haoyu Jiang,Dawei Zhang et al.
Run Yang et al.
Chronic stress has emerged as a critical factor that exacerbates cancer progression, yet its underlying mechanisms and targeted therapeutic strategies remain elusive. Herein, we demonstrate that restraint-induced stress significantly enhanc...
Nonlinear Relationships of Fibrin Network Structure as a Function of Fibrinogen and Thrombin Concentrations for Purified Fibrinogen and Plasma Clots [0.03%]
关于纯化纤维蛋白原和血浆凝块的纤维蛋白网络结构作为纤维蛋白原和凝血酶浓度函数的非线性关系
Can Cai,Zezhong Zhang,Arezoo Nameny et al.
Can Cai et al.
Background: Fibrinogen levels are associated with bleeding disorders and thrombotic disease. Thrombin converts fibrinogen to fibrin, producing the load-bearing fibrin scaffold that governs clot mechanics and transport. ...
Matrix permissiveness regulates 3D confinement of fibroblasts in biosynthetic hydrogel microenvironments [0.03%]
基质容许性调节成纤维细胞在生物合成水凝胶微环境中的三维限制效应
Indira Priyadarshani Patra,Muthulakshmi Kannan,Saujanya Sabarinath et al.
Indira Priyadarshani Patra et al.
The extracellular matrix (ECM) is a major regulator of cellular behavior, fate, and various mechanisms underlying homeostasis, development, and disease. Biophysical and biochemical properties of the ECM are known to affect three-dimensional...