Ultrasound-Mediated Blockade of Nociceptive Transmission by Targeted Liposomes for Efficient Cancer Pain Therapy [0.03%]
声控靶向脂质体阻断癌痛动物 nociceptive 传入神经治疗癌痛
Yaqian Du,Zixuan Huang,Xiaodan Xu et al.
Yaqian Du et al.
The lack of pain management for advanced pancreatic cancer resulted in severe suffering for patients at the final stage of life. Pain relief can be achieved through local injection of nerve-blocking agents, but the efficiency was attenuated...
Fluorinated ROS-Responsive Polycation Enables Noninvasive siRNA Delivery for the Treatment of Corneal Neovascularization [0.03%]
可用于治疗角膜新生血管的非侵入性siRNA传递的ROS响应型聚阳离子的研究
Yifei Chen,Xin Wang,Yong Duan et al.
Yifei Chen et al.
Corneal neovascularization (CNV) is a vision-threatening condition characterized by abnormal blood vessel growth into the avascular cornea, impairing its transparency and visual function. CNV is driven by an imbalance between pro- and anti-...
Multi-Targeted ROS-Responsive Self-Immolative Nanoparticles for Releasing Hydrogen Sulfide and In Situ Binding of Cell-Free DNA in Blast-Induced Acute Lung Injury [0.03%]
用于爆炸引起的急性肺损伤的ROS响应型自消解纳米颗粒释放硫化氢及结合胞外DNA多功能治疗
Ying Li,Yiting Yin,Duo Li et al.
Ying Li et al.
Blast accidents are common in daily life and industrial settings and frequently result in acute lung injury (ALI), which may progress to respiratory failure in severe cases. Beyond the initial mechanical insult, dysregulated inflammatory re...
3D Digital Light Processing Bioprinting and In Situ Differentiation of hiPSCs for Engineering Cardiac Tissue [0.03%]
用于工程心脏组织的hiPSCs在体分化及基于DLP的生物打印技术
Aihik Banerjee,Kevin Dalsania,Jonah Damian et al.
Aihik Banerjee et al.
The lack of physiologically relevant, reliable, scalable human cardiac tissue models remains a major barrier in cardiovascular disease research and drug development. Conventional 2D culture systems and animal models fail to accurately recap...
Friederike Kaiser,Lena Schröter,Anita Ignatius et al.
Friederike Kaiser et al.
When bone defects surpass a critical threshold in size, they typically necessitate intervention through either autologous bone grafting or the use of synthetic substitutes to maintain structural support and prevent unwanted soft tissue infi...
Harnessing Extracellular Vesicles for Endochondral Bone Regeneration: Mechanisms and Applications [0.03%]
外泌体促进软骨下骨再生的机制及应用研究
Flurina Staubli,Yinghong Zhou,Pieter Vader et al.
Flurina Staubli et al.
Developmentally inspired strategies that recapitulate endochondral ossification (EO), the physiological mechanism underlying secondary fracture repair, are emerging as promising approaches for bone regeneration. Extracellular vesicles (EVs)...
Advances in Ocular Implants: From Geometry Design to Controlled Drug Release Mechanisms [0.03%]
眼用植入物的进展：从几何设计到控制药物释放机制
Hongshuang Liu,Jiani Zhou,Lin Du et al.
Hongshuang Liu et al.
The unique physiological barriers within the eye greatly impede the effective delivery of traditional drug therapies to specific intraocular target sites, leading to low bioavailability and a short duration of action. Intraocular implants p...
Restoring Antitumor Immunity by Reprogramming Abnormal Lipid Metabolism in the Tumor Microenvironment Using Irisin-Manganese Co-loaded Nanoparticles [0.03%]
采用irisin-锰共载纳米颗粒重编程肿瘤微环境的异常脂质代谢以恢复抗肿瘤免疫
Xingzhe Tang,Yufei Zhao,Yan Gu et al.
Xingzhe Tang et al.
Targeting dysregulated lipid metabolism within the tumor microenvironment (TME) has emerged as a promising strategy for restoring anti-tumor immunity and reversing immune suppression to improve therapeutic efficiency. This study reports a n...
Commensal microflora coating endows implants with biofilm-repellent, immunomodulatory and osteogenic properties [0.03%]
共生微生物包衣赋予植入物生物膜排斥性，免疫调节性和成骨性能
Muhammad Imran Rahim,Shehneela Baseer,Daniela Paasch et al.
Muhammad Imran Rahim et al.
Bacteria often form biofilms on biomaterials, and these biomaterial-associated infections then become highly resistant to antibiotics and the host immune system. Biofilm-driven implant failures underscore the urgent need for surface modific...
Matrix-Modulating pH-Gated Hydrogel for Coordinated Regulation of Cancer-Associated Fibroblast Phenotype and Mn²⁺-STING Activation for Enhanced Tumor Immunotherapy [0.03%]
一种矩阵调节的pH门控水凝胶，可协同调控肿瘤相关成纤维细胞表型和Mn²⁺-STING活化，以增强肿瘤免疫治疗
Tinghua Li,Yazhen Wang,Jiahui Zhu et al.
Tinghua Li et al.
The tumor microenvironment (TME), particularly its cancer-associated fibroblast (CAF)-driven fibrotic stroma and immunosuppressive components, forms intertwined physical and immune barriers that impede the efficacy of immunotherapy. To addr...