Targeting Neuromyelitis Optica Pathogenesis: Results from Randomized Controlled Trials of Biologics [0.03%]
靶向神经肌炎谱系疾病发病机制：生物制剂的随机对照试验结果
Laura Cacciaguerra,Paola Tortorella,Maria A Rocca et al.
Laura Cacciaguerra et al.
Advances in neuromyelitis optica spectrum disorder pathogenesis have allowed the development of targeted drugs. These treatments act on core elements of the disease, including the pro-inflammatory IL-6 pathway (tocilizumab and satralizumab)...
Correction to: Selective Immunomodulatory and Neuroprotective Effects of a NOD2 Receptor Agonist on Mouse Models of Multiple Sclerosis [0.03%]
Correction to：NOD2受体激动剂对多发性硬化小鼠模型的选择性免疫调节和神经保护作用
Adham Fani Maleki,Giulia Cisbani,Nataly Laflamme et al.
Adham Fani Maleki et al.
Network Substrates of Centromedian Nucleus Deep Brain Stimulation in Generalized Pharmacoresistant Epilepsy [0.03%]
丘脑中央中核深部电刺激治疗难治性全面性癫痫的作用机制及网络效应研究
Cristina V Torres Diaz,Gabriel González-Escamilla,Dumitru Ciolac et al.
Cristina V Torres Diaz et al.
Deep brain stimulation (DBS), specifically thalamic DBS, has achieved promising results to reduce seizure severity and frequency in pharmacoresistant epilepsies, thereby establishing it for clinical use. The mechanisms of action are, howeve...
A practical guide to the pharmacological and behavioral therapy of Narcolepsy [0.03%]
narcolepsy的药理和行为疗法实用指南
Christian Franceschini,Fabio Pizza,Francesca Cavalli et al.
Christian Franceschini et al.
Narcolepsy is a rare, chronic, and disabling central nervous system hypersomnia; two forms can be recognized: narcolepsy type 1 (NT1) and narcolepsy type 2 (NT2). Its etiology is still largely unknown, but studies have reported a strong ass...
The Antipsychotic Drug Clozapine Suppresses the RGS4 Polyubiquitylation and Proteasomal Degradation Mediated by the Arg/N-Degron Pathway [0.03%]
抗精神病药物氯氮平通过抑制Arg/N-degron途径介导的RGS4多泛素化和蛋白酶体降解来稳定RGS4蛋白表达
Jun Hyoung Jeon,Tae Rim Oh,Seoyoung Park et al.
Jun Hyoung Jeon et al.
Although diverse antipsychotic drugs have been developed for the treatment of schizophrenia, most of their mechanisms of action remain elusive. Regulator of G-protein signaling 4 (RGS4) has been reported to be linked, both genetically and f...
A Milestone in Multiple Sclerosis Therapy: Monoclonal Antibodies Against CD20-Yet Progress Continues [0.03%]
多发性硬化治疗的里程碑：抗CD20单克隆抗体——进展仍在继续
Esther S Frisch,Roxanne Pretzsch,Martin S Weber
Esther S Frisch
Multiple sclerosis (MS), which is a chronic inflammatory disease of the central nervous system, still represents one of the most common causes of persisting disability with an early disease onset. Growing evidence suggests B cells to play a...
Thomas R Gossard,Lynn Marie Trotti,Aleksandar Videnovic et al.
Thomas R Gossard et al.
Restless legs syndrome (RLS) is characterized by an uncomfortable urge to move the legs while at rest, relief upon movement or getting up to walk, and worsened symptom severity at night. RLS may be primary (idiopathic) or secondary to pregn...
Ethical Considerations in Communicating Alzheimer's Disease Neuroimaging Biomarker Test Results to Symptomatic Individuals [0.03%]
告知有症状个体阿尔茨海默病神经影像生物标志检测结果的伦理考量
Daniel A Wilkenfeld,Staci L Orbell,Jennifer H Lingler
Daniel A Wilkenfeld
This article examines ethical issues associated with the return of AD neuroimaging results to cognitively symptomatic individuals. Following a review of research on patient and study partner reactions to learning the results of biomarker te...
Reconditioning the Neurogenic Niche of Adult Non-human Primates by Antisense Oligonucleotide-Mediated Attenuation of TGFβ Signaling [0.03%]
反义寡核苷酸介导转化生长因子β信号通路衰减可重塑成年非人灵长类动物的神经发生生态位
Sebastian Peters,Sabrina Kuespert,Eva Wirkert et al.
Sebastian Peters et al.
Adult neurogenesis is a target for brain rejuvenation as well as regeneration in aging and disease. Numerous approaches showed efficacy to elevate neurogenesis in rodents, yet translation into therapies has not been achieved. Here, we intro...