Safety and efficacy of Igk-TATk-CDKL5 gene therapy in mosaic CDKL5 deficiency [0.03%]
Igk-TATk-CDKL5基因治疗在镶嵌型CDKL5缺陷症中的安全性和有效性研究
Giorgio Medici,Marianna Tassinari,Manuela Loi et al.
Giorgio Medici et al.
CDKL5 Deficiency Disorder (CDD) is a severe neurodevelopmental disorder caused by mutations in the X-linked CDKL5 gene, resulting in early-onset seizures, developmental delays, and cognitive and sensorimotor impairments. While emerging ther...
Stress-induced nuclear GAPDH: Scientific update and clinical application [0.03%]
应激诱导的核GAPDH：科学研究与临床应用
Parimala Vedula,Koko Ishizuka,Arisa Hayashida et al.
Parimala Vedula et al.
Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is known as a moonlighting protein beyond its original glycolytic function. Stress-induced nuclear translocation of GAPDH has been reproducibly reported, which results in variety types of cel...
Multi-tracer PET and MR imaging visualize distinct metabolic and inflammatory profiles in the white matter of NMOSD and MOGAD [0.03%]
多示踪剂正电子发射断层扫描和磁共振成像揭示NMOSD和MOGAD患者白质中不同的代谢及炎症特征
Shuwei Bai,Hongda Shao,Hong Yang et al.
Shuwei Bai et al.
This study investigates distinct neuroinflammatory patterns in neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) using multi-tracer PET and MR imaging. Eight NMOSD (5F/3M; median...
Profiling the landscape of cysteine posttranslational modifications in brain aging and neurodegeneration [0.03%]
脑衰老和神经退行性疾病中蛋白质半胱氨酸位点非酰基化修饰的图谱测绘
Milos R Filipovic
Milos R Filipovic
Cysteine residues occupy a unique position in the proteome: their thiolate side chain combines high nucleophilicity with redox sensitivity, making them prime targets for a diverse and ever-expanding array of post-translational modifications...
Tumor treating fields alter local coagulation dynamics in glioblastoma patients [0.03%]
肿瘤治疗场改变胶质母细胞瘤患者的局部凝血动力学
Claudia Maletzki,Thomas Freitag,Adrian Hempelmann et al.
Claudia Maletzki et al.
Glioblastoma (GBM) is a highly aggressive brain tumor, associated with hypercoagulability and thrombosis. Tumor Treating Fields (TTFields), a non-invasive therapy that uses low-intensity, alternating electric fields to disrupt cancer cell d...
Targeting Talin1 to reprogram dendritic cell activation landscapes: A mechanistically grounded cell therapy for multiple sclerosis model [0.03%]
靶向Talin1重新编程树突状细胞激活景观：一种针对多发性硬化症模型的基于机制的细胞疗法
Jia Liu,Xiaorui Guan,Zhen Jia et al.
Jia Liu et al.
This study investigated the role of Talin1 in regulating dendritic cell (DC) activation and the neuroprotective benefits of Talin1-knockdown DCs in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS)....
Cyanide overproduction impairs cellular bioenergetics in Down syndrome [0.03%]
细胞生物能量学受损导致唐氏综合症患者氰化物过量产生
Maria Petrosino,Karim Zuhra,Anna Kieronska-Rudek et al.
Maria Petrosino et al.
Cyanide exerts its toxic effects primarily by inhibiting mitochondrial Complex IV (Cytochrome c oxidase, CCOx). Recent studies have shown that mammalian cells can endogenously produce cyanide from glycine via a lysosomal pathway. At low con...
Hypoperfusion intensity ratio is associated with follow-up infarct volume in medium vessel occlusions: A multicenter multinational study [0.03%]
中血管闭塞患者低灌注强度比与随访梗死体积相关性研究：多中心跨国研究
Vivek Yedavalli,Hamza Adel Salim,Dhairya Lakhani et al.
Vivek Yedavalli et al.
Medium vessel occlusion (MeVO) contributes significantly to acute ischemic stroke (AIS). The hypoperfusion intensity ratio (HIR), reflecting collateral circulation via the ratio of Tmax >10s to Tmax >6s volumes, predicts infarct progression...
Gaultheria leucocarpa inhibits Aβ fibrillization and enhances mitophagy-mediated degradation of pathogenic proteins [0.03%]
高新青梅通过抑制Aβ纤维化和促进线粒体自噬介导的病理蛋白质降解改善阿尔茨海默病症状
Yue Zhang,Lan Deng,Jing Wei et al.
Yue Zhang et al.
Alzheimer's disease (AD) pathology involves amyloid-beta (Aβ) accumulation and neuronal toxicity, highlighting the need for therapeutic strategies that can both inhibit Aβ aggregation and promote pathogenic protein clearance. In this stud...
Asparagine endopeptidase (AEP) inhibitor formulation via zein-based nanoparticle improves the therapeutic efficacy toward Alzheimer's disease [0.03%]
基于玉米醇溶蛋白的纳米颗粒载体的天冬酰胺内肽酶(AEP)抑制剂改善治疗阿尔茨海默病的疗效研究
Xin Meng,Mengmeng Wang,Menghan Yang et al.
Xin Meng et al.
Asparagine endopeptidase (AEP) plays a critical role in Alzheimer's disease (AD) by cleaving amyloid precursor protein (APP) at N585 and tau protein at N368. Genetic deletion or pharmacological inhibition of AEP using compound 11a ameliorat...