PEBP1 inhibition as a therapeutic target for neurological recovery in ischemic stroke [0.03%]
缺血性卒中患者神经功能恢复的治疗靶点PEBP1抑制作用研究
Yu-Qian Niu,Ze-Yu Cai,Hao-Yang Zhi et al.
Yu-Qian Niu et al.
Ischemic stroke poses a substantial clinical and socioeconomic burden due to limited therapeutic efficacy and poor neurological outcomes. To uncover novel gene targets for intervention, we conducted an integrative analysis combining single-...
Treatment approaches to patients with multiple sclerosis and coexisting psoriasis - A longitudinal multicenter observational cohort study [0.03%]
多发性硬化合并银屑病患者的治疗状况——一项纵向多中心队列观察研究
Tobias Brummer,Saskia Räuber,Jasmin Jakob et al.
Tobias Brummer et al.
Neurologists frequently encounter multiple sclerosis (MS) patients with coexisting autoimmune disorders such as psoriasis (PsO). The evolving landscape of immunotherapies has made treatment decisions more complex, yet also opened opportunit...
Bilateral intermittent theta burst stimulation over the primary motor cortex improves motor and affective symptoms via thalamic network reintegration in mid-stage Parkinson's disease [0.03%]
双边间歇theta burst刺激初级运动皮质通过丘脑网络整合改善中期帕金森病的运动和情感症状
Paloma Macías-García,Raúl Rashid-López,Álvaro J Cruz-Gómez et al.
Paloma Macías-García et al.
Bilateral intermittent theta burst stimulation (iTBS) targeting the primary motor cortex (M1) has emerged as a promising neuromodulatory approach for Parkinson's disease (PD), although evidence supporting its clinical efficacy as an adjunct...
Leptin antagonism improves Rett syndrome phenotype in symptomatic Mecp2-deficient mice [0.03%]
脂联素抗原改善甲基 CpG 结合蛋白 2 缺陷的症状型突变小鼠的雷特综合征表型
Yasmine Belaïdouni,Diabe Diabira,Pascal Salin et al.
Yasmine Belaïdouni et al.
Rett syndrome (RTT) is a severe X-linked neurodevelopmental disorder caused by mutations in MECP2. Elevated circulating levels of the adipocyte hormone leptin are consistently observed in patients and in mouse models, yet their contribution...
Involvement of trimethylamine N-oxide in major depressive disorder via astrocytic d-Serine dysregulation [0.03%]
三甲胺N-氧化物通过天冬氨酸调节胶质细胞d-丝氨酸失调参与主要抑郁障碍
Liwang Lin,Longyu Li,Shiao Ren et al.
Liwang Lin et al.
Trimethylamine N-oxide (TMAO), a co-metabolite of the gut microbiota and host, has been implicated in the pathogenesis of various neuropsychiatric disorders. However, its role in major depressive disorder (MDD) remains poorly understood. Th...
Targeting enhancing myelin regeneration reverses cognitive deficits in a mouse model of intellectual disability [0.03%]
靶向增强髓鞘再生可逆转智力障碍小鼠模型的认知缺陷
Pingping Qiao,He Wang,Pingping Qu et al.
Pingping Qiao et al.
The early postnatal period is a critical window for brain maturation, during which oligodendrogenesis, myelination, and synaptogenesis are dynamically orchestrated to support cognitive development. Clinical studies have associated myelinati...
Neuroprotective therapy after traumatic brain injury: does the window for treatment extend for months? [0.03%]
创伤性脑损伤后的神经保护治疗：治疗时间窗是否可延长数月？
Cillian Lynch,Ramon Diaz-Arrastia
Cillian Lynch
Dual antiplatelet therapy in acute ischemic stroke: Does diabetes mellitus define a target population? [0.03%]
糖尿病患者急性缺血性卒中的双联抗血小板治疗：是否需要针对这一人群制定特定方案？
Simona Nedelcu
Simona Nedelcu
RNA-binding protein MBNL2 mitigates neuropathic pain after chemotherapy through destabilizing CCR2 expression in primary sensory neurons [0.03%]
RNA结合蛋白MBNL2通过降低初级感觉神经元中CCR2的表达来缓解化疗后神经痛
Keshi Yan,Ruining Ma,Bing Wang et al.
Keshi Yan et al.
Chemotherapy drug-induced changes of gene expression in the dorsal root ganglion (DRG) are critical for the genesis of chemotherapy-induced neuropathic pain (CINP). However, the mechanisms driving these changes remain elusive. Here, we repo...
Jason Yuen,Aaron Loh,Ghazaleh Darmani et al.
Jason Yuen et al.
Chronic craniofacial pain can lead to significant morbidity and reduced quality-of-life. Refractory pain subsequently leads to maladaptive changes within the central nervous system (CNS). It is logical to consider modulation of implicated n...