Targeted ErbB4 receptor activation ameliorates neuronal deficits via DOCK3 signaling in a transgenic mouse AD model [0.03%]
靶向激活ErbB4受体通过DOCK3信号改善转基因AD小鼠的神经元缺陷
Chong Liu,Yan Zhao,Ji-Ji Dao et al.
Chong Liu et al.
Accumulating evidence has highlighted the critical involvement of ErbB4 receptor in the onset and progression of Alzheimer's disease (AD). Utilizing a small molecule ErbB4 receptor agonist (E4A) identified through virtual screening, it was ...
Antibody targeting TDP-43 mitigates pathogenic pathways induced by the cerebrospinal fluid of ALS [0.03%]
抗TDP-43抗体可缓解由ALS脑脊液诱导的病理途径
Amélie Poulin-Brière,Silvia Pozzi,Jean-Pierre Julien
Amélie Poulin-Brière
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease characterized by the cytoplasmic mislocalization and accumulation of TAR DNA binding protein 43 (TDP-43). We reported previously the protective effects in a trans...
The polyunsaturated fatty acid and oxylipin plasma signature of aneurysmal subarachnoid haemorrhage, case-control study [0.03%]
动脉瘤性蛛网膜下腔出血的血浆多不饱和脂肪酸和氧化脂质谱研究：病例对照研究
M A Franssen,M A Tjerkstra,M Heijink et al.
M A Franssen et al.
Delayed cerebral ischemia (DCI) following aneurysmal subarachnoid haemorrhage (aSAH) is a complex and acute condition with limited options for early detection and effective treatments. The plasma levels of individual polyunsaturated fatty a...
The GPR120 agonist TUG-891 mitigates ischemic brain injury by attenuating endoplasmic reticulum stress and apoptosis via the PI3K/AKT signaling pathway [0.03%]
GPR120激动剂TUG-891通过PI3K/AKT信号通路缓解内质网应激和凋亡进而减轻缺血性脑损伤
Panxi Sun,Lili Wei,Xue Qin et al.
Panxi Sun et al.
Extensive research has confirmed that omega-3 fatty acids provide cardiovascular protection primarily by activating the G protein-coupled receptor 120 (GPR120) signaling pathway. However, natural activators of this receptor often lack suffi...
Efficacy and safety of efgartigimod versus intravenous immunoglobulin in early intervention of acetylcholine receptor antibody-positive impending myasthenic crisis: A retrospective cohort study [0.03%]
乙酰胆碱受体抗体阳性重症肌无力危象前患者早期使用艾加替莫双抗治疗的有效性和安全性：回顾性队列研究
Rongjing Guo,Chao Sun,Xiaoxi Huang et al.
Rongjing Guo et al.
Early intervention in impending myasthenic crisis (IMC) is critical to avert life-threatening progression. This study compared the clinical effectiveness and safety of the novel FcRn antagonist efgartigimod versus intravenous immunoglobulin...
Cellular fibronectin exacerbates α-synuclein aggregation via integrin alpha4beta1 mediated PARP1 and SCD elevation [0.03%]
整合素alpha4beta1介导的PARP1和SCD上调通过细胞外纤维连接蛋白加剧α-突触核蛋白聚集
Zifeng Huang,Hui Zhong,Yingqiong Lu et al.
Zifeng Huang et al.
Mitochondrial dysfunction and lipid metabolic disturbance may promote pathologic α-synuclein (α-syn) aggregation, accelerating the progression of Parkinson's disease (PD). Whether extracellular matrices are associated with those pathologi...
PROTACs therapeutically target the polyglutamine androgen receptor in spinal and bulbar muscular atrophy models [0.03%]
用于脊髓和球部肌肉萎缩模型的 PROTAC 疗法靶向聚谷氨酰胺雄激素受体
Agamjot Sangotra,Satya L Reddy,Curtis J Kuo et al.
Agamjot Sangotra et al.
Spinal and bulbar muscular atrophy (SBMA) is a CAG/polyglutamine (polyQ) repeat expansion disorder in which the mutant androgen receptor (AR) protein triggers progressive degeneration of the neuromuscular system in men. As the misfolded pol...
A double-blind, controlled trial of circadian effective light therapy in patients with Parkinson's disease [0.03%]
帕金森病患者的昼夜有效光疗法的双盲对照试验
Bradley T Wyman,Dan Adams,Suzanne Hendrix et al.
Bradley T Wyman et al.
Despite current medical therapy for Parkinson's Disease (PD), many experience persistent motor symptoms and significant unmanaged non-motor issues. Previous studies suggest that light therapy (LT) provides benefits for motor and non-motor f...