Genotype and subependymal lesion burden influence volumetric response to everolimus in tuberous sclerosis complex-associated subependymal giant cell astrocytoma: A 10-year real-world study [0.03%]
结节性硬化症相关室管膜下巨细胞星形细胞瘤的基因型和亚室管膜下病变负荷影响Everolimus的体积反应：一项为期10年的真实世界研究
Tzu-Hsuan Su,Steven Shinn-Forng Peng,Pei-Lung Chen et al.
Tzu-Hsuan Su et al.
Everolimus, a mechanistic target of rapamycin (mTOR) inhibitor, effectively reduces subependymal giant cell astrocytoma (SEGA) volume in patients with tuberous sclerosis complex (TSC); however, biological determinants of therapeutic sensiti...
Eloisa Rubio-Beltran,Antoinette MaassenVanDenBrink
Eloisa Rubio-Beltran
Migraine is a highly prevalent and disabling neurovascular disorder characterized by recurrent episodes of moderate to severe headache, often accompanied by nausea, photophobia, and phonophobia. A prominent feature of migraine is its dispro...
Investigations of remibrutinib in models pertinent to multiple sclerosis [0.03%]
用于多发性硬化症相关的remibrutinib的研究模型中的研究
Rajiv W Jain,Atefeh Rayatpour,Kathleen Hagen et al.
Rajiv W Jain et al.
Inhibitors of Bruton tyrosine kinase (BTK) are actively being pursued as potential disease-modifying therapies for multiple sclerosis (MS), as attested by several completed or ongoing Phase 3 clinical trials. Yet, key aspects of BTK inhibit...
Strategic consensus on the clinical translation of advanced therapies in paediatric rare neurological disorders [0.03%]
儿科罕见神经疾病的先进治疗临床转化的战略共识
Natalie Y Lim,Christian E Meagher,Ann Bye et al.
Natalie Y Lim et al.
Advanced therapies (ATs), including gene and stem cell therapy, hold great potential for preventing and ameliorating many rare neurological disorders (RNDs) in children. These technologies are set to expand across modalities, potentially di...
A phase 1, safety, tolerability, and pharmacokinetics study of bisnorcymserine, a highly selective inhibitor of butyrylcholinesterase [0.03%]
倍氨胆碱酯酶强选择性抑制剂双氮基西梅林的I期临床研究：药物动力学、安全性和耐受性
Iason Tzieras,Apostolos Manolopoulos,David Tweedie et al.
Iason Tzieras et al.
Cholinergic deficiency is a hallmark neurotransmitter abnormality in Alzheimer's disease (AD) that has traditionally been addressed with cholinesterase inhibitors. In severe AD, butyrylcholinesterase (BuChE) becomes the dominant cholinester...
Pulsed focused ultrasound for seizure suppression: Mechanisms, models, and clinical translation [0.03%]
用于抑制癫痫发作的超声脉冲聚焦：机制、模型和临床转化
Po-Chun Chu,Robert S Fisher,Hao-Li Liu
Po-Chun Chu
Focused ultrasound (FUS) has emerged as a versatile, non-invasive therapeutic platform for drug-resistant epilepsy, offering both thermal effects for the permanent ablation of epileptogenic foci and non-thermal mechanical mechanisms for the...
Modulation of evoked alpha oscillatory activity in the frontocentral region during analgesia by non-invasive brain stimulation [0.03%]
非侵入性脑刺激调节镇痛过程中前中央区诱发的α振荡活动
Nahian S Chowdhury,Samantha K Millard,Enrico De Martino et al.
Nahian S Chowdhury et al.
Background: Repetitive transcranial magnetic stimulation (rTMS) to the posterior superior insula (PSI) can produce analgesia, although the underlying mechanisms require further exploration. While alpha oscillations have b...
A female-specific role for Slit1 in prenatal stress-induced depression vulnerability [0.03%]
prenatal 应激诱导的抑郁易感性中Slit1 的性别特异性作用
Kaixuan Xu,Tu Chen,Yang Yang et al.
Kaixuan Xu et al.
Women experience nearly twice the prevalence of depression compared to men and frequently present with comorbid anxiety, with this divergence emerging during adolescence. However, the molecular mechanisms underlying female-specific depressi...
Telomerase mRNA-Lipid nanoparticles attenuate neuroinflammation after traumatic brain injury in mice [0.03%]
用于治疗小鼠创伤性脑损伤的端粒酶mRNA-脂质纳米颗粒可减轻神经炎症
Goknur Kara,Morgan Holcomb,Anjana Tiwari et al.
Goknur Kara et al.
Traumatic brain injury (TBI) is a leading cause of chronic neurological disability, yet no disease-modifying therapy exists. Emerging evidence indicates that TBI activates cellular aging programs, including telomere erosion and persistent i...
Vihang Nakhate,Gilbert Youssef,Patrick Y Wen
Vihang Nakhate
Isocitrate dehydrogenase (IDH)-mutant gliomas constitute a distinct molecular subtype of diffuse gliomas, characterized by unique biology and relatively favorable clinical outcomes. However, despite their more indolent initial course, these...