FGF17 synergistically targets neuronal survival and oligodendrogenesis to restore stroke deficits [0.03%]
FGF17协同作用靶向神经元存活和少突胶质细胞发生以修复中风缺陷
Yanxuan Li,Xincheng Jiang,Qizhong Chen et al.
Yanxuan Li et al.
Stroke remains a leading cause of long-term disability, and recovery is often limited by impaired neurorestoration and glial scar-mediated inhibition of axonal regeneration. Although fibroblast growth factor 17 (FGF17) regulates oligodendro...
Sotagliflozin improves cognitive deficits and attenuates neuroinflammation of Alzheimer's disease [0.03%]
索塔格利弗林改善阿尔茨海默病的认知缺陷并减轻神经炎症
Yuye Ning,Meilin Chen,Hao Yang et al.
Yuye Ning et al.
Effective treatments for Alzheimer's disease (AD) are limited. Due to shared pathological mechanisms between AD and diabetes, antidiabetic drugs like sodium-glucose cotransporter-2 inhibitors (SGLT2is) are potential therapeutic options. Alt...
Neurological complications of current and emerging CAR-T cell therapies [0.03%]
当前和新兴的CAR-T细胞治疗的神经系统并发症
Anna G Hauswirth,Jorg Dietrich
Anna G Hauswirth
Harnessing an individual patient's immune system to enhance anti-tumor responses has been a long-standing goal in oncology. Multiple immune modulating or immune enhancing therapies have been FDA approved or are under development, utilizing ...
Hemodynamics Beyond Ischemic Zone Underlies Early Neurological Deterioration in Minor Stroke with Large Vessel Occlusion [0.03%]
大血管闭塞性小卒中早期神经功能恶化的发病机制：缺血区周围低灌注的影响
Zhijiao He,Lan Hong,Tingyu Yi et al.
Zhijiao He et al.
Early neurological deterioration (END) occurs in a substantial proportion of minor stroke patients with large vessel occlusion or severe stenosis (LVO/SS) and is a strong predictor of poor outcome, yet its underlying mechanisms remain debat...
Long-term efficacy of subthalamic nucleus deep brain stimulation in focal motor seizures and implications for candidate selection [0.03%]
丘脑底核电刺激治疗局灶性运动性癫痫长期疗效及患者选择指征探讨
Baoxin Xu,Xueyuan Wang,Xiaohua Zhang et al.
Baoxin Xu et al.
Focal motor seizures (FMS) are often unresectable because of motor risk. We aimed to evaluate the long-term effectiveness and safety of subthalamic nucleus deep brain stimulation (STN-DBS) in patients with FMS and to identify suitable candi...
Brain interstitial fluid pharmacokinetics and therapeutic effect of a BBB penetrating amyloid beta antibody measured by microdialysis [0.03%]
通过微透析测量的穿透血脑屏障的淀粉样蛋白β抗体的脑间质液药代动力学和治疗效果
Elin Wik,Amelia D Dahlén,Ulrika Julku et al.
Elin Wik et al.
The disease-modifying antibody lecanemab for treating Alzheimer's disease (AD) was initially designed to target amyloid-beta (Aβ) protofibrils, i.e. soluble aggregates of Aβ, but it has also been successful in clearing insoluble amyloid p...
Meziane Brizini,Sébastien Perreault,Julie Bennett et al.
Meziane Brizini et al.
Pediatric low-grade gliomas (pLGGs), the most common CNS tumors in children, are increasingly recognized as chronic diseases with prolonged courses and cumulative morbidity. Long-term survival is excellent. Management depends on tumor locat...
Zhanwei Zhu,Jian Chen,Jiaxin Hu et al.
Zhanwei Zhu et al.
Salvage of the ischemic penumbra is critical for improving outcomes after stroke, yet effective molecular targets remain elusive. Therapeutic hypothermia (TH) is a promising neuroprotective strategy, but its precise mechanisms, particularly...
Philip M McCarthy,David E Burdette
Philip M McCarthy
Programming of RNS is an iterative process involving a logical progression of patient-specific electrocorticographic biomarker detections that inform stepwise progression of stimulation parameters. In this paper, we discuss the identificati...