Bindu D Paul,Louis J Ignarro,Stuart A Lipton
Bindu D Paul
Commentary: Lysosomal enzymes engineered to cross the blood-brain barrier are reshaping the therapeutic landscape of neuronopathic mucopolysaccharidoses [0.03%]
评论：能穿越血脑屏障的溶酶体酶的工程改造正在重塑神经元病型黏多糖贮积症的治疗格局
Nicolina Cristina Sorrentino,Alessandro Fraldi
Nicolina Cristina Sorrentino
Alexandra R Allam,Evelyn Attia
Alexandra R Allam
Eating disorders, including anorexia nervosa (AN), bulimia nervosa (BN), binge-eating disorder (BED), and avoidant/restrictive food intake disorder (ARFID), are serious psychiatric illnesses treated primarily with psychotherapy focusing on ...
Promising effects of astaxanthin on pain-related behaviors and morphine tolerance in a mouse model of neuropathic pain: Possible involvement of Nrf2 and the NMDA receptor subunit NR2B [0.03%]
虾青素在神经病理性疼痛小鼠模型中的镇痛作用及对吗啡耐受的作用：可能涉及Nrf2和N-甲基-D天冬氨酸受体NR2B亚单位
Katarzyna Ciapała,Katarzyna Pawlik,Agata Ciechanowska et al.
Katarzyna Ciapała et al.
The search for new analgesics remains an important issue because therapy for neuropathic pain is still ineffective. Astaxanthin is a naturally derived compound with well-established antiinflammatory and antioxidant properties; however, its ...
SS-31 improves post-cardiac arrest brain injury by inhibiting microglial ferroptosis and polarization [0.03%]
SS-31通过抑制微胶质细胞铁死亡和极化改善心搏骤停后脑损伤
Tangxing Jiang,Huidan Zhang,Yijun Sun et al.
Tangxing Jiang et al.
Accumulating evidence suggests that ferroptosis and mitochondrial dysfunction contribute significantly to brain injury following cardiac arrest (CA) and resuscitation. SS-31, a novel mitochondria-targeting peptide, has demonstrated protecti...
Risk factors for prolonged mechanical ventilation in critically ill patients with ischemic stroke [0.03%]
缺血性卒中重症患者长时间机械通气的危险因素分析
Jielian Luo,Chen Zhang,Rou Deng et al.
Jielian Luo et al.
Prolonged mechanical ventilation (PMV) is associated with increased morbidity and mortality among critically ill patients with ischemic stroke, yet data on its risk factors remain limited. This study aimed to identify independent predictors...
Paricalcitol-mediated vitamin D receptor activation attenuates neuronal ferroptosis via cAMP-PKA-DRP1 signaling pathway after intracerebral hemorrhage [0.03%]
帕立骨化醇通过cAMP-PKA-DRP1信号途径激活维生素D受体减轻自发性颅内出血后神经元铁死亡
Mi Tian,Xin Li,Dongqing Qi et al.
Mi Tian et al.
The Vitamin D Receptor (VDR) is an emerging therapeutic target for neurological injuries, yet its role in neuronal ferroptosis and mitochondrial dynamics following intracerebral hemorrhage (ICH) remains undefined. This study aimed to determ...
Takehiko Yamanashi,Tsuyoshi Nishiguchi,Gen Shinozaki
Takehiko Yamanashi
Delirium is a frequent complication among older adults and is linked to higher mortality, longer hospital stays, and greater healthcare expenditure. Although its clinical relevance is well recognized, routine diagnosis remains challenging b...
Targeting the mutant androgen receptor with PROTACs in spinal and bulbar muscular atrophy [0.03%]
靶向PROTACs的小脑脊髓共济运动失调中的突变雄激素受体
Changwoo Lee,Janghoo Lim
Changwoo Lee
Effectiveness of Anti-CD20 B cells depleting therapy versus conventional treatment in severe Anti-N-methyl-d-aspartate receptor encephalitis: A real-world multi-center prospective cohort study [0.03%]
抗CD20 B细胞耗竭疗法与常规治疗重度抗N-甲基-D-天冬氨酸受体脑炎的有效性：一项真实世界多中心队列研究
Baojie Wang,Yuxiu Xiao,Yufeng Chu et al.
Baojie Wang et al.
Approximately 25 %-40 % of anti-N-methyl-d-aspartate receptor encephalitis (NMDARE) patients develop refractory disease with prolonged neurological deficits. We aim to evaluate the efficacy of B cell depletion therapy (BCDT) via CD20 an...