Hypoactivity of the prelimbic cortex projecting to the lateral entorhinal cortex contributes to neuropathic pain-induced object recognition memory impairment in mice [0.03%]
腹侧海马脑区投射的前扣带回低活化参与了神经病理性疼痛介导的小鼠认错模型记忆损伤作用
Siyi Han,Zhuang Liu,Jun Fang et al.
Siyi Han et al.
Memory impairment is a common comorbidity of chronic pain that significantly compromises patients' quality of life, yet the underlying neuronal circuit mechanisms remain poorly understood. Here, we employed a spared nerve injury (SNI) mouse...
Single-dose psilocybin promotes cell-type-specific changes of neurons in the orbitofrontal cortex [0.03%]
单剂量致幻剂裸盖菇素可引发顶内皮层神经元类型特异性变化
Ziran Huang,Xiaoyan Wei,Yihui Wang et al.
Ziran Huang et al.
Recent clinical breakthroughs hold great promise for the application of psilocybin in the treatments of psychological disorders, such as depression, addiction, and obsessive-compulsive disorder. Psilocybin is a psychedelic whose metabolite,...
Nabiximols improves sleep architecture in multiple sclerosis: A prospective polysomnographic study [0.03%]
纳比西莫尔斯改善多发性硬化患者的睡眠结构：一项前瞻性脑电图研究
Francesco Fortunato,Adriana Saraceno,Stefania Barone et al.
Francesco Fortunato et al.
We aim to evaluate sleep disruption in people with multiple sclerosis (MS) compared to an age- and gender-matched control cohort using patient-reported outcome measures and formal polysomnography (PSG) scoring, and testing the effect of Nab...
Double-blind, sham-controlled, pilot study of trigeminal nerve stimulation for autism spectrum disorder [0.03%]
针对自闭症谱系障碍的三叉神经刺激治疗的双盲、伪刺激对照试点研究
Jae Hyun Han,Ye Rim Kim,Yoojeong Lee et al.
Jae Hyun Han et al.
Trigeminal nerve stimulation (TNS) is a minimal-risk, noninvasive neuromodulation method with growing evidence of efficacy across psychiatric conditions. However, its safety and potential effects in autism spectrum disorder (ASD) remain und...
Heterogeneous response to efgartigimod in real-world experience with myasthenia gravis: Predictors and treatment strategies [0.03%]
异丙酚替gartigimod治疗重症肌无力的现实世界中的异质性反应：预测因素和治疗策略
Lior Fuchs,Ifat Vigiser,Hadar Kolb et al.
Lior Fuchs et al.
Efgartigimod is an established therapy for acetylcholine receptor antibody-positive generalized myasthenia gravis, yet real-world data on long-term overall responsiveness, response patterns, steroid-sparing effects, bridging therapy use, an...
Metaplasticity in swallowing system via cross-modal neurostimulation: A randomized crossover trial with magnetoencephalography [0.03%]
多模态神经刺激诱发吞咽系统的元塑性现象：一项随机交叉试验及脑磁图研究
Ivy Cheng,Anne Jung,Bendix Labeit et al.
Ivy Cheng et al.
The response to neurostimulation can be modulated based on the state of neural network activation prior to stimulation, a mechanism termed metaplasticity. In the swallowing system, preconditioning the pharyngeal motor cortex with non-invasi...
Home-based transcutaneous auricular vagus nerve stimulation (taVNS) improves motor and non-motor symptoms by improving autonomic and brain functions in patients with Parkinson's disease: A randomized clinical trial [0.03%]
家庭经皮耳迷走神经刺激改善帕金森病自主和脑功能以及运动和非运动症状：一项随机临床试验
Rui Wang,Miaomiao Liu,Quanyuan Liu et al.
Rui Wang et al.
Home-based transcutaneous auricular vagus nerve stimulation (taVNS) holds therapeutic potential for neurological disorders, yet its application in Parkinson's disease (PD) remains underexplored. In this single-blinded, placebo-controlled ra...
Overlapping pathways of migraine and the endocannabinoid system: Potential therapeutic targets [0.03%]
偏头痛和内源大麻素通路的交叉点：潜在的治疗途径
Adriana Della Pietra,Andrew F Russo
Adriana Della Pietra
Migraine is a disabling neurovascular disorder with limited therapeutic options, especially for patients unresponsive to current treatments targeting calcitonin gene-related peptide (CGRP) signaling. The endocannabinoid system (ECS) has eme...
Small molecule JRMS modulating importin-β1 chaperone activity as a therapeutic strategy reducing TDP-43 pathology [0.03%]
小分子JRMS通过调节进口蛋白-β1分子伴侣活性降低TDP-43病理的治疗策略
Marc Shenouda,Sandra Shenouda,Bryan Kartono et al.
Marc Shenouda et al.
Neuronal cytoplasmic aggregation and nuclear depletion of the TAR DNA-binding protein 43 (TDP-43) is the most characteristic pathology of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), causing toxicity through cytopl...
Targeting pathogenic Th17.1 cells via JAK-STAT3 pathway: A novel approach with tofacitinib for refractory myasthenia gravis [0.03%]
JAK-STAT3信号通路靶向病理性Th17.1细胞：托法替布治疗难治性重症肌无力的新策略
Rui Zhao,Chong Yan,Huahua Zhong et al.
Rui Zhao et al.
There remains a critical unmet need for effective, accessible, and well-tolerated therapies for myasthenia gravis (MG) who are refractory to current immunotherapies. The janus kinase and signal transducer and activator of transcription (JAK...