Heterogeneous Deep Gray Matter Iron Deposition Patterns across Multiple Sclerosis Subgroups Defined by the Clinico-Radiological Paradox [0.03%]
多发性硬化次型（定义为临床影像学悖论）的异质深灰质铁沉积模式
Jinlin Jiao,Ruisi Gong,Hao Zhang et al.
Jinlin Jiao et al.
The clinico-radiological paradox in multiple sclerosis (MS) describes the disconnect between white matter lesion load and clinical disability. This study investigated the role of deep gray matter (DGM) iron deposition in this paradox, speci...
Glenn J Treisman,Joyce E King
Glenn J Treisman
Psychiatric disorders have been shown to be risk factors for infection with HIV but have also been shown to be consequences of HIV infection, as well as barriers to effective care. Psychiatric disorders are associated with poor treatment ou...
Neuron-glioma synaptic transmission amplified by free 19S proteasome-mediated AMPAR deubiquitination promotes tumor progression [0.03%]
神经元-胶质瘤突触传递通过自由19S蛋白酶体介导的AMPAR去泛素化促进肿瘤进展
Yijun Lu,Xinyu Liu,Kaiwei Wang et al.
Yijun Lu et al.
Glioma progression is closely linked to neuronal activity. Glutamatergic neurons form functional synapses with glioma cells (neuron-glioma synapses, NGS), directly promoting tumor growth via electrophysiological signaling. However, the key ...
Revisiting elevated HDL cholesterol, cerebral hemodynamic improvement in asymptomatic carotid artery disease: A longitudinal 15O-Gas PET study [0.03%]
高HDL胆固醇与无症状颈动脉疾病患者的脑血流动力学改善：一项纵向15O-Gas PET研究
Yorito Hattori,Soichro Abe,Yoshinori Kakino et al.
Yorito Hattori et al.
Interventional trials with high-density lipoprotein cholesterol (HDL-C)-raising drugs have generally failed to demonstrate a beneficial effect on cardiovascular outcomes, although low HDL-C levels confer the risk of cerebrocardiovascular di...
Targeting dual specificity tyrosine-phosphorylation-regulated kinase 1A mitigates tauopathy and enhances recovery after repetitive head injury [0.03%]
靶向双重特异性酪氨酸磷酸化调节的激酶1A可缓解tau蛋白病变并改善重复性脑损伤后的恢复效果
Benoit Melchior,Mackenzie Browning,Robyn McCartan et al.
Benoit Melchior et al.
Chronic neuroinflammation and accumulation of phosphorylated Tau (pTau) are hallmark features of several neurodegenerative diseases and are also observed in some individuals who have sustained traumatic brain injury (TBI). Notably, more tha...
Parkin protects against traumatic brain injury through regulating mitochondrial quality control [0.03%]
帕金通过调节线粒体质量控制来抵抗脑损伤
Xiuquan Wu,Weihao Lv,Hongqing Chen et al.
Xiuquan Wu et al.
Traumatic brain injury (TBI) is a critical neurological condition, with neuronal damage being its fundamental pathological basis. However, molecular targets for the prevention and treatment of neuronal injury remain to be further explored. ...
Microglial GM3 accumulation impairs Aβ phagocytic activity and promotes neuroinflammation in Alzheimer's disease [0.03%]
阿尔茨海默病中巨噬细胞GM3累积削弱Aβ吞噬作用并促进神经炎症
Se Eun Park,Yun Jae Cha,Young-Kwang Kim et al.
Se Eun Park et al.
Growing evidence underscores the critical role of lipid metabolism in the pathogenesis of Alzheimer's disease (AD). We previously demonstrated that 5xFAD mice exhibit a marked accumulation of ganglioside GM3 in the cerebral cortex and hippo...
Otilia Gliga,Albert Feliu-Soler,Marta Vila-Pueyo
Otilia Gliga
Migraine is a highly prevalent and severe neurological condition characterized by disabling headache attacks accompanied by other neurological symptoms. Its pathophysiology involves activation of the trigeminovascular system, cortical sprea...
Steven M Paul,Samantha E Yohn
Steven M Paul
Schizophrenia is a chronic, disabling and potentially fatal psychiatric syndrome characterized by three primary symptom domains: positive, negative, and cognitive symptoms, for which current dopamine D2 receptor antagonists provide only par...
Transcranial direct current stimulation is safe and feasible in hyperacute ischemic stroke (DICAST-SF trial) [0.03%]
经颅直流电刺激在超急性缺血性脑卒中患者中的安全性及可行性研究(DICAST-SF试验)
Matej Slovak,David Kemlink,Pavel Dusek et al.
Matej Slovak et al.
Cathodal transcranial direct current stimulation (C-tDCS) is a potential neuroprotective method in the hyperacute phase of ischemic stroke. We aimed to assess safety, tolerability, feasibility, and potential efficacy of C-tDCS in stroke pat...