Noninvasive Neuroprosthesis Promotes Cardiovascular Recovery After Spinal Cord Injury [0.03%]
非侵入性神经假体可促进脊髓损伤后的心血管恢复
Rahul Sachdeva,Tom E Nightingale,Kiran Pawar et al.
Rahul Sachdeva et al.
Spinal cord injury (SCI) leads to severe impairment in cardiovascular control, commonly manifested as a rapid, uncontrolled rise in blood pressure triggered by peripheral stimuli-a condition called autonomic dysreflexia. The objective was t...
Correction to: The PDE10A Inhibitor TAK-063 Reverses Sound-Evoked EEG Abnormalities in a Mouse Model of Fragile X Syndrome [0.03%]
Correction to: PDE10A抑制剂TAK-063逆转了Fragile X综合征小鼠模型的声音诱发的脑电图异常
Carrie R Jonak,Manbir S Sandhu,Samantha A Assad et al.
Carrie R Jonak et al.
Ferulic Acid Ameliorates Alzheimer's Disease-like Pathology and Repairs Cognitive Decline by Preventing Capillary Hypofunction in APP/PS1 Mice [0.03%]
金丝桃苷通过改善脑小血管功能防治阿尔茨海默病样病理和认知障碍
Ni-Ya Wang,Jin-Nan Li,Wei-Lin Liu et al.
Ni-Ya Wang et al.
Brain capillaries are crucial for cognitive functions by supplying oxygen and other nutrients to and removing metabolic wastes from the brain. Recent studies have demonstrated that constriction of brain capillaries is triggered by beta-amyl...
Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington's Disease: Preclinical Evidence with the p75NTR Ligand LM11A-31 [0.03%]
亨廷顿舞蹈病的治疗反应的神经影像学、尿液和血浆生物标志物：p75NTR配体LM11A-31的前临床证据
Danielle A Simmons,Brian D Mills,Robert R Butler Iii et al.
Danielle A Simmons et al.
Huntington's disease (HD) is caused by an expansion of the CAG repeat in the huntingtin gene leading to preferential neurodegeneration of the striatum. Disease-modifying treatments are not yet available to HD patients and their development ...
Specific Expression of Glial-Derived Neurotrophic Factor in Muscles as Gene Therapy Strategy for Amyotrophic Lateral Sclerosis [0.03%]
以肌肉特异性表达神经营养因子治疗肌萎缩侧索硬化症的研究进展
Guillem Mòdol-Caballero,Belén García-Lareu,Mireia Herrando-Grabulosa et al.
Guillem Mòdol-Caballero et al.
Glial cell line-derived neurotrophic factor (GDNF) is a powerful neuroprotective growth factor. However, systemic or intrathecal administration of GDNF is associated with side effects. Here, we aimed to avoid this by restricting the transge...
Targeting TDP-43 Pathology Alleviates Cognitive and Motor Deficits Caused by Chronic Cerebral Hypoperfusion [0.03%]
靶向TDP-43病理学可减轻慢性脑低灌注引起的认知和运动功能障碍
Sai Sampath Thammisetty,Laurence Renaud,Vincent Picher-Martel et al.
Sai Sampath Thammisetty et al.
Vascular dementia is one of the most common forms of dementia in aging population. However, the molecular mechanisms involved in development of disease and the link between the cerebrovascular pathology and the cognitive impairments remain ...
Sleep and Epilepsy: a Focused Review of Pathophysiology, Clinical Syndromes, Co-morbidities, and Therapy [0.03%]
睡眠与癫痫：病理生理、临床综合征、共病及治疗的综述性研究
J Layne Moore,Diego Z Carvalho,Erik K St Louis et al.
J Layne Moore et al.
A healthy brain requires balancing of waking and sleeping states. The normal changes in waking and sleeping states result in neurophysiological conditions that either increase or decrease the tendency of seizures and interictal discharges t...
Michelle F Devine,Erik K St Louis
Michelle F Devine
Associations between sleep disorders and neurological autoimmunity have been notably expanding recently. Potential immune-mediated etiopathogenesis has been proposed for various sleep disorders including narcolepsy, Kleine-Levin syndrome, a...
Recent Advances in Imaging of Preclinical, Sporadic, and Autosomal Dominant Alzheimer's Disease [0.03%]
临床前期、散发性和常染色体显性阿尔茨海默病的影像学最新进展
Rachel F Buckley
Rachel F Buckley
Observing Alzheimer's disease (AD) pathological changes in vivo with neuroimaging provides invaluable opportunities to understand and predict the course of disease. Neuroimaging AD biomarkers also allow for real-time tracking of disease-mod...
Small Molecule Rescue of ATXN3 Toxicity in C. elegans via TFEB/HLH-30 [0.03%]
小分子通过TFEB/HLH-30救援C. elegans中的ATXN3毒性
Yasmin Fardghassemi,Claudia Maios,J Alex Parker
Yasmin Fardghassemi
Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is a polyglutamine expansion disease arising from a trinucleotide CAG repeat expansion in exon 10 of the gene ATXN3. There are no effective pharmacological tr...