Translational Neurocritical Care Research: Advancing Understanding and Developing Therapeutics [0.03%]
转化神经危重症研究：加深理解与开发治疗手段
J Claude Hemphill rd,Michael L James
J Claude Hemphill rd
Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate [0.03%]
一类比多西拉敏更具有选择性激活中枢神经系统Nrf2的小分子乙烯亚砜咪唑类化合物的特性研究
Karl E Carlström,Praveen K Chinthakindi,Belén Espinosa et al.
Karl E Carlström et al.
The Nrf2 transcription factor is a key regulator of redox reactions and considered the main target for the multiple sclerosis (MS) drug dimethyl fumarate (DMF). However, exploration of additional Nrf2-activating compounds is motivated, sinc...
Autoimmune Encephalitis: NMDA Receptor Encephalitis as an Example of Translational Neuroscience [0.03%]
自身免疫性脑炎：N-甲基-D天冬氨酸受体脑炎的转化神经科学案例研究
Brad J Kolls,Yasmin A O&#x;Keefe,Alok K Sahgal
Brad J Kolls
Autoimmune encephalitis (AE) is a group of disorders causing synaptic receptor dysfunction with a broad range of neurological symptoms that has been historically difficult to differentiate clinically. Today, AE represents an excellent examp...
Targeting Therapeutic Antibodies to the CNS: a Comparative Study of Intrathecal, Intravenous, and Subcutaneous Anti-Nogo A Antibody Treatment after Stroke in Rats [0.03%]
不同给药方式anti-nogo抗体治疗卒中后运动功能缺损的比较研究
Anna-Sophia Wahl,Daphne Correa,Stefan Imobersteg et al.
Anna-Sophia Wahl et al.
Antibody-based therapeutics targeting CNS antigens emerge as promising treatments in neurology. However, access to the CNS is limited by the blood-brain barrier. We examined the effects of a neurite growth-enhancing anti-Nogo A antibody the...
Aurélien Mazeraud,Cássia Righy,Eleonore Bouchereau et al.
Aurélien Mazeraud et al.
Septic-associated encephalopathy (SAE) is a key manifestation of sepsis, ranging from delirium to coma and occurring in up to 70% of patients admitted to the ICU. SAE is associated with higher ICU and hospital mortality, and also with poore...
Cerebellar Astrocyte Transduction as Gene Therapy for Megalencephalic Leukoencephalopathy [0.03%]
小脑星形胶质细胞转导治疗巨脑白质病的基因疗法
Angela Sánchez,Belén García-Lareu,Meritxell Puig et al.
Angela Sánchez et al.
Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare genetic disorder belonging to the group of vacuolating leukodystrophies. It is characterized by megalencephaly, loss of motor functions, epilepsy, and mild mental de...
Ajith J Thomas,Luis Ascanio-Cortez,Santiago Gomez et al.
Ajith J Thomas et al.
Fever can affect the majority of patients with subarachnoid hemorrhage (SAH) and many times no identifiable source is found for the fever whether infectious or sterile, like deep vein thrombosis. We hypothesized that fever in SAH is mediate...
Melika Hosseini,Robert H Wilson,Christian Crouzet et al.
Melika Hosseini et al.
Cardiac arrest (CA) afflicts ~ 550,000 people each year in the USA. A small fraction of CA sufferers survive with a majority of these survivors emerging in a comatose state. Many CA survivors suffer devastating global brain injury with some...
ω-3PUFAs Improve Cognitive Impairments Through Ser133 Phosphorylation of CREB Upregulating BDNF/TrkB Signal in Schizophrenia [0.03%]
ω-3多不饱和脂肪酸通过调节CREB丝氨酸133磷酸化上调BDNF/TrkB信号改善精神分裂症的认知缺陷作用机制研究
Cuiping Guo,Yi Liu,Mao-Sheng Fang et al.
Cuiping Guo et al.
Schizophrenia (SZ) is a serious mental condition and is associated with cognitive impairments. Brain-derived neurotrophic factor (BDNF) is one of the learning- and memory-related molecules found in the CNS and its level was reported to be r...
Correction to: Imaging Guidance for Therapeutic Delivery: the Dawn of Neuroenergetics [0.03%]
对影像引导治疗递送：神经能量学的黎明的更正
Vilakshan Alambyan,Jonathan Pace,Persen Sukpornchairak et al.
Vilakshan Alambyan et al.