Aberrant S-nitrosylation in the TCA cycle contributes to mitochondrial dysfunction, energy compromise, and synapse loss in neurodegenerative diseases [0.03%]
三羧酸循环中的异常S-硝基化导致神经退行性疾病中的线粒体功能障碍、能量耗竭和突触丧失
Tomohiro Nakamura,Anamika Sharma,Stuart A Lipton
Tomohiro Nakamura
Neuronal synaptic activity relies heavily on mitochondrial energy production, as synaptic transmission requires substantial ATP. Accordingly, mitochondrial dysfunction represents a key underlying factor in synaptic loss that strongly correl...
The role of gasotransmitters in Parkinson's disease: Interplay of nitric oxide, carbon monoxide, and hydrogen sulfide [0.03%]
气体信号分子在帕金森病中的作用：一氧化氮、一氧化碳和硫化氢的相互作用
Jennifer L O&#x;Connor,Dionisia M Fountos,Bita Firouzan et al.
Jennifer L O&#x;Connor et al.
Parkinson's disease (PD) is a progressive neurodegenerative condition marked by dopaminergic neuron loss and α-synuclein accumulation. In recent years, a growing body of work has explored the roles of endogenous gasotransmitters-namely nit...
Redox modulation of the complement cascade contributes to synapse loss in Alzheimer's disease [0.03%]
红氧调节补体级联反应导致阿尔茨海默病中突触丢失
Chang-Ki Oh,Yubo Wang,Stuart A Lipton
Chang-Ki Oh
Neuroinflammation is characterized by activation of the immune response in the central nervous system (CNS). In Alzheimer's disease (AD), this involves stimulation of glial cells, including microglia and astrocytes, that surround senile pla...
Jordi Gascón-Bayarri,Inmaculada Rico,Cristina Sánchez-Castañeda et al.
Jordi Gascón-Bayarri et al.
Introduction: In search of disease-modifying treatments for the Niemann-Pick disease type C (NPC), this Phase II single-arm clinical trial evaluated the safety and efficacy of efavirenz, a reverse transcriptase inhibitor ...
Targeting macro- and micro-nutrient regulation of H2S signaling for the aging brain [0.03%]
靶向硫化氢信号转导的宏/微量营养剂调节以应对衰老大脑带来的挑战
Matthew Godwin,Christopher Hine
Matthew Godwin
Global growth in aged population demographics is a testament to medical and societal innovations over the past 100 years. However, with advanced age comes declines in various organs and tissues, thus limiting quality of life in one's later ...
Patricia K Coyle
Patricia K Coyle
Xiaofei Sun,Yayue Liu,Lucynda Pham et al.
Xiaofei Sun et al.
In recent years, drug-coated balloons (DCB) have been increasingly used for intervention therapy of intracranial atherosclerotic stenosis (ICAS) with significant efficacy. However, the timing of DCB intervention therapy remains controversia...
Martijn Figee,Patricio Riva Posse,Helen Mayberg
Martijn Figee
Integrating perfusion imaging derived venous outflow and tissue-level collateral parameters in a comprehensive clinical model enhances prognostication in large vessel occlusion stroke [0.03%]
基于灌注成像的静脉回流和组织水平侧支参数的综合性临床模型可提高大血管闭塞卒中的预后判断能力
Janet Mei,Hamza Adel Salim,Dhairya A Lakhani et al.
Janet Mei et al.
Arterial inflow restoration and collateral status have been significantly correlated with functional outcomes in AIS-LVO patients undergoing mechanical thrombectomy (MT). CT perfusion imaging biomarkers, including prolonged venous transit (...