The EGR1/ZFP36 axis governs glycosphingolipid metabolic reprogramming in monocyte-derived macrophages in guillain-barré syndrome [0.03%]
EGR1/ZFP36轴调控单核细胞衍生的巨噬细胞中 Guillain-Barré 综合征中的糖神经酰胺代谢重编程
Meng Li,Qiaoming Liu,Weixi Chen et al.
Meng Li et al.
Guillain-Barré syndrome (GBS) is an immune-mediated demyelinating disorder of peripheral nerves with an unclear pathogenesis. This study integrated GBS clinical single-cell data with EAN model transcriptome data, establishing in vivo and i...
Focussed ultrasound thalamotomy and functional MRI as windows to neural networks underlying essential tremor [0.03%]
聚焦超声丘脑毁损及功能磁共振成像在必要性震颤的神经网络中的作用研究
Stephen Tisch
Stephen Tisch
Continuous intravenous infusion of human mesenchymal stromal cell-derived small extracellular vesicles in spinal cord injured rat modulates extracellular matrix and has greater therapeutic efficacy than multiple single injections [0.03%]
人源间充质基质细胞衍生的小细胞外囊泡的连续输注比单次多点注射在脊髓损伤中的治疗效果更佳
Masahito Nakazaki,Karen L Lankford,Masayuki Toyoshima et al.
Masahito Nakazaki et al.
Intravenous (IV) administration of human bone marrow mesenchymal stromal/stem cell-derived small extracellular vesicles (hMSC-sEVs) improves motor recovery in spinal cord-injured rats. We previously observed that daily IV injections over th...
Environmental pollutants and autism spectrum disorder: Effects of plasticizers on core phenotypes and molecular targets [0.03%]
环境污染物和自闭症谱系障碍：塑化剂对核心表型和分子靶点的影响
Yao Sun,Liang Lyu,Xirui Zhang et al.
Yao Sun et al.
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder shaped by genetic and environmental factors. Phthalates, widely used as plasticizers in consumer products, have gained attention as potential environmental contributors...
Combining transcranial electrical stimulation with training in older adults: Effects on dual-task ability [0.03%]
经颅电刺激与老年人训练结合对改善双重任务能力的影响
Yong Jiang,Azadeh Lesani,Xue Guo et al.
Yong Jiang et al.
Background: Enhancing dual-task (DT) performance in older adults through cognitive improvement may help prevent neurodegenerative decline. Objective: ...
No association between the wearing-off effect and α4-integrin receptor saturation in natalizumab treated patients with relapsing-remitting multiple sclerosis [0.03%]
那他珠单抗治疗复发缓解型多发性硬化症患者中无 wearing-off 效应与α4整合素受体饱和度相关性的研究
Sean A Freeman,Celso Rual,Damien Biotti et al.
Sean A Freeman et al.
Approximately half of patients with relapsing-remitting multiple sclerosis treated with natalizumab (NTZ) report transient symptom worsening - particularly fatigue - toward the end of the dosing interval. This phenomenon, commonly referred ...
Responsive neurostimulation in children, adolescents, and young Adults-Longitudinal effectiveness and safety [0.03%]
儿童、青少年和年轻成人响应性神经刺激的纵向有效性和安全性
Steven T Lee,Shital Patel,Cemal Karakas et al.
Steven T Lee et al.
Drug-resistant epilepsy (DRE) remains challenging to treat, and seizure control often fluctuates over time. Responsive neurostimulation (RNS) is increasingly used in pediatric and young adult populations, yet long-term effectiveness and saf...
A compound pulsed magnetic field achieves superior cognitive benefits against Alzheimer's disease progression via multi-level restoration of neural oscillations and cerebral perfusion [0.03%]
复合脉冲磁场通过多级恢复神经振荡和脑血流实现优于阿尔茨海默病进程的认知效益
Xue Wang,Xuting Wang,Haoyu Zhao et al.
Xue Wang et al.
The link between impaired gamma oscillations and Alzheimer's disease (AD) has inspired therapies using rhythmic physical stimuli. However, given that cognition requires cross-frequency interactions like theta-gamma coupling, single-frequenc...
When gene replacement becomes a double-edged sword: Guardrails for precision neurotherapeutics in Lafora disease [0.03%]
基因替代的双刃剑效应——拉福拉病精准神经治疗的对策与建议
Antonella Riva,Pasquale Striano
Antonella Riva
Ivana Dabaj,Thi Hai Yen Nguyen,Emmanuelle Lagrue et al.
Ivana Dabaj et al.
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder caused by SMN1 gene variants, leading to the degeneration of anterior horn cells in the spinal cord. It is a disabling disease with varying severity. Nusinersen,...