Assessing the trustworthiness of health guidelines recommendations: the Transparent, Rigorous, Usable, Standardised and Trustworthy Guide (TRUSTGUIDES) tools development [0.03%]
评估健康指南建议的可信度：开发透明、严谨、实用、标准化和可信赖的指南工具（TRUSTGUIDES）
Chiara Arienti,Ignacio Neumann,Elie A Akl et al.
Chiara Arienti et al.
Background: Health guidelines play a central role in informing clinical practice, public health measures and health policy. But their trustworthiness may be undermined by factors such as insufficient methodological rigour...
Frameworks to identify research gaps, frame research needs, and derive research priorities from evidence syntheses: a scoping review [0.03%]
识别研究差距、确定研究需求和从证据综合中得出研究优先级的框架：一项题录综述
Omar Dewidar,Mouad Elganga,Martin Ringsten et al.
Omar Dewidar et al.
Objective: To identify and describe frameworks for systematically identifying research gaps from evidence syntheses, framing research needs, and establishing priorities, with emphasis on their use of GRADE certainty of ev...
Active placebo control interventions in pharmacological trials: a scoping review of the development process and a terminological analysis [0.03%]
药物试验中活性安慰剂控制干预的开发过程及术语分析的综述性研究
David Ruben Teindl Laursen,Josefina Salazar,Gesche Jürgens et al.
David Ruben Teindl Laursen et al.
Objectives: Randomised trials with active placebo control groups rarely report details about the development process of the active placebo control intervention, and the terminology is inconsistent. We therefore wanted 1) ...
Integrating evidence from randomised trials and prospective observational studies: an application of GRADE guidance 44 to nutrition evidence syntheses [0.03%]
GRADE指导44在营养证据综合中同时应用随机试验和前瞻性观察性研究的证据
Julia Stadelmaier,Gina Bantle,Carlos A Cuello-Garcia et al.
Julia Stadelmaier et al.
Objective: The GRADE Working Group recently published guidance on integrating evidence from randomised (RCTs) and non-randomised studies of interventions in systematic reviews. Our study aims to explore the application of...
Exclusion by Design: Enrollment Criteria Limit Older Adult Participation in SARS-CoV-2 Vaccine Clinical Trials [0.03%]
设计的排斥：入组标准限制了老年人在SARS-CoV-2疫苗临床试验中的参与度
Taylor N Johnson,Helen Y Chu,Alison E Fohner
Taylor N Johnson
Background and objectives: Older adults (≥65 years) face a disproportionate burden of COVID-19 mortality yet remain underrepresented in clinical trials despite this group accounting for 76% of COVID-19 deaths. Hundreds o...
What US Medical Students Need to Learn About Clinical Practice Guidelines: A Qualitative Study of US Students and a Global Subset of Guidelines Developers [0.03%]
美国医学生需要了解的临床实践指南内容：一项关于美国医学生和部分全球临床实践指南制定者的质性研究
Michael D Yi,Victoria Shi,Rachel E Christensen et al.
Michael D Yi et al.
Background: Undergraduate United States (US) medical education may not provide adequate education on clinical practice guidelines (CPGs). Objectives: ...
Changes in estimands and prevalence of discrepancies in conclusions under the two-trial paradigm: a systematic review [0.03%]
两项试验方案下估计量的变化及其结论不一致的系统评价
Alex Hlavaty,Clément Jambon-Barbara,Marc Manceau et al.
Alex Hlavaty et al.
Background and objective: The U.S. Food and Drug Administration (FDA) has recommended that two adequate and well-controlled trials are conducted to establish efficacy. Although replication strengthens evidentiary robustne...
External Validation of Dementia Risk Models in a UK Population-Based Prospective Cohort Amongst Stroke Survivors [0.03%]
基于英国卒中生存者的前瞻性队列对痴呆风险模型进行外部验证
Jacob Brain,Ruth H Jack,Blossom Christa Maree Stephan et al.
Jacob Brain et al.
Objectives: Stroke-survivors are at a significantly elevated risk of post-stroke cognitive impairment and dementia, yet early identification of high-risk cases remains a challenge. Dementia risk models developed for the g...
Limited Representation of Authors from Low- and Middle-Income Countries (LMICs) in Trials with Participants from LMICs Across 15 Years (2008-2023) [0.03%]
低收入和中等收入国家作者在以这些国家参与者为对象的试验中的代表性不足（2008-2023年）
Harleen K Marwah,Abarna Pearl,Christos P Kotanidis et al.
Harleen K Marwah et al.
Background: Trials increasingly include participants from low- and middle- income countries (LMICs), but representation of investigators from these countries among trial authors may not be proportional. We determined rece...
Evaluating the Integration of the Reported Treatment Mechanisms and Goal of Treatment in Randomized Controlled Trials for Low Back Pain: Protocol for a Meta-Epidemiological Analysis [0.03%]
评估随机对照试验中报道的治疗方法机制和治疗目标整合情况：一项针对下背痛的 meta-流行病学分析方案
Renske Versloot,Annemarie de Zoete,Jan Pool et al.
Renske Versloot et al.
Objective: Treatment mechanisms for Exercise, Cognitive Behavioural Therapy (CBT) and Spinal Manipulative Therapy (SMT) are broadly theorised and examined in basic science studies, however they are not typically incorpora...