Beyond pen and paper: Simulation as a transformative training ground for guideline methodologists [0.03%]
超越纸笔：模拟作为指南制定者的变革性培训场所
Michael McCaul,Simone Titus-Dawson
Michael McCaul
Objective: Simulation of guideline panel meetings has been used to increase panelists knowledge and familiarity with the process. However, a gap remains in understanding how this pedagogical design strengthens capabilitie...
Data sharing policies, requirements, and support from public and private clinical trial sponsors: a survey on top sponsors of clinical trials in Europe [0.03%]
欧洲主要临床试验资助者关于公共和私营临床试验发起方的数据共享政策、要求和支持的调查
Ka Hin Tai,Giulia Varvarà,Emma Escoffier et al.
Ka Hin Tai et al.
Objective: To map the presence, public availability, and content of clinical trial data sharing policies, data management and sharing plans, and data use agreements among the most prolific public and private clinical tria...
Development and Internal Validation of a Clinical Risk Score for Loss to Follow-Up Among Drug-Resistant Tuberculosis Patients in a High-Burden Setting, Ethiopia: A Multicenter Retrospective Study [0.03%]
在高负担环境下针对耐药结核病患者失访的临床风险评分的发展与内部验证：多中心回顾性研究
Tilahun Nega Godana,Fantahun Ayenew Mekonnen,Nebiyu Mekonnen Derseh
Tilahun Nega Godana
Introduction: Loss to follow-up (LTFU) in drug-resistant tuberculosis (DR-TB) treatment is a major global public health problem, leading to continued transmission, further amplification of drug resistance, and increased m...
Usability and relevance of specialized population-based cancer registry data in externally controlled trials [0.03%]
基于人口的专科癌症登记数据在外对照试验中的适用性和相关性
Valérie Jooste,Anne-Marie Bouvier,Côme Lepage et al.
Valérie Jooste et al.
Background: Randomized clinical trials are becoming very challenging to perform in oncology both in rare cancers and in more common cancers, fragmented according to molecular characteristics. ...
SINGLE REVIEWER ASSESSMENTS OF CERTAINTY OF EVIDENCE IN NETWORK META-ANALYSES PROBABLY DO NOT MISLEAD DECISION-MAKERS: A CASE STUDY [0.03%]
单个评价人对网状Meta分析证据确实性的评估可能不会误导决策者：一项案例研究
Carlos Zaror,Róbinson Chávez-Concha,Ariel Izcovich et al.
Carlos Zaror et al.
Background: Systematic reviews with network meta-analyses (NMA) are the most comprehensive form of evidence synthesis for informing evidence-based practice recommendations. Rating the certainty of evidence (CoE) is a cruc...
Dietary exposure-outcome associations do not systematically differ by risk of bias in observational studies: A meta-epidemiological study [0.03%]
暴露关联在观察性研究中并不系统地因偏倚风险而不同：一项元流行病学研究
Julia Stadelmaier,Gina Bantle,Maria Petropoulou et al.
Julia Stadelmaier et al.
Objective: To investigate the influence of bias from methodological characteristics on exposure-outcome associations in nutrition observational studies using the ROBINS-E tool. ...
Incomplete Reporting Persists in Orthopedic Machine Learning Models: A Systematic Review of TRIPOD and TRIPOD+AI Reporting Completeness [0.03%]
骨科机器学习模型的报告不完整持续存在：系统回顾TRIPOD和TRIPOD+AI报告完整性
R Harmen Kuijten,Tom M de Groot,Maarten A van Weezenbeek et al.
R Harmen Kuijten et al.
Background and objective: Machine learning (ML) prognostic models in orthopedic surgery are published at an accelerating pace, yet whether reporting meets TRIPOD+AI (2024) transparency standards remains unclear. We examin...
A Novel Multi-Stream Triangulation Method to Define Decision Thresholds for Clinical Practice Guidelines A Canadian Association of Gastroenterology Consensus Report [0.03%]
一种定义临床实践指南决策阈值的新型多流三角测量方法：加拿大胃肠病学协会共识报告
Frances Tse,Nauzer Forbes,Harminder Singh et al.
Frances Tse et al.
Background: Within the GRADE Evidence-to-Decision (EtD) framework, guideline panels must judge the magnitude of health effects (trivial, small, moderate, large). Current implicit judgments are subjective and susceptible t...
Estimating Overall Survival Treatment Effects in Oncology Trials: Hazard Ratio Instability and RMST as a Robust, Internally Predictive Complement [0.03%]
肿瘤试验中估计总生存期治疗效应：HR的不稳定性以及作为稳健且可预测的补充的RMST
Mingye Zhao,Taihang Shao,Hanqiao Shao et al.
Mingye Zhao et al.
Objective: Overall survival (OS) is the definitive endpoint in oncology randomized controlled trials (RCTs), yet OS is often immature at interim analyses. Hazard ratio (HR) remains the dominant OS effect measure, but it d...
Flash Mob Research: An Emerging Paradigm for Rapid and Participatory Clinical Investigation [0.03%]
“快闪族”研究：迅速而具有参与性的临床调查的新模式
Murali Krishna Moka,Jessica Vanathi M,Deepalaxmi Rathakrishnan et al.
Murali Krishna Moka et al.
Objective: To highlight the emerging role of Flash Mob Research (FMR) as an innovative, rapid, collaborative, and participatory methodology for conducting clinical research, and to discuss its potential applications, adva...