The importance of adequate user feedback for developing appraisal tools for evidence synthesis - the case of TACIT (Tool for Addressing Conflicts of Interest in Trials) [0.03%]
用户反馈在证据综合评价工具开发中的重要性——以试验利益冲突处理工具(TACIT)为例
Andreas Lundh,Isabelle Boutron,Lesley A Stewart et al.
Andreas Lundh et al.
Background: The validity of randomised trials included in evidence syntheses is typically assessed using appraisal tools. Such tools are often developed by a group of experts and usually involve some feedback from intende...
Bivariate analysis of symptom and medication score effect sizes in grass pollen allergen immunotherapy reveals route-dependent dissociation: implications for the combined symptom and medication score [0.03%]
基于草花粉过敏免疫治疗的双变量症状和药物评分效应分析显示给药途径依赖性差异：对联合症状和用药评分的影响
Gabriele Di Lorenzo,Marcello Melluso
Gabriele Di Lorenzo
Background: The Combined Symptom and Medication Score (CSMS) has been recommended as the primary endpoint in allergen immunotherapy (AIT) trials, resting on the assumption that symptom scores (SS) and medication scores (M...
The DECISION Study: Protocol for the Development and Internal Validation of a Multimodal Decision-Making Capacity Framework [0.03%]
决策研究：多模式决策能力框架的发展和内部验证的协议
Carolin I Kurz,Paulina Tegethoff,Johanna Gelz et al.
Carolin I Kurz et al.
Background: Decision-making capacity (DMC) is a prerequisite for valid informed consent, as well as being a key methodological requirement in clinical and epidemiological research. For individuals with neurocognitive diso...
Ali Al-Kassab-Córdova,Stephen Burgess,Nasir Bashir
Ali Al-Kassab-Córdova
The growing use of the term "real-world evidence" (RWE) has introduced a classification of clinical research based on its perceived proximity to routine practice rather than its methodological characteristics. Although the term is often use...
Externally anchored covariate completion improved target-population effect estimation in meta-analysis with incomplete aggregate data: a simulation study [0.03%]
基于外部工具变量的协变量补全改善了 Meta 分析中目标总体效应估计：一项模拟研究
Lingyao Sun,Mingye Zhao,Dachuang Zhou et al.
Lingyao Sun et al.
Objective: To develop and evaluate Externally Anchored Covariate Completion for Meta-analysis (EACC-Meta), a framework that enables target-population treatment effect estimation from incomplete aggregate data by borrowing...
AI-enabled GRADE: How the GRADE Working Group will use automation to rate the certainty of evidence of intervention effects [0.03%]
基于人工智能的 GRADE：分级工作组如何利用自动化评估干预措施效果证据的确性的质量分级
Bernardo Sousa-Pinto,Manuel Marques-Cruz,Rafael José Vieira et al.
Bernardo Sousa-Pinto et al.
Objective: The Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group is developing GRADErater (GRADE Rating Automation Through Enhanced Reasoning), an official, automated tool for evaluat...
Harms Reporting Was Frequently Incomplete or Discordant in Biomedical Randomized Trials Published in 2023: A Meta-epidemiological Study [0.03%]
2023年生物医学随机试验中伤害报告经常不完整或矛盾：一项元流行病学研究
Daniel Shaughnessy,Ashma Krishan,Kevin Naaman et al.
Daniel Shaughnessy et al.
Objective: To characterize harms specification, harms reporting, concordance between specified and reported harms, transparency about harms reporting criteria, and equity-related harms reporting in randomized controlled t...
Using an Open Science Checklist in Grant Proposal Reviews to Predict Reproducibility of Funded Publications [0.03%]
利用开放科学检查表预测资助出版物的可重复性
Ayu Putu Madri Dewi,Anne Floor Holtrop,Nicholas J DeVito et al.
Ayu Putu Madri Dewi et al.
Objective: To determine whether an open science checklist can be useful for predicting the reproducibility of publications resulting from these grant proposals when used by grant referees assessing them. ...
A comparison of five statistical methods used to analyse longitudinal EORTC QLQ-C30 quality of life scores in randomised controlled trials: a simulation study [0.03%]
用于分析随机对照试验中纵向EORTC QLQ-C30生活质量评分的五种统计方法的比较：一项模拟研究
Rosie A Harris,Jessica Harris,Eric Lim et al.
Rosie A Harris et al.
Background: Quality of life (QoL) is an important component of cancer care. The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) is widely used to evaluate p...
Iztok Hozo,Lars G Hemkens,Benjamin Djulbegovic
Iztok Hozo
Objective: To develop a decision-analytic (DA) method for sample size determination in pragmatic randomized trials (RCTs) aimed at selecting the better treatment. The method is anchored to the stakeholder-defined minimall...