Randomized trials of 'personalized', 'individualized' and 'precision' interventions are very diverse and have low transparency and high bias [0.03%]
随机试验中“个性化”、“个体化”和“精准”干预措施具有多样化、低透明度和高偏差的特点
Luigi Russo,Nicolò Lentini,Luisa Soru et al.
Luigi Russo et al.
Background and objective: The terms 'personalized', individualized' and 'precision' are increasingly used to describe interventions, yet their operational meaning is often unclear. Despite extensive conceptual debate, no ...
Ulrich Mansmann
Ulrich Mansmann
Realizing the Full Potential of Registry-Based Randomized Controlled Trials [0.03%]
挖掘基于注册表的随机对照试验的潜力
Anna B C Humphreys,Bertil Lindahl,Camila Olarte Parra
Anna B C Humphreys
Context: Advantages of registry-based randomized controlled trials (RRCTs) include their relatively low-cost and ability to recruit many individuals. Notably, the registry infrastructure captures data on all individuals, ...
The Challenge of Recruitment in Clinical Trials in Canada: an analysis of trial registry data [0.03%]
加拿大临床试验招募的挑战：对试验注册数据的分析
Alexander C T Tam,Jack Smith,Mark J Harrison et al.
Alexander C T Tam et al.
Background: Clinical trials that have low enrolment risk being underpowered for answering the intended research question and wasting the resources invested. We aimed to quantify the extent of unsuccessful recruitment amon...
A call for methodological guidance to support initiatives to develop diagnostic criteria for conditions without reference standard diagnostic tests [0.03%]
呼吁提供方法学指导以支持制定缺乏参考标准诊断试验的疾病的诊断标准的倡议
Samuel J White,Timothy H Barker,Tracy Merlin et al.
Samuel J White et al.
Implementation of the GRADE Adolopment framework was perceived as appropriate, acceptable, and feasible in a national guideline program in the Philippines: a mixed-methods study [0.03%]
在菲律宾国家指南计划中实施分级采纳框架被认为适当、可接受和可行：一项混合方法研究
G Cabaluna Ian Theodore,L Biños Katrice,Zamora Rosally et al.
G Cabaluna Ian Theodore et al.
Objectives: The GRADE Adolopment framework provides a structured approach for adapting and developing clinical practice guidelines; however, evidence on its implementation in low- and middle-income countries is limited. T...
Using large language models for automated assessment of reporting quality and completeness of prediction model studies [0.03%]
使用大型语言模型自动评估预测模型研究的报告质量和完整性
I Spiero,A M Leeuwenberg,J Kamperman et al.
I Spiero et al.
Background and objective: Transparent and complete reporting in scientific papers is important for interpretation of study results and for downstream evidence generation such as systematic reviews and clinical guidelines....
The Win Ratio in Contemporary Clinical Trials: Growing Adoption and Interpretation Challenges - A Meta-epidemiological Study [0.03%]
当代临床试验中胜率的增用及解释挑战——一项元流行病学研究
Qize Li,Yingxuan Zhu,Yanyan Zhao et al.
Qize Li et al.
Objectives: The win ratio (WR) has been used with increasing frequency in clinical trials with hierarchical composite endpoints. This meta-epidemiological study aims to systematically evaluate the contemporary use of the ...
Jakub Furmaga,Samuel McDonald,Bhaskar Thakur et al.
Jakub Furmaga et al.
Enhancing reporting of process evaluations in healthcare: A preliminary Checklist for RepOrting Process evaluations (CROP), a Delphi study [0.03%]
医疗保健中过程评价的报告增强：一种关于过程评价报告（CROP）的初步清单，德尔菲研究
Lisa Cruycke,Yoeri Swalens,Liesel Cornelis et al.
Lisa Cruycke et al.
Background: Healthcare faces increasing complexity in addressing multimorbidity, integrating social and medical care, and implementing innovative technologies. While complex interventions are increasingly used to address ...