Engineering mesoporous polydopamine-based potentiate STING pathway activation for advanced anti-biofilm therapy [0.03%]
工程化中孔多巴胺基底物以增强STING途径活化用于先进抗菌膜疗法
Shicheng Huo,Zhuocheng Lyu,Xiaoyuan Wang et al.
Shicheng Huo et al.
The biofilm-induced "relatively immune-compromised zone" creates an immunosuppressive microenvironment that is a significant contributor to refractory infections in orthopedic endophytes. Consequently, the manipulation of immune cells to co...
An ultra-long-acting L-asparaginase synergizes with an immune checkpoint inhibitor in starvation-immunotherapy of metastatic solid tumors [0.03%]
一种超长效L-天冬氨酰酶与免疫检查点抑制剂联合应用于转移性实体瘤的饥饿免疫疗法中产生协同作用
Sanke Zhang,Like Gong,Yuanzi Sun et al.
Sanke Zhang et al.
Metastasis stands as the primary contributor to mortality associated with tumors. Chemotherapy and immunotherapy are frequently utilized in the management of metastatic solid tumors. Nevertheless, these therapeutic modalities are linked to ...
Stiff extracellular matrix drives the differentiation of mesenchymal stem cells toward osteogenesis by the multiscale 3D genome reorganization [0.03%]
刚性的细胞外基质通过多尺度的三维基因组重构驱动间充质干细胞向成骨方向分化
Jing Na,Chengzheng Tai,Ziyi Wang et al.
Jing Na et al.
Extracellular matrix (ECM) stiffness is a major driver of stem cell fate. However, the involvement of the three-dimensional (3D) genomic reorganization in response to ECM stiffness remains unclear. Here, we generated comprehensive 3D chroma...
Oxygen-defect bismuth oxychloride nanosheets for ultrasonic cavitation effect enhanced sonodynamic and second near-infrared photo-induced therapy of breast cancer [0.03%]
氧空位双氯氧化铋纳米片增强乳腺癌超声造影介导的声动力及近红外二生物光动力治疗效应
Chengyuan Hong,Zhusheng Liu,Quanliang Mao et al.
Chengyuan Hong et al.
Sonodynamic therapy (SDT) relies heavily on the presence of oxygen to induce cell death. Its effectiveness is thus diminished in the hypoxic regions of tumor tissue. To address this issue, the exploration of ultrasound-based synergistic tre...
Enhancing miR-19a/b induced cardiomyocyte proliferation in infarcted hearts by alleviating oxidant stress and controlling miR-19 release [0.03%]
通过减轻氧化应激及控制miR-19释放增强心梗心脏中miR-19a/b诱导的心肌细胞增殖
Kai Wang,Jun Wen,Tian Liang et al.
Kai Wang et al.
Fully restoring the lost population of cardiomyocytes and heart function remains the greatest challenge in cardiac repair post myocardial infarction. In this study, a pioneered highly ROS-eliminating hydrogel was designed to enhance miR-19a...
Microenvironment matters: In vitro 3D bone marrow niches differentially modulate survival, phenotype and drug responses of acute myeloid leukemia (AML) cells [0.03%]
微环境起作用：体外三维骨髓生态龛不同地调节急性髓系白血病细胞的生存、表型和药物反应
Hoi Lam Cheung,Yu Hin Wong,Yuk Yin Li et al.
Hoi Lam Cheung et al.
Acute myeloid leukemia (AML) is a deadly form of leukemia with ineffective traditional treatment and frequent chemoresistance-associated relapse. Personalized drug screening holds promise in identifying optimal regimen, nevertheless, primar...
Multilayered hydrogel scaffold construct with native tissue matched elastic modulus: A regenerative microenvironment for urethral scar-free healing [0.03%]
一种用于尿道非瘢痕愈合的再生微环境的多层水凝胶支架构建体（与天然组织弹性模量相匹配）
Yangwang Jin,Ying Wang,Ranxing Yang et al.
Yangwang Jin et al.
The unsuitable deformation stimulus, harsh urine environment, and lack of a regenerative microenvironment (RME) prevent scaffold-based urethral repair and ultimately lead to irreversible urethral scarring. The researchers clarify the optima...
Efficiently directing differentiation and homing of mesenchymal stem cells to boost cartilage repair in osteoarthritis via a nanoparticle and peptide dual-engineering strategy [0.03%]
利用纳米颗粒和肽的双工程策略将间充质干细胞高效导向分化并归巢以增强骨关节炎软骨修复
Cuixi Wu,Zhenwen Huang,Jianmao Chen et al.
Cuixi Wu et al.
Mesenchymal stem cells (MSCs) are expected to be useful therapeutics in osteoarthritis (OA), the most common joint disorder characterized by cartilage degradation. However, evidence is limited with regard to cartilage repair in clinical tri...
Biomedical applications of functional hydrogels: Innovative developments, relevant clinical trials and advanced products [0.03%]
功能性水凝胶的生物医学应用：创新进展、相关临床试验和高级产品
Katrin Zöller,Dennis To,Andreas Bernkop-Schnürch
Katrin Zöller
Functional hydrogels are used for numerous biomedical applications such as tissue engineering, wound dressings, lubricants, contact lenses and advanced drug delivery systems. Most of them are based on synthetic or natural polymers forming a...
Transcriptomic profiling of human mesenchymal stem cells using a pulsed electromagnetic-wave motion bioreactor system for enhanced osteogenic commitment and therapeutic potentials [0.03%]
脉冲电磁波动力生物反应器系统对人骨髓间充质干细胞成骨分化及治疗潜能的转录组学研究
Aayushi Randhawa,Keya Ganguly,Sayan Deb Dutta et al.
Aayushi Randhawa et al.
Traditional bioreactor systems involve the use of three-dimensional (3D) scaffolds or stem cell aggregates, limiting the accessibility to the production of cell-secreted biomolecules. Herein, we present the use a pulse electromagnetic field...