Leveraging thiol-functionalized biomucoadhesive hybrid nanoliposome for local therapy of ulcerative colitis [0.03%]
利用含硫功能化生物粘附性杂合纳米脂质体局部治疗溃疡性结肠炎
Kanika,Anas Ahmad,Ajay Kumar et al.
Kanika et al.
Directly administering medication to inflamed intestinal sites for treating ulcerative colitis (UC), poses significant challenges like retention time, absorption variability, side effects, drug stability, and non-specific delivery. Recent a...
Tumor microenvironment immunomodulation by nanoformulated TLR 7/8 agonist and PI3k delta inhibitor enhances therapeutic benefits of radiotherapy [0.03%]
纳米包封的TLR 7/8激动剂和PI3Kδ抑制剂调节肿瘤微环境免疫并增强放疗疗效
Mostafa Yazdimamaghani,Oleg V Kolupaev,Chaemin Lim et al.
Mostafa Yazdimamaghani et al.
Infiltration of immunosuppressive cells into the breast tumor microenvironment (TME) is associated with suppressed effector T cell (Teff) responses, accelerated tumor growth, and poor clinical outcomes. Previous studies from our group and o...
Orchestrated metal-coordinated carrier-free celastrol hydrogel intensifies T cell activation and regulates response to immune checkpoint blockade for synergistic chemo-immunotherapy [0.03%]
由金属配位诱导的无载体 Celastrol 水凝胶增强T细胞激活和调节免疫检查点阻断疗法的响应以实现协同化疗-免疫疗法
Linying Wu,Wenmin Pi,Xuemei Huang et al.
Linying Wu et al.
The challenges generated by insufficient T cell activation and infiltration have constrained the application of immunotherapy. Making matters worse, the complex tumor microenvironment (TME), resistance to apoptosis collectively poses obstac...
Advances in meniscus tissue engineering: Towards bridging the gaps from bench to bedside [0.03%]
半月板组织工程研究进展：从实验台到病床的应用展望
Yixin Bian,Xuejie Cai,Runze Zhou et al.
Yixin Bian et al.
Meniscus is vital for maintaining the anatomical and functional integrity of knee. Injuries to meniscus, commonly caused by trauma or degenerative processes, can result in knee joint dysfunction and secondary osteoarthritis, while current c...
The past, present, and the future of disc nucleus replacement. A systematic review of a large diversity of ideas and experiences [0.03%]
髓核置换的过去、现在和未来。大量观点和经验的系统性回顾
Hans-Joachim Wilke,Vincenza Sciortino
Hans-Joachim Wilke
Disc nucleus replacement (NR) is a challenging surgical technique used as a medical treatment for early-stage disc herniation to restore disc height and the biomechanical function of a motion segment, which may reduce low back pain. The sur...
Astroglial membrane camouflaged Ptbp1 siRNA delivery hinders glutamate homeostasis via SDH/Nrf2 pathway [0.03%]
天冬酰胺结合的少突胶质细胞膜伪装的Ptbp1 siRNA递送干扰谷氨酸稳态的机制研究
Yan Liu,Jian Ren,Wenlong Zhang et al.
Yan Liu et al.
Polypyrimidine tract-binding protein 1 (PTBP1) regulates numerous alternative splicing events during tumor progression and neurogenesis. Previously, PTBP1 downregulation was reported to convert astrocytes into functional neurons; however, h...
Preventive and therapeutic effects of a super-multivalent sialylated filamentous bacteriophage against the influenza virus [0.03%]
一种抗流感病毒的超级多价唾液酸化丝状噬菌体的预防和治疗效果
Jinhyo Chung,Sehoon Kim,Jiyoon Jeong et al.
Jinhyo Chung et al.
The resurgence of influenza viruses as a significant global threat emphasizes the urgent need for innovative antiviral strategies beyond existing treatments. Here, we present the development and evaluation of a novel super-multivalent sialy...
HLA Awareness in tissue decellularization: A paradigm shift for enhanced biocompatibility, studied on the model of the human fascia lata graft [0.03%]
组织脱细胞化中的HLA意识：用于研究人类髂腰肌移植生物相容性增强的范式转换模型
Julie Manon,Robin Evrard,Louis Maistriaux et al.
Julie Manon et al.
Last twenties, tissue engineering has rapidly advanced to address the shortage of organ donors. Decellularization techniques have been developed to mitigate immune rejection and alloresponse in transplantation. However, a clear definition o...
A natural adhesive-based nanomedicine initiates photothermal-directed in situ immunotherapy with durability and maintenance [0.03%]
一种基于天然粘合剂的纳米医学发起持久性和维持性的光热原位免疫治疗
Yunhong He,Hong Sun,Hanxiao Bao et al.
Yunhong He et al.
Tumor immunotherapies have emerged as a promising frontier in the realm of cancer treatment. However, challenges persist in achieving localized, durable immunostimulation while counteracting the tumor's immunosuppressive environment. Here, ...
Highly BBB-permeable nanomedicine reverses neuroapoptosis and neuroinflammation to treat Alzheimer's disease [0.03%]
一种高度通过血脑屏障的纳米药物逆转神经凋亡和神经炎症以治疗阿尔茨海默病
Aihua Xie,Guowang Cheng,Jiaxin Wu et al.
Aihua Xie et al.
The prevalence of Alzheimer's disease (AD) is increasing globally due to population aging. However, effective clinical treatment strategies for AD still remain elusive. The mechanisms underlying AD onset and the interplay between its pathol...