Precision pore structure optimization of additive manufacturing porous tantalum scaffolds for bone regeneration: A proof-of-concept study [0.03%]
用于骨再生的增材制造多孔钽支架精确孔隙结构优化的概念验证研究
Jiale Jin,Dongyu Wang,Hu Qian et al.
Jiale Jin et al.
Currently, the treatment of bone defects in arthroplasty is a challenge in clinical practice. Nonetheless, commercially available orthopaedic scaffolds have shown limited therapeutic effects for large bone defects, especially for massiveand...
Surface modification of extracellular vesicles with polyoxazolines to enhance their plasma stability and tumor accumulation [0.03%]
聚氧氮杂环化合物修饰的细胞外囊泡增强其血浆稳定性和肿瘤积累性能
L Simon,J Constanzo,C Terraza-Aguirre et al.
L Simon et al.
Extracellular vesicles (EVs) are future promising therapeutics, but their instability in vivo after administration remains an important barrier to their further development. Many groups evaluated EV surface modification strategies to add a ...
A cuproptosis-based nanomedicine suppresses triple negative breast cancers by regulating tumor microenvironment and eliminating cancer stem cells [0.03%]
一种基于杯芳烃诱导细胞焦亡的纳米药物通过调节肿瘤微环境和消灭癌症干细胞抑制三阴性乳腺癌
Chen Xiao,Xing Wang,Shiyou Li et al.
Chen Xiao et al.
Cuproptosis is a new kind of cell death that depends on delivering copper ions into mitochondria to trigger the aggradation of tricarboxylic acid (TCA) cycle proteins and has been observed in various cancer cells. However, whether cuproptos...
Napabucasin deactivates STAT3 and promotes mitoxantrone-mediated cGAS-STING activation for hepatocellular carcinoma chemo-immunotherapy [0.03%]
纳巴布辛激活cGAS-STING促进白消安介导的肝细胞癌化免治疗
Lingzhi Wang,Shengnan Bi,Zhuo Li et al.
Lingzhi Wang et al.
The immune resistance of tumor microenvironment (TME) causes immune checkpoint blockade therapy inefficient to hepatocellular carcinoma (HCC). Emerging strategies of using chemotherapy regimens to reverse the immune resistance provide the p...
pH-responsive and nanoenzyme-loaded artificial nanocells relieved osteomyelitis efficiently by synergistic chemodynamic and cuproptosis therapy [0.03%]
一种用于高效治疗骨髓炎的pH响应型人工纳米细胞及其负载的纳米酶通过协同化学动力学和铜死亡疗法发挥作用
Yuanhui Li,Jian Li,Yuxuan Zhong et al.
Yuanhui Li et al.
Osteomyelitis is an osseous infectious disease that primarily affects children and the elderly with high morbidity and recurrence. The conventional treatments of osteomyelitis contain long-term and high-dose systemic antibiotics with debrid...
Material-driven immunomodulation and ECM remodeling reverse pulmonary fibrosis by local delivery of stem cell-laden microcapsules [0.03%]
负载干细胞的微胶囊局部给药通过材料调控免疫反应和基质重塑逆转肺纤维化
Yujie Zhang,Yuan Zhao,Chuanfeng An et al.
Yujie Zhang et al.
Recent progress in stem cell therapy has demonstrated the therapeutic potential of intravenous stem cell infusions for treating the life-threatening lung disease of pulmonary fibrosis (PF). However, it is confronted with limitations, such a...
Inflammatory stimulus-responsive polymersomes reprogramming glucose metabolism mitigates rheumatoid arthritis [0.03%]
炎症刺激响应性聚合物囊泡重编程葡萄糖代谢缓解类风湿关节炎
Qin Wang,Jianheng Ren,Xin Lin et al.
Qin Wang et al.
Inflammation-resident cells within arthritic sites undergo a metabolic shift towards glycolysis, which greatly aggravates rheumatoid arthritis (RA). Reprogramming glucose metabolism can suppress abnormal proliferation and activation of infl...
Patient-specific vascularized tumor model: Blocking monocyte recruitment with multispecific antibodies targeting CCR2 and CSF-1R [0.03%]
个性化的血管化肿瘤模型：用多特异性抗体阻断单核细胞招募CCR2和CSF-1R
Huu Tuan Nguyen,Ellen L Kan,Mouhita Humayun et al.
Huu Tuan Nguyen et al.
Tumor-associated inflammation drives cancer progression and therapy resistance, often linked to the infiltration of monocyte-derived tumor-associated macrophages (TAMs), which are associated with poor prognosis in various cancers. To advanc...
In-situ activation of biomimetic single-site bioorthogonal nanozyme for tumor-specific combination therapy [0.03%]
原位激活仿生单 site 生物正交纳米酶用于肿瘤特异性联合治疗
Mengmeng Ma,Wei Yuan,Wenbin Zhong et al.
Mengmeng Ma et al.
Copper-catalyzed click chemistry offers creative strategies for activation of therapeutics without disrupting biological processes. Despite tremendous efforts, current copper catalysts face fundamental challenges in achieving high efficienc...
Corrigendum to "Bidirectional juxtacrine ephrinB2/Ephs signaling promotes angiogenesis of ECs and maintains self-renewal of MSCs" [Biomaterials 172 (2018) 1-13] [0.03%]
“双向近距离ephrinb2/e磷信号促进内皮细胞的血管生成及维持间充质干细胞自我更新”一文中表4和图5注释的勘误公告（18年 Biomaterials，卷172，页1-13）
Cen Cao,Ying Huang,Qingming Tang et al.
Cen Cao et al.
Published Erratum
Biomaterials. 2025 Jan:312:122752. DOI:10.1016/j.biomaterials.2024.122752 2025