Intravascular delivery of an MK2 inhibitory peptide to prevent restenosis after angioplasty [0.03%]
经血管输送MK2抑制肽预防血管成形术后的再狭窄
J William Tierney,R Paolo Francisco,Fang Yu et al.
J William Tierney et al.
Peripheral artery disease is commonly treated with balloon angioplasty, a procedure involving minimally invasive, transluminal insertion of a catheter to the site of stenosis, where a balloon is inflated to open the blockage, restoring bloo...
A versatile nanoplatform carrying cascade Pt nanozymes remodeling tumor microenvironment for amplified sonodynamic/chemo therapy of thyroid cancer [0.03%]
一种多功能纳米平台载级联Pt纳米酶重塑肿瘤微环境放大甲状腺癌声动力/化疗效应
Dan Wang,Wenqi Ma,Yuanyuan Zhang et al.
Dan Wang et al.
Thyroid cancer is increasing globally, with anaplastic thyroid carcinoma (ATC) being the most aggressive type and having a poor prognosis. Current clinical treatments for thyroid cancer present numerous challenges, including invasiveness an...
Antibiotic-eluting scaffolds with responsive dual-release kinetics facilitate bone healing and eliminate S. aureus infection [0.03%]
具有响应性双重释放动力学的抗生素缓释支架促进骨修复并清除金黄色葡萄球菌感染
Eamon J Sheehy,Christian von Diemling,Emily Ryan et al.
Eamon J Sheehy et al.
Osteomyelitis (OM) is a progressive, inflammatory infection of bone caused predominately by Staphylococcus aureus. Herein, we engineered an antibiotic-eluting collagen-hydroxyapatite scaffold capable of eliminating infection and facilitatin...
Tailored extracellular matrix-mimetic coating facilitates reendothelialization and tissue healing of cardiac occluders [0.03%]
定制的细胞外基质模拟涂层可促进心脏封堵器的再内皮化和组织愈合
Yumei Qin,Yun Zhu,Lu Lu et al.
Yumei Qin et al.
Minimally invasive transcatheter interventional therapy utilizing cardiac occluders represents the primary approach for addressing congenital heart defects and left atrial appendage (LAA) thrombosis. However, incomplete endothelialization a...
Corneal stromal structure replicating humanized hydrogel patch for sutureless repair of deep anterior-corneal defect [0.03%]
用于无创修复深前部角膜缺损的人源化水凝胶补片的角膜基质结构
Long Zhao,Zhen Shi,Xia Qi et al.
Long Zhao et al.
A critical shortage of donor corneas exists worldwide. Hydrogel patches with a biological architecture and functions that simulate those of native corneas have garnered considerable attention. This study introduces a stromal structure repli...
Programmed surface platform orchestrates anti-bacterial ability and time-sequential bone healing for implant-associated infection [0.03%]
程序化表面平台调控抗菌能力及植入物相关感染的时序性骨修复
Zhou Yu,Zhaolong Wang,Yitong Chen et al.
Zhou Yu et al.
Implant-associated infection (IAI) has become an intractable challenge in clinic. The healing of IAI is a complex physiological process involving a series of spatiotemporal connected events. However, existing titanium-based implants in clin...
Mitochondrial 'Birth-Death' coordinator: An intelligent hydrogen nanogenerator to enhance intervertebral disc regeneration [0.03%]
线粒体“出生-死亡”协调器：一种智能氢纳米发电机用于增强椎间盘再生
Yucheng Ji,Yuwei Hu,Yubo Feng et al.
Yucheng Ji et al.
Currently, mitochondrial dysfunction caused by oxidative stress is a growing concern in degenerative diseases, notably intervertebral disc degeneration (IVDD). Dysregulation of the balance of mitochondrial quality control (MQC) has been con...
Tumor microenvironment ameliorative and adaptive nanoparticles with photothermal-to-photodynamic switch for cancer phototherapy [0.03%]
具有光热到光动力转换的肿瘤微环境修复和适应性纳米粒子用于癌症光疗
Le Zhang,Yuewen Yu,Keke Ding et al.
Le Zhang et al.
The notorious tumor microenvironment (TME) usually becomes more deteriorative during phototherapeutic progress that hampers the antitumor efficacy. To overcome this issue, we herein report the ameliorative and adaptive nanoparticles (TPASIC...
The immunological and pharmacokinetic evaluation of Lipid-PLGA hybrid nanoparticle-based oxycodone vaccines [0.03%]
基于脂质-PLGA杂化纳米粒的羟考酮疫苗的免疫学及药动学评价研究
Debra L Walter,Yuanzhi Bian,He Hu et al.
Debra L Walter et al.
The current opioid epidemic is one of the most profound public health crises facing the United States. Despite that it has been under the spotlight for years, available treatments for opioid use disorder (OUD) and overdose are limited to op...