Ultrasound-responsive microfibers promoted infected wound healing with neuro-vascularization by segmented sonodynamic therapy and electrical stimulation [0.03%]
分段式声动力学治疗和电刺激促进神经血管化的超声响应性微纤维促进感染伤口愈合
Xianli Wang,Ke Sun,Cheng Wang et al.
Xianli Wang et al.
Bacteria-infected wounds pose challenges to healing due to persistent infection and associated damage to nerves and vessels. Although sonodynamic therapy can help kill bacteria, it is limited by the residual oxidative stress, resulting in p...
Responsive and traceless assembly of iron nanoparticles and 131I labeled radiopharmaceuticals for ferroptosis enhanced radio-immunotherapy [0.03%]
响应性无痕组装铁纳米颗粒及131I标记放药用于铁死亡增强型放免疫治疗
Jingjing Shen,Kai Feng,Jing Yu et al.
Jingjing Shen et al.
Ferroptosis is an iron-dependent form of programmed cell death with the potential to reverse traditional cancer therapy resistance. The combination of ferroptosis with chemotherapy, photodynamic therapy and X-ray therapy has demonstrated re...
Local delivery of platelet-derived factors mitigates ischemia and preserves ovarian function through angiogenic modulation: A personalized regenerative strategy for fertility preservation [0.03%]
局部递送血小板衍生因子通过调节血管生成来减轻缺血并保持卵巢功能：一种用于生育力保存的个性化再生策略
Nanum Chung,Chungmo Yang,Heeseon Yang et al.
Nanum Chung et al.
As the most prominent and ideal modality in female fertility preservation, ovarian tissue cryopreservation, and transplantation often confront the challenge of ischemic damage and follicular loss from avascular transplantation. To surmount ...
Cyclic catalysis of intratumor Fe3+/2+ initiated by a hollow mesoporous iron sesquioxide nanoparticle for ferroptosis therapy of large tumors [0.03%]
中空介孔铁纳米粒子催化瘤内Fe3+/2+循环治疗大型肿瘤铁死亡疗法
Jing Yang,Bin Ren,Haobin Cai et al.
Jing Yang et al.
Numerous nanoparticles have been utilized to deliver Fe2+ for tumor ferroptosis therapy, which can be readily converted to Fe3+via Fenton reactions to generate hydroxyl radical (•OH). However, the ferroptosis therapeutic efficacy of large ...
Genetically engineered CD276-anchoring biomimetic nanovesicles target senescent escaped tumor cells to overcome chemoresistant and immunosuppressive breast cancer [0.03%]
基因工程CD276锚定类仿生纳米囊泡靶向衰老逃逸肿瘤细胞以克服化学抗性和免疫抑制性乳腺癌
Bin Liu,Minchao Lv,Yi Duan et al.
Bin Liu et al.
Chemotherapy-induced cellular senescence leads to an increased proportion of cancer stem cells (CSCs) in breast cancer (BC), contributing to recurrence and metastasis, while effective means to clear them are currently lacking. Herein, we ai...
Gradient conducting polymer surfaces with netrin-1-conjugation promote axon guidance and neuron transmission of human iPSC-derived retinal ganglion cells [0.03%]
gradient conducing聚合物表面带有netrin-1共轭促进人IPS衍生的视网膜神经节细胞轴突导向和神经传递
Jia-Wei She,Chia-Mei Young,Shih-Jie Chou et al.
Jia-Wei She et al.
Major advances have been made in utilizing human-induced pluripotent stem cells (hiPSCs) for regenerative medicine. Nevertheless, the delivery and integration of hiPSCs into target tissues remain significant challenges, particularly in the ...
Conversion of albumin into a BODIPY-like photosensitizer by a flick reaction, tumor accumulation and photodynamic therapy [0.03%]
白蛋白转化为类似BODIPY的光敏剂、肿瘤聚集和光动力疗法
Mengyao Yang,Yujin Kim,So-Yeon Youn et al.
Mengyao Yang et al.
The accumulation of photosensitizers (PSs) in lesion sites but not in other organs is an important challenge for efficient image guiding in photodynamic therapy. Cancer cells are known to express a significant number of albumin-binding prot...
Nanoscale octopus guiding telomere entanglement: An innovative strategy for inducing apoptosis in cancer cells [0.03%]
纳米八臂章鱼型端粒缠绕分子机器：诱导癌症细胞凋亡的新策略
Xiuping Cao,Liyang Fang,Yifan Jiang et al.
Xiuping Cao et al.
Telomere length plays a crucial role in cellular aging and the risk of diseases. Unlike normal cells, cancer cells can extend their own survival by maintaining telomere stability through telomere maintenance mechanism. Therefore, regulating...
Alginate-based artificial antigen presenting cells expand functional CD8+ T cells with memory characteristics for adoptive cell therapy [0.03%]
基于藻酸盐的人工抗原递呈细胞扩增具有记忆特性的功能性CD8+t细胞用于过继性细胞治疗
Mary O Omotoso,Savannah E Est-Witte,Sydney R Shannon et al.
Mary O Omotoso et al.
The development of artificial Antigen Presenting Cells (aAPCs) has led to improvements in adoptive T cell therapy (ACT), an immunotherapy, for cancer treatment. aAPCs help to streamline the consistent production and expansion of T cells, th...
Ligand-free biodegradable poly(beta-amino ester) nanoparticles for targeted systemic delivery of mRNA to the lungs [0.03%]
一种无配体可生物降解的聚β氨基酯纳米颗粒用于靶向递送mRNA至肺部
Erin W Kavanagh,Stephany Y Tzeng,Neeraj Sharma et al.
Erin W Kavanagh et al.
Non-viral nanoparticles (NPs) have seen heightened interest as a delivery method for a variety of clinically relevant nucleic acid cargoes in recent years. While much of the focus has been on lipid NPs, non-lipid NPs, including polymeric NP...