"All in one" lipid-polymer nanodelivery system for gene therapy of ischemic diseases [0.03%]
用于缺血性疾病基因治疗的“全合一”脂质-聚合物纳米递送系统
Youlu Chen,Ruihao Li,Xue Fu et al.
Youlu Chen et al.
Gene therapy offers a promising avenue for treating ischemic diseases, yet its clinical efficacy is hindered by the limitations of single gene therapy and the high oxidative stress microenvironment characteristic of such conditions. Lipid-p...
Multiple sclerosis treatments a review of current biomedical engineering approaches [0.03%]
多重硬化症治疗——现有生物医学工程方法综述
Sayyed Ourmazd Mohseni,Kin Man Au,Wadih Issa et al.
Sayyed Ourmazd Mohseni et al.
Multiple Sclerosis (MS) is an autoimmune condition targeting the central nervous system (CNS) characterized by focal demyelination with inflammation, causing neurodegeneration and gliosis. This is accompanied by a refractory period in relap...
NIR responsive scaffold with multistep shape memory and photothermal-chemodynamic properties for complex tissue defects repair and antibacterial therapy [0.03%]
具备多步形状记忆及光热化学动力学特性的近红外响应支架用于复杂组织缺陷修复和抗菌治疗
Tao Liu,Jie Liu,Qixuan Zhu et al.
Tao Liu et al.
Complex tissue damage accompanying with bacterial infection challenges healthcare systems globally. Conventional tissue engineering scaffolds normally generate secondary implantation trauma, mismatched regeneration and infection risks. Here...
Crystallographic plane-induced selective mineralization of nanohydroxyapatite on fibrous-grained titanium promotes osteointegration and biocorrosion resistance [0.03%]
晶体取向诱导的纳米羟基磷灰石在纤维钛基体上择优生长促进骨整合及抗生物腐蚀性能
Ruohan Wang,Juan Li,Qunjie Bi et al.
Ruohan Wang et al.
The (002) crystallographic plane-oriented hydroxyapatite (HA) and anatase TiO2 enable favorable hydrophilicity, osteogenesis, and biocorrosion resistance. Thus, the crystallographic plane control in HA coating and crystalline phase control ...
2D Janus carrier-enabled trojan horse: Gallium delivery for the sequential therapy of biofilm associated infection [0.03%]
用于生物膜相关感染序贯治疗的镓输送“特洛伊木马”二维Janus载体
Zhao Guo,Min Ge,Zesong Ruan et al.
Zhao Guo et al.
Biofilm-associated infections (BAIs) continue to pose a major challenge in the medical field. Nanomedicine, in particular, promises significant advances in combating BAIs through the introduction of a variety of nanomaterials and nano-antim...
MSCs biomimetic ultrasonic phase change nanoparticles promotes cardiac functional recovery after acute myocardial infarction [0.03%]
仿生超声介导的相变纳米颗粒促进急性心肌梗死后心脏功能恢复
Zhuo Wang,Jianfeng Chen,Jiaxu Wang et al.
Zhuo Wang et al.
Acute Myocardial Infarction (AMI) has seen rising cases, particularly in younger people, leading to public health concerns. Standard treatments, like coronary artery recanalization, often don't fully repair the heart's microvasculature, ris...
Biomimetic nanoplatform with microbiome modulation and antioxidant functions ameliorating insulin resistance and pancreatic β-cell dysfunction for T2DM management [0.03%]
一种具有调节微生物组和抗氧化功能的仿生纳米平台通过改善胰岛素抵抗和胰腺β细胞功能障碍来管理2型糖尿病
Xiudan Wang,Rui Tian,Chenghong Liang et al.
Xiudan Wang et al.
Insulin resistance and pancreatic β-cell dysfunction are the main pathogenesis of type 2 diabetes mellitus (T2DM). However, insulin therapy and diabetes medications do not effectively solve the two problems simultaneously. In this study, a...
Lele Zhang,Jiangpei Shi,Mao-Hua Zhu et al.
Lele Zhang et al.
Chemoimmunotherapy is an emerging paradigm in the clinic for treating several malignant diseases, such as non-small cell lung cancer, breast cancer, and large B-cell lymphoma. However, the efficacy of this strategy is still restricted by se...
A dendritic cell-recruiting, antimicrobial blood clot hydrogel for melanoma recurrence prevention and infected wound management [0.03%]
一种用于预防黑色素瘤复发和感染伤口管理的募集树突状细胞的抗菌血凝胶
Wen-Shang Liu,Zheng-Mao Lu,Xiao-Hui Pu et al.
Wen-Shang Liu et al.
Surgical resection, the mainstay for melanoma treatment, faces challenges due to high tumor recurrence rates and complex postoperative wound healing. Chronic inflammation from residual disease and the risk of secondary infections impede hea...
A carrier-free nanovaccine combined with cancer immunotherapy overcomes gemcitabine resistance [0.03%]
一种无载体纳米疫苗联合癌症免疫治疗可克服吉西他滨耐药性
Wen Pan,Yangyi Wang,Guiyuan Chen et al.
Wen Pan et al.
Drug resistance is a significant challenge in cancer chemotherapy and is a primary factor contributing to poor recovery for cancer patients. Although drug-loaded nanoparticles have shown promise in overcoming chemotherapy resistance, they o...