An NIR-responsive hydrogel loaded with polydeoxyribonucleotide nano-vectors for enhanced chronic wound healing [0.03%]
一种负载聚脱氧核糖核酸纳米载体的近红外响应水凝胶促进慢性伤口愈合
Yanzhen Sun,Yao Li,Xiaokang Ding et al.
Yanzhen Sun et al.
Chronic diabetic wounds are difficult to treat due to imbalanced inflammatory responses, high blood glucose levels, and bacterial infections. Novel therapeutic approaches based on nucleic acid analogues have been proposed, with unique advan...
MnO2@CeOx-GAMP radiosensitizer with oxygen vacancies depended mimicking enzyme-like activities for radiosensitization-mediated STING pathway activation [0.03%]
基于氧空位的MnO2@CeOx-GAMP类酶型放射增敏剂用于激活STING介导的放射增敏路径
Meiling Tan,Zhimin Gao,Xinyi Wang et al.
Meiling Tan et al.
Activation of the stimulator of interferon genes (STING) pathway by radiotherapy (RT) has a significant effect on eliciting antitumor immune responses. The generation of hydroxyl radical (·OH) storm and the sensitization of STING-relative ...
Functional-hydrogel-based electronic-skin patch for accelerated healing and monitoring of skin wounds [0.03%]
一种用于加速皮肤伤口愈合和监测的基于功能水凝胶的电子创可贴
Yoonsoo Shin,Hyun Su Lee,Jeong-Uk Kim et al.
Yoonsoo Shin et al.
Conductive hydrogels feature reasonable electrical performance as well as tissue-like mechanical softness, thus positioning them as promising material candidates for soft bio-integrated electronics. Despite recent advances in materials and ...
Collagen hydrogel-driven pyroptosis suppression and combined microfracture technique delay osteoarthritis progression [0.03%]
胶原蛋白水凝胶驱动的焦亡抑制和联合微骨折技术延缓骨关节炎进展
Jinzhi Meng,Jinfeng Lu,Cancai Jiang et al.
Jinzhi Meng et al.
The pathogenesis of osteoarthritis (OA), a disease causing severe medical burden and joint deformities, remains unclear. Chondrocyte death and osteochondral injury caused are the main pathological changes in OA. Thus, inhibiting chondrocyte...
Su-Ran Li,Shi-Yue Tao,Qian Li et al.
Su-Ran Li et al.
Copper (Cu), an essential micronutrient with redox properties, plays a pivotal role in a wide array of pathological and physiological processes across virtually all cell types. Maintaining an optimal copper concentration is critical for cel...
Modulating pro-fibrotic macrophages using yeast beta-glucan microparticles prepared by Pressurized Gas eXpanded liquid (PGX) Technology® [0.03%]
利用Pressurized Gas eXpanded液体(PGX)技术制备的酵母β-葡聚糖微粒调节促纤维化巨噬细胞功能
S Naiel,N Dowdall,Q Zhou et al.
S Naiel et al.
Pro-fibrotic M2-like macrophages are widely implicated in the pathogenesis and progression of lung fibrosis due to their production of pro-fibrotic growth factors and cytokines. Yeast beta-glucan (YBG) microparticles have shown potential as...
Fluorescence and photoacoustic (FL/PA) dual-modal probe: Responsive to reactive oxygen species (ROS) for atherosclerotic plaque imaging [0.03%]
用于动脉粥样硬化斑块成像的荧光和光声双模态探针：可响应活性氧物种（ROS）探针
Qianqian Yu,Yi Duan,Nian Liu et al.
Qianqian Yu et al.
Accurate and early detection of atherosclerosis (AS) is imperative for their effective treatment. However, fluorescence probes for efficient diagnosis of AS often encounter insufficient deep tissue penetration, which hinders the reliable as...
A single-chain fab derived drug conjugate for HER2 specific delivery [0.03%]
一种HER2特异递送的单链Fab衍生药物缀合物
Ruolin Xu,Yan Zheng,Wanyi Tai
Ruolin Xu
Despite the development of antibody-drug conjugates, the fragment Fab-based drug conjugates offer some unique capabilities in terms of safety, clearance, penetration and others. Current methods for preparing Fab drug conjugates are limited ...
Epidermal secretion-purified biosensing patch with hydrogel sebum filtering membrane and unidirectional flow microfluidic channels [0.03%]
具有水凝胶皮脂过滤膜和单向流微流体通道的纯化表皮分泌物生物传感器贴片
Yuqi Wang,Ziyu Zhang,Yuqing Shi et al.
Yuqi Wang et al.
The development of biosensing electronics for real-time sweat analysis has attracted increasing research interest due to their promising applications for non-invasive health monitoring. However, one of the critical challenges lies in the se...
Trojan-horse inspired nanoblaster: X-ray triggered spot attack on radio-resistant cancer through radiodynamic therapy [0.03%]
特洛伊木马纳米爆破器：X射线触发的放射动力治疗抗辐射肿瘤的定点攻击
Zhe Yang,Xiaojun Ren,Lei Li et al.
Zhe Yang et al.
Radiotherapy as a mainstay of in-depth cervical cancer (CC) treatment suffers from its radioresistance. Radiodynamic therapy (RDT) effectively reverses radio-resistance by generating reactive oxygen species (ROS) with deep tissue penetratio...