Novel platinum therapeutics induce rapid cancer cell death through triggering intracellular ROS storm [0.03%]
新型铂类药物通过诱发细胞内ROS风暴快速杀死癌细胞
Yongbin Liu,Dongfang Yu,Xueying Ge et al.
Yongbin Liu et al.
Induction of reactive oxygen species (ROS) production in cancer cells plays a critical role for cancer treatment. However, therapeutic efficiency remains challenging due to insufficient ROS production of current ROS inducers. We designed a ...
Mechanomemory of pulmonary fibroblasts demonstrates reversibility of transcriptomics and contraction phenotypes [0.03%]
肺成纤维细胞的机械记忆展示了转录组和收缩表型的可逆性
Caymen M Novak,Jana S Wheat,Samir N Ghadiali et al.
Caymen M Novak et al.
Fibroblasts are cells responsible for producing extracellular matrix (ECM) components, which provides physical support for organs. Although these mesenchymal cells are responsive to mechanical cues in their environment, the permanence of th...
Engineering extracellular vesicles derived from endothelial cells sheared by laminar flow for anti-atherosclerotic therapy through reprogramming macrophage [0.03%]
工程化内皮细胞来源的层流剪切外泌体通过重编程巨噬细胞用于抗动脉粥样硬化治疗
Chunli Li,Fei Fang,Erxiang Wang et al.
Chunli Li et al.
Extracellular vesicles (EVs) secreted by endothelial cells in response to blood laminar flow play a crucial role in maintaining vascular homeostasis. However, the potential of these EVs to modulate the immune microenvironment within plaques...
Yuqin Xiao,Kaige Xu,Peng Zhao et al.
Yuqin Xiao et al.
Wound healing concerns almost all bed-side related diseases. With our increasing comprehension of healing nature, the physical and chemical natures behind the wound microenvironment have been decoupled. Wound care demands timely screening a...
Harnessing Nature's ingenuity to engineer butterfly-wing-inspired photoactive nanofiber patches for advanced postoperative tumor treatment [0.03%]
借鉴自然的智慧，利用蝴蝶翅膀的原理设计光活性纳米纤维补丁用于术后肿瘤治疗
Hao Zheng,Kerong Chen,Yitong Dun et al.
Hao Zheng et al.
Postoperative tumor treatment necessitates a delicate balance between eliminating residual tumor cells and promoting surgical wound healing. Addressing this challenge, we harness the innovation and elegance of nature's ingenuity to develop ...
Enteric-coated cerium dioxide nanoparticles for effective inflammatory bowel disease treatment by regulating the redox balance and gut microbiome [0.03%]
enteric-coated纳米二氧化铈通过调节氧化还原平衡和肠道微生物群进行有效治疗炎症性肠病
Yubiao Huang,Jiaqi Xu,Ge Sun et al.
Yubiao Huang et al.
Reactive oxygen species (ROS) play crucial roles in the pathogenesis of inflammatory bowel disease (IBD) by disrupting the mucosal barrier and subsequently leading to the dysregulation of the gut microbiome. Therefore, ROS scavengers presen...
Topological polymeric glucosyl nanoaggregates in scaffold enable high-density piscine muscle tissue [0.03%]
介观支架中的拓扑聚合聚葡糖纳米聚集体促进高密度鱼类肌肉组织生长
Ruihao Niu,Qipu Xin,Jihui Lao et al.
Ruihao Niu et al.
Upon the pressure of conventional land agriculture and marine environment facing the future of human beings, the emerging of alternative proteins represented by cultured meat is expected with a breakthrough of efficient, safe and sustainabl...
Magnetic mesoporous silica nanoparticles loaded with peptides for the targeted repair of cavernous nerve injury underlying erectile dysfunction [0.03%]
用于靶向修复治疗勃起功能障碍海绵体神经损伤的载多肽磁性介孔硅纳米粒子
Xiaojie Liang,Zhu Wang,Shuting Wang et al.
Xiaojie Liang et al.
Erectile dysfunction (ED) is a common male sexual disorder characterized by repeated or persistent difficulty in achieving or maintaining an erection. It can arise from various factors, with cavernous nerve injury (CNI) from radical prostat...
Redesigned chondroitinase ABC degrades inhibitory chondroitin sulfate proteoglycans in vitro and in vivo in the stroke-injured rat brain [0.03%]
改良的软骨素酶ABC可降解中风大鼠脑内的抑制性硫酸皮肤素蛋白聚糖
Nitzan Letko Khait,Sabrina Zuccaro,Dhana Abdo et al.
Nitzan Letko Khait et al.
Injuries to the central nervous system, such as stroke and traumatic spinal cord injury, result in an aggregate scar that both limits tissue degeneration and inhibits tissue regeneration. The aggregate scar includes chondroitin sulfate prot...
Dynamic monitoring of a 3D-printed airway tissue model using an organic electrochemical transistor [0.03%]
基于有机电化学晶体管的三维打印气道组织模型动态监测
Seungjin Chai,Yunji Lee,Róisín M Owens et al.
Seungjin Chai et al.
Assessing the transepithelial resistance to ion flow in the presence of an electric field enables the evaluation of the integrity of the epithelial cell layer. In this study, we introduce an organic electrochemical transistor (OECT) interfa...