A recombinant collagen-based nanocomposite hydrogel for programmable full-cycle intelligent management of infected wounds [0.03%]
一种用于程序化全程智能化感染伤口管理的重组胶原基纳米复合水凝胶
Yufeng Li,Jia Wang,Yarong Ding et al.
Yufeng Li et al.
Infected wound healing is a highly dynamic, multistage process, yet most wound dressings remain functionally static and incapable of adapting to its evolving microenvironment. Here, we develop a nanocomposite hydrogel that enables programma...
Oncolytic virus-drug conjugates for increased viral replication efficiency and potentiated cancer chemoimmunotherapy [0.03%]
一种用于增强病毒复制效率和增强癌症化疗免疫疗法的溶瘤病毒-药物共轭体
Tao Zhang,Weiyue Ban,Chengda Yan et al.
Tao Zhang et al.
Oncolytic viruses (OVs) therapy is limited by poor systemic delivery efficiency to tumors, low intratumoral replication efficiency and insufficient immune activation against malignant cancers. Here, we report the autophagy-activated oncolyt...
Engineered senescence-targeting apoptotic extracellular vesicles-laden injectable hydrogel microspheres mitigating nucleus pulposus cell ferroptosis against intervertebral disc degeneration [0.03%]
一种靶向衰老细胞的凋亡型外泌体-载药水凝胶微球缓释体系对抗椎间盘退变中的铁死亡作用机制研究
Pengzhi Shi,Zhuo-Ran Yang,Wenbo Wu et al.
Pengzhi Shi et al.
As the rapid growth of aging population, intervertebral disc degeneration (IVDD) becomes a prevalent degenerative disorder in clinical practice. Ferroptosis-induced senescence in nucleus pulposus cells (NPCs) represents a primary pathologic...
Self-powered photothermal-thermoelectric bioelectronic dressings combined with antioxidant immune regulation accelerate diabetic infected wounds healing [0.03%]
一种自供电光热-热电生物电子绷带结合抗氧化免疫调节加速糖尿病感染创面愈合
Xue Yuan,Jiacheng Shi,Yuhan Zhang et al.
Xue Yuan et al.
Chronic diabetic wounds are plagued by problems such as severe infection, oxidative stress, persistent inflammation. Here, we present an innovative dual-mode thermoelectric bio-dressing that synergistically addresses the multifactorial chal...
Cationic bakuchiol-loaded lipid nanoparticles enhance skin permeation and modulate neuro-immune inflammation and itch pathways in atopic dermatitis [0.03%]
阳离子补骨脂素药用脂质纳米颗粒增强皮肤渗透并调节特应性皮炎的神经免疫炎症和瘙痒通路
Hyung-Goo Kim,Yeon-Hee Shin,Jin Hyun Kim et al.
Hyung-Goo Kim et al.
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by recurrent pruritus and epidermal barrier dysfunction. The long-term use of topical corticosteroids is limited by local and systemic adverse effects, including s...
A biomimetic urethral scaffold with spatiotemporally coordinated functions promotes scar-free urethral healing through barrier protection and regenerative microenvironment remodeling [0.03%]
一种具有时空协调功能的仿生尿道支架通过屏障保护和修复微环境重塑促进无瘢痕尿道愈合
Li-Ping Huang,Wen-Qian Zhang,Qian-Jin Li et al.
Li-Ping Huang et al.
The integrity of the urethral epithelium is critical for functional urethral reconstruction. Once disrupted, persistent exposure of the injured wound to the harsh urinary microenvironment triggers inflammatory responses, hampers re-epitheli...
High-resolution fabrication of porous microtubular scaffolds for vascular tissue engineering using two-photon stereolithography [0.03%]
采用两光子立体光刻技术制造用于血管组织工程的多孔微管状支架
Johanna Vetter,Anna Fritschen,Laura Teppe et al.
Johanna Vetter et al.
Providing transport routes for oxygen and nutrient supply in macroscopic tissue remains a major challenge in tissue engineering. Among fabrication methods for perfusable microtubular structures, two-photon stereolithography (TPS) stands out...
Functional characterization of obesity using advanced 3D in vitro adipose tissue models [0.03%]
利用高级三维体外脂肪组织模型对肥胖的功能表征
Vera M Pieters,Kyle S Nguyen,Penney M Gilbert et al.
Vera M Pieters et al.
Obesity represents a complex systemic disease resulting in the global metabolic syndrome epidemic, yet our understanding of the underlying mechanisms in adipose tissue driving obesity remains limited. As the primary cellular targets of incr...
Mehmoona Azmat,Wenjin Li
Mehmoona Azmat
The integration of artificial intelligence (AI) into biomolecular and materials science is reshaping the design, optimization, and translation of functional biomaterials. Although empirical screening and iterative experimentation remain ind...
Synthesis and preclinical evaluation of a bismuth pyclen chelate with superior water solubility, high stability, and low osmolarity for multisystem CT imaging in vivo [0.03%]
一种具有优异水溶性、高稳定性和低渗透压的用于活体多系统CT成像的吡克里
Jianqi Deng,Yuping Zhang,Ke Xiang et al.
Jianqi Deng et al.
Bismuth chelates represent promising alternatives to clinical iodinated contrast agents for computed tomography (CT) imaging, given their higher X-ray attenuation and favorable safety profiles. However, achieving an optimal balance among im...