Self-organizing bioceramic granules with wave-dissipating architectures for bone void filling [0.03%]
一种用于骨缺损填充的自组织生物陶瓷颗粒及其波耗散结构
Zhengyi Xing,Zihao Dong,Puxin Liu et al.
Zhengyi Xing et al.
Granular bone substitutes readily adapt to irregular defects but lack initial stability, often resulting in granule migration and clinical complications. Inspired by the structural stability of wave-dissipating concrete blocks, which protec...
Lipo-protein deposition strategy towards smart microspheres with bacterial toxin triggered "adsorption-pore formation-immune regulation" cascade reaction for sepsis treatment [0.03%]
基于细菌外毒素触发“吸附-成孔-免疫调节”级联反应的智能微球的设计合成及吸附机制研究
Ziyue Ling,Xijing Yang,Xianda Liu et al.
Ziyue Ling et al.
Sepsis induced by Gram-positive bacteria causes immune disorder and multi-organ damage driven by pore-forming toxins (PFTs), which directly form pores on host cell membrane and exacerbate cell damage. Traditional drug therapy cannot remove ...
Hierarchical engineering of mesoporous polydopamine for "homologous targeting-cascade blasting" biomimetic phototheranostic nanotrident [0.03%]
分层工程化介孔多巴胺用于_homologous_靶向-级联爆破的仿生光诊疗纳米三叉武器
Yuhang Huang,Yuanyuan Ma,Shaowen Liu et al.
Yuhang Huang et al.
The activation of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway represents a promising strategy for eliciting host immune responses to eradicate tumors. However, the clinical application of STING agonists...
Cytokine co-presentation on targeted lipid nanoparticles enhances in vivo T cell engineering [0.03%]
靶向脂质纳米颗粒上的细胞因子共呈现可增强体内T细胞工程化效果
Milan Patel,Joseph Choy,Leonardo Cheng et al.
Milan Patel et al.
T lymphocytes are attractive cellular targets for gene therapy and cell engineering, due to their critical role in adaptive immunity; however, efficient in vivo T cell transfection remains challenging. Antibody-conjugated lipid nanoparticle...
Harnessing Chlorella vulgaris-derived extracellular vesicles for potentiated cancer immunotherapy [0.03%]
利用小球藻来源的细胞外囊泡增强癌症免疫治疗
Fanqiang Meng,Chi Zhang,Yumeng Ma et al.
Fanqiang Meng et al.
Plant-derived extracellular vesicles (EVs) have emerged as promising drug delivery vehicle due to their inherent biocompatibility, high stability and large-scale production. Chlorella vulgaris (C. vulgaris) has been increasing application i...
Energy-responsive multi-catalytic nanogenerator hydrogels synergistically enhance diabetic tendon-to-bone healing via the ages/RAGE/PIEZO2 axis [0.03%]
能量响应型多催化纳米发生器水凝胶通过AGES/RAGE/PIEZO2轴协同促进糖尿病肌腱-骨愈合
Yaqi Hua,Wenqi Duan,Runhui Liu et al.
Yaqi Hua et al.
Rotator cuff tears (RCTs) represent a significant clinical challenge with high post-operative re-tear rates, especially in diabetic patients. Through comprehensive bioinformatic analysis of a publicly available transcriptomic dataset (GSE23...
Mechanically regulated proteostasis by Hsp27 governs osteogenesis of mesenchymal stromal cells on soft matrices [0.03%]
肌成纤维细胞在软基质上通过Hsp27的机械调节蛋白稳定作用来控制骨发生过程
Ming-Chung Wu,Cheng-Te Hsiao,Wan-Yu Chiang et al.
Ming-Chung Wu et al.
Matrix stiffness is a critical biophysical cue that governs mesenchymal stromal cell (MSC) fate, yet the molecular mechanisms by which soft extracellular environments impair osteogenesis remain poorly defined. In this study, we utilized a s...
Photothermal targeting of lactate metabolism reverses radioresistance via disrupting the immunosuppressive barrier [0.03%]
光热靶向乳酸代谢通过破坏免疫抑制屏障逆转放射耐药性
Hongpei Deng,Liyang Zhou,Hao Tian et al.
Hongpei Deng et al.
Radiotherapy (RT) is frequently compromised by radioresistance and insufficient immunogenicity. Multiomics analysis here identifies a significant association between glycolysis and DNA damage repair, linking them to RT resistance and poor p...
Deep-penetrating tetrahedral framework nucleic acid nanogel spray restores miRNA-223 to potentiate macrophage-driven angiogenesis for deep tissue pressure injuries [0.03%]
一种深层渗透四面体框架核酸纳米凝胶喷雾恢复miR-223以促进巨噬细胞驱动的血管生成用于深度组织压力损伤
Xiaofeng Su,Sirong Shi,Ke Xu et al.
Xiaofeng Su et al.
Deep tissue pressure injuries (DTPI) are clinically recalcitrant due to a "dual-barrier" challenge: the dense necrotic tissue that physically impedes drug penetration and the enzymatic microenvironment that accelerates drug degradation. Her...
Combating oxidative stress resistance in copper-mediated chemodynamic therapy through redox metabolism regulation [0.03%]
通过红氧代谢调节对抗铜介导的化学动力学治疗中的氧化应激耐受性
Shihong Wu,Hang Qian,Hang Zhao et al.
Shihong Wu et al.
Redox metabolism in tumor cells is considered a vulnerable target for cancer therapy. Benefiting from the elevated copper-ion levels characteristic of tumorigenesis and progression, copper-mediated chemodynamic therapy (Cu-CDT) demonstrates...