IFN-γ and TLR agonist co-adjuvants enhance the efficacy of a lipid-PLGA hybrid nanoparticle-based oxycodone vaccine [0.03%]
干扰素和TLR激动剂协同增强脂质-PLGA纳米粒子载镇痛药疫苗的疗效研究
Yuanzhi Bian,Qiaoqiao Ci,Kobra Rostamizadeh et al.
Yuanzhi Bian et al.
The ongoing opioid epidemic continues to drive high rates of substance use disorders (SUD), fatal and non fatal overdoses, with oxycodone being one of the most widely misused prescription opioids. Immunopharmacological strategies such as va...
Restoration of p53 mRNA combined with BRD4 silencing by brain targeted nanocapsules achieves effective combinatorial treatment of glioblastoma [0.03%]
脑靶向纳米囊泡介导的p53 mRNA递送联合BRD4沉默有效治疗胶质母细胞瘤
Yujing Sang,Yunge Cao,Shanshan Li et al.
Yujing Sang et al.
Glioblastoma (GB) is a highly malignant and the most lethal intracranial tumor. p53 mutations in GB patients, occurring in 30-50 % of cases, disrupt tumor-suppressive pathways and promote malignant progression. Advances in mRNA technology e...
Tailoring imaging probes for defining glioma invasive margins: Tracing the molecular footprints of cancer cells [0.03%]
针对胶质瘤浸润边缘的影像探针的设计：追踪肿瘤细胞的分子足迹
Qian He,Minghao Yang,Pengwei Wang et al.
Qian He et al.
Maximal safe surgical resection remains the cornerstone of glioma treatment, yet the infiltrative nature of this most common malignant brain tumor poses major challenges in accurately delineating tumor margins while preserving adjacent func...
"In situ endothelial modulation and transduction" strategy driven by biomimetic H2S delivery system for targeted repair of vascular injury [0.03%]
一种仿生型H2S递送系统驱动的“原位内皮调控和转导”策略用于血管损伤的靶向治疗
Bin Gao,Yibin Zhang,Xiaofen Huang et al.
Bin Gao et al.
Vascular recanalization mediated by the interventional therapy can reduce cardio-cerebrovascular disease burden. However, its long-term outcomes are often undesired owing to (1) inevitable mechanical damage to the vasculature that triggers ...
Nanoparticle-mediated antagonism of sustained endosomal signaling of the calcitonin receptor-like receptor provides enhanced and persistent relief of oral cancer pain [0.03%]
纳米颗粒介导的降钙素基因相关肽受体长效内吞信号通路拮抗作用可增强并持久缓解口腔癌疼痛
Chloe J Peach,Nguyen Huu Tu,Parker K Lewis et al.
Chloe J Peach et al.
By improving the delivery and tumor retention of chemotherapeutics, nanomedicines hold potential for cancer treatment. The usefulness of nanoparticle (NP)-encapsulated analgesics for the cancer pain treatment is comparatively unexplored. We...
Blood-testis barrier-crossing extracellular vesicles for asthenozoospermia therapy via synergistic ATP replenishment and ferroptosis suppression [0.03%]
通过协同补充ATP和抑制铁死亡治疗弱精症的血睾屏障穿行型细胞外囊泡疗法
Xinghua Yu,Lingan Zeng,Haiyan Chen et al.
Xinghua Yu et al.
Asthenozoospermia, a leading cause of male infertility characterized by impaired sperm motility, poses significant therapeutic challenges due to the restrictive blood-testis barrier (BTB). To address this limitation, we engineered multifunc...
NIR-II fluorescence membrane probes for rapidly labelling hybrid of probiotic outer membrane vesicles and anti-PD-L1 scFv over-expressing cellular vesicles with targeted photothermal-immunotherapy of colon cancer [0.03%]
近红外二区荧光膜探针快速标记益生菌外泌体与抗PD-L1单链抗体高表达细胞源性胞外囊泡杂交体用于结肠癌靶向光热免疫治疗
Chen Yu,Ziwei Hu,Genwen Hu et al.
Chen Yu et al.
Lipid-bilayer structured nanovectors (LBSNs) (e.g., liposomes and biomimetic vesicles) are burgeoning for diagnosis and therapy, and fluorescence labelling is often conducted for biodistribution tracing with visible/NIR-I fluorescence membr...
Multifunctional hydrogel delivery of mesenchymal stem cell secretome suppresses neutrophil extracellular trap formation and promotes diabetic wound healing via PGE2/BMAL1 pathway [0.03%]
多功能水凝胶递送间充质干细胞分泌组通过PGE2 / BMAL1途径抑制中性粒细胞胞外陷阱的形成并促进糖尿病伤口愈合
Lulu Lin,Xiao Liang,Zhihong Xu et al.
Lulu Lin et al.
Excessive formation of neutrophil extracellular traps (NETs) significantly impedes diabetic wound healing. Although conditioned medium of mesenchymal stem cells (MSC-CM) has shown therapeutic potential due to its anti-inflammatory, antioxid...
Temporal-spatial hierarchical immunomodulating dressing promotes high-quality wound healing through M2 macrophage balancing [0.03%]
时间空间分层免疫调节敷料通过M2巨噬细胞平衡促进高质量伤口愈合
Yu Hu,Nianhao Xie,Ci Shi et al.
Yu Hu et al.
The skin is a highly complex organ with multiple layers and diverse cell types, each residing in specific locations. Effective wound healing requires precise coordination of cellular activities both temporally and spatially. However, this s...
3D perfusable minichannels stented with matrix bound vesicles derived from gingival mesenchymal stem cells ameliorated granuloma-related stenosis and improved survival in a rabbit tracheal replacement model [0.03%]
兔气管移植模型中3D血管化微通道修复肉芽肿相关狭窄并提高生存率：牙龈间充质干细胞源性基质结合囊泡作为支架的作用
Bing Liu,Xinchi Zhang,Na Wei et al.
Bing Liu et al.
Successful tracheal regeneration remains a significant challenge in tracheal replacement, with tracheal stenosis posing a major obstacle. Decellularized extracellular matrices (dECMs) are emerging as promising alternatives for tissue engine...