A pancreatic cancer organoid incorporating macrophages reveals the correlation between the diversity of tumor-associated macrophages and cancer cell survival [0.03%]
一种包含巨噬细胞的胰腺癌类器官揭示了肿瘤相关巨噬细胞多样性与癌细胞生存之间的关联
Shunsuke Tabe,Kenta Takeuchi,Kenji Aoshima et al.
Shunsuke Tabe et al.
Pancreatic ductal adenocarcinoma (PDAC) is a progressive cancer with a poor prognosis. It contains a complex tumor microenvironment (TME) that includes various stromal cell types. Comprehending cellular communications within the TME is diff...
Yingying Shi,Jiapeng Mao,Sijie Wang et al.
Yingying Shi et al.
Messenger RNA (mRNA)-based immunotherapies and protein in situ production therapies hold great promise for addressing theoretically all the diseases characterized by aberrant protein levels. The safe, stable, and precise delivery of mRNA to...
Smart filtering facepiece respirator with self-adaptive fit and wireless humidity monitoring [0.03%]
具有自适应贴合和无线湿度监测的智能过滤式面罩呼吸器
Kangkyu Kwon,Yoon Jae Lee,Yeongju Jung et al.
Kangkyu Kwon et al.
The widespread emergence of airborne diseases has transformed our lifestyle, and respirators have become an essential part of daily life. Nevertheless, finding respirators that fit well can be challenging due to the variety of human facial ...
Immunomodulatory hydrogel orchestrates pro-regenerative response of macrophages and angiogenesis for chronic wound healing [0.03%]
免疫调节水凝胶通过调节巨噬细胞和血管生成促进慢性伤口愈合
Chen-Hsiang Kuan,Ling Chang,Chia-Yu Ho et al.
Chen-Hsiang Kuan et al.
Chronic wound healing often encounters challenges characterized by prolonged inflammation and impaired angiogenesis. While the immune response plays a pivotal role in orchestrating the intricate process of wound healing, excessive inflammat...
Sustained therapeutic effects of self-assembled hyaluronic acid nanoparticles loaded with α-Ketoglutarate in various osteoarthritis stages [0.03%]
自组装透明质酸纳米颗粒载α-酮戊二酸治疗各阶段骨关节炎的长效性研究
Xinli Wang,Yufei Xue,Kaili Hao et al.
Xinli Wang et al.
Osteoarthritis (OA) is a prevalent degenerative disease characterized by irreversible destruction of articular cartilage, for which no current drugs are known to modify its progression. While intra-articular (IA) injections of hyaluronic ac...
Targeted V-type peptide-decorated nanoparticles prevent colitis by inhibiting endosomal TLR signaling and modulating intestinal macrophage polarization [0.03%]
V型肽修饰的靶向纳米颗粒通过抑制内体TLR信号传导和调节肠道巨噬细胞极化来预防结肠炎
Tongxuan Li,Qianqian Li,Sixia Liu et al.
Tongxuan Li et al.
Inflammatory bowel disease (IBD) has become a serious and challenging health problem globally without curative medical treatments. Mounting evidence suggests that intestinal macrophages and their phenotypes are key players in the pathogenes...
Direct extrusion of multifascicle prevascularized human skeletal muscle for volumetric muscle loss surgery [0.03%]
用于体积肌肉损失手术的多肌束预血管化人体骨骼肌的直接挤出
Van Thuy Duong,Thao Thi Dang,Van Phu Le et al.
Van Thuy Duong et al.
Skeletal muscle is composed of multiple fascicles, which are parallel bundles of muscle fibers surrounded by connective tissues that contain blood vessels and nerves. Here, we fabricated multifascicle human skeletal muscle scaffolds that mi...
Tertiary lymphoid structure formation induced by LIGHT-engineered and photosensitive nanoparticles-decorated bacteria enhances immune response against colorectal cancer [0.03%]
LIGHT工程细菌和光热纳米粒子修饰的细菌诱导三级淋巴器官的形成可增强对结直肠癌免疫应答
Lijun Hu,Tan Li,Shaohui Deng et al.
Lijun Hu et al.
Tertiary lymphoid structures (TLSs) are known to enhance the prognosis of patients with colorectal cancer (CRC) by fostering an immunologically active tumor microenvironment (TME). Inducing TLS formation therapeutically holds promise for tr...
Multifaceted bone response to immunomodulatory magnesium implants: Osteopromotion at the interface and adipogenesis in the bone marrow [0.03%]
镁基免疫调控骨植入体的多维骨响应：界面处的促骨生成和骨髓中的类脂代谢分化反应
Heithem Ben Amara,Diana C Martinez,Kamila Iskhakova et al.
Heithem Ben Amara et al.
Orthopedic implants made of biodegradable magnesium (Mg) provide an alternative to nondegradable implants for fracture repair. Widely reported to be pro-osteogenic, Mg implants are also believed to be anti-inflammatory and anti-osteoclastic...
Reprogramming tumor microenvironment with precise photothermal therapy by calreticulin nanobody-engineered probiotics [0.03%]
基于钙网蛋白纳米抗体工程的益生菌精准光热重编程肿瘤微环境
Liuhai Zheng,Huifang Wang,Xiaoru Zhong et al.
Liuhai Zheng et al.
Targeted therapies have revolutionized traditional cancer treatments by precisely targeting tumor cells, enhancing efficacy and safety. Despite this advancement, the proportion of cancer patients eligible for such therapies remains low due ...