LDH nanoparticles-doped cellulose nanofiber scaffolds with aligned microchannels direct high-efficiency neural regeneration and organized neural circuit remodeling through RhoA/Rock/Myosin II pathway [0.03%]
负载LDH纳米粒子的纤维素纳米纤维支架通过重塑规则神经电路调节高效轴突生长和导向
Xuening Pang,Tongling Zhang,Jiazheng Li et al.
Xuening Pang et al.
Spinal cord injury (SCI) triggers interconnected malignant pathological cascades culminating in structural abnormalities and composition changes of neural tissues and impairs spinal cord tissue function. Cellulose nanofibers (CNF) have cons...
Tumor microenvironment-activated polypeptide nanoparticles for oncolytic immunotherapy [0.03%]
肿瘤微环境活化的多肽纳米颗粒的溶瘤免疫治疗研究
Zhihui Guo,Tianze Huang,Xueli Lv et al.
Zhihui Guo et al.
Cationic oncolytic polypeptides have gained increasing attention owing to their ability to directly lyse cancer cells and activate potent antitumor immunity. However, the low tumor cell selectivity and inherent toxicity induced by positive ...
Enhancing CAR-T cell therapy against solid tumor by drug-free triboelectric immunotherapy [0.03%]
无载药摩擦电免疫治疗增强CAR-T细胞对抗实体瘤疗法
Haimei Li,Zichen Wang,Yulin Hu et al.
Haimei Li et al.
Chimeric antigen receptor (CAR) T cell therapy is a highly effective immunotherapy for hematological tumors, but its efficacy against most solid tumors remains challenging. Herein, a novel synergistic combination therapy of drug-free triboe...
Gamabufotalin loaded micro-nanocomposites for multimodal therapy of metastatic TNBC by efficiently inducing ICD [0.03%]
高效的诱导ICD的Gamabufotalin载药微纳复合材料用于转移性三阴乳腺癌多模态治疗研究
Jialong Fan,Yan Qin,Wensheng Qiu et al.
Jialong Fan et al.
Gamabufotalin (CS-6), a main active compound derived from Chinese medicine Chansu, exhibits a robust inhibitory effect on programmed death-ligand 1 (PD-L1) in triple-negative breast cancer (TNBC) cells. Despite its potential for tumor thera...
Maintaining myoprotein and redox homeostasis via an orally recharged nanoparticulate supplement potentiates sarcopenia treatment [0.03%]
通过口服充电的纳米颗粒补充剂维持肌蛋白和氧化还原稳态以增强肌少症治疗效力
Yang Yu,Xuehan Jiang,Tianhao Yu et al.
Yang Yu et al.
Sarcopenia is a progressive skeletal muscle disorder characterized by the accelerated loss of muscle mass and function, with no promising pharmacotherapies. Understanding the imbalance of myoprotein homeostasis within myotubes, which causes...
Kishwor Poudel,Tulasi Vithiananthan,Jong Oh Kim et al.
Kishwor Poudel et al.
Vaccine science, nanotechnology, and immunotherapy are at the forefront of cancer treatment strategies, each offering significant potential for enhancing tumor-specific immunity and establishing long-lasting immune memory to prevent tumor r...
Engineering hirudin encapsulation in pH-responsive antioxidant nanoparticles for therapeutic efficacy in ischemic stroke model mice [0.03%]
工程化蚯蚓凝血酶抑制剂包载抗氧化响应纳米粒用于缺血性脑卒中治疗效应研究
Ting Mei,Peiwen Zhang,Yifan Hu et al.
Ting Mei et al.
This study introduces a novel pH-sensitive, hirudin-loaded antioxidant nanoparticle (HD@iNanoAOX) aimed at addressing the challenges of hirudin's short half-life and hemorrhagic transformation. HD@iNanoAOX was engineered to safeguard and pr...
Ke Zhang,Shijie Li,Jiaying Li et al.
Ke Zhang et al.
The emergence of precision cancer treatment has triggered a paradigm shift in the field of oncology, facilitating the implementation of more effective and personalized therapeutic approaches that enhance patient outcomes. The pH of the tumo...
Macrophage corpses for immunoregulation and targeted drug delivery in treatment of collagen-induced arthritis mice [0.03%]
用于治疗胶原诱导性关节炎小鼠的免疫调节和靶向药物传输的巨噬细胞“尸体”
Yuhuan Li,Jiayin Lv,Shuchen Liu et al.
Yuhuan Li et al.
The role of pro-inflammatory macrophages (M1) in rheumatoid arthritis (RA) is significant, as they produce excessive cytokines. Targeting efferocytosis is a potential manner to repolarize M1 macrophages into pro-resolving M2 phenotype, whic...
Macrophage microRNA-146a is a central regulator of the foreign body response to biomaterial implants [0.03%]
巨噬细胞微小核糖核酸-146a是生物材料植入后异物反应的中央调节因子
Manisha Mahanty,Bidisha Dutta,Wenquan Ou et al.
Manisha Mahanty et al.
Host recognition and immune-mediated foreign body response (FBR) to biomaterials can adversely affect the functionality of implanted materials. FBR presents a complex bioengineering and medical challenge due to the lack of current treatment...