Yanfei Zhao,Seungbeom Lee,Tingyu Long et al.
Yanfei Zhao et al.
Neuromorphic electronics use neural models in hardware to emulate brain-like behavior, and provide power-efficient, extremely compact, and massively-parallel processing, so they are ideal candidates for next-generation information-processin...
Electrically-stimulated cellular and tissue events are coordinated through ion channel-mediated calcium influx and chromatin modifications across the cytosol-nucleus space [0.03%]
电刺激诱发的细胞和组织事件通过跨细胞质-细胞核空间的离子通道介导的钙流入和染色质修饰进行协调
Shanika Karunasagara,Buuvee Bayarkhangai,Hye-Won Shim et al.
Shanika Karunasagara et al.
Electrical stimulation (ES) through biomaterials and devices has been implicated in activating diverse cell behaviors while facilitating tissue healing process. Despite its significance in modulating biological events, the mechanisms govern...
Biomimetic polymeric nanoreactors with photooxidation-initiated therapies and reinvigoration of antigen-dependent and antigen-free immunity [0.03%]
具有光氧化引发疗法和依赖抗原及无抗原免疫活化的仿生聚合纳米反应器
Pu Qiu,Mei Wen,Zixuan Zhuang et al.
Pu Qiu et al.
Immune cell-mediated anticancer modalities usually suffer from immune cell exhaustion and limited efficacy in solid tumors. Herein, the oxygen-carrying biomimetic nanoreactors (BNR2(O2)) have been developed with photooxidation-driven therap...
The use of a multi-metric readout screen to identify EHMT2/G9a-inhibition as a modulator of cancer-associated fibroblast activation state [0.03%]
利用多指标读数屏识别EHMT2/G9a抑制作为调节癌相关成纤维细胞活化状态的因子
Nila C Wu,Rene Quevedo,Michelle Nurse et al.
Nila C Wu et al.
Cancer-associated fibroblasts (CAFs) play a pivotal role in cancer progression, including mediating tumour cell invasion via their pro-invasive secretory profile and ability to remodel the extracellular matrix (ECM). Given that reduced CAF ...
Development of keratin-based fibers fabricated by interfacial polyelectrolyte complexation for suture applications [0.03%]
基于角蛋白的界面聚电解质复合材料缝合线的开发研究进展
Laura Li-En Foo,Muthualagu Natarajan Logeshwari,Bertrand Czarny et al.
Laura Li-En Foo et al.
Interfacial Polyelectrolyte Complexation (IPC) is a convenient way to produce composite, micro-scale fibers. In this paper, we report the successful development of novel keratin-based IPC fibers and also demonstrate the feasibility of using...
Bifunctional mesoporous HMUiO-66-NH2 nanoparticles for bone remodeling and ROS scavenging in periodontitis therapy [0.03%]
bifunctional介孔HMUiO-66-NH2纳米粒子在牙周炎治疗中的骨重塑和ROS清除作用
Waishan Lam,Yufei Yao,Chenxi Tang et al.
Waishan Lam et al.
Periodontal bone defects represent an irreversible consequence of periodontitis associated with reactive oxygen species (ROS). However, indiscriminate removal of ROS proves to be counterproductive for tissue repair and insufficient for addr...
Helicobacter pylori VacA-induced mitochondrial damage in the gastric pit cells of the antrum and therapeutic rescue [0.03%]
幽门螺旋杆菌VacA诱导胃窦腔上皮细胞线粒体损伤及治疗修复
Ye Seul Son,Yong Hwan Kwon,Moo-Seung Lee et al.
Ye Seul Son et al.
Exploring host cell specificity, pathogenicity, and molecular mechanisms of the vacuolating cytotoxin A (VacA), secreted by Helicobacter pylori (Hp) is crucial for developing novel treatment strategies. VacA affects subcellular events, part...
Revolutionizing pressure ulcer regeneration: Unleashing the potential of extracellular matrix-derived temperature-sensitive injectable antioxidant hydrogel for superior stem cell therapy [0.03%]
革命性压力溃疡再生：利用可注射抗氧化水凝胶释放细胞外基质潜在价值以实现更佳的干细胞治疗
Junjie Tang,Penglei Zhang,Yadong Liu et al.
Junjie Tang et al.
Pressure ulcers are a common issue in elderly and medically compromised individuals, posing significant challenges in healthcare. Human umbilical cord mesenchymal stem cells (HUMSCs) offer therapeutic benefits like inflammation modulation a...
Mesoporous cerium oxide nanoenzyme for Efficacious impeding tumor and metastasis via Conferring resistance to anoikis [0.03%]
中孔二氧化铈纳米酶通过赋予抗拒悬浮凋亡性有效阻碍肿瘤及其转移性研究
Yunhao Wang,Lei Ding,Juan Feng et al.
Yunhao Wang et al.
Tumor cells can survive when detached from the extracellular matrix or lose cell-to-cell connections, leading to a phenomenon known as anoikis resistance (AR). AR is closely associated with the metastasis and proliferation of tumor cells, e...
Glutamine synthetase accelerates re-endothelialization of vascular grafts by mitigating endothelial cell dysfunction in a rat model [0.03%]
谷氨酰胺合成酶通过减轻血管移植物中内皮细胞功能障碍促进其再内皮化：大鼠模型中的研究
Xinbo Wei,Li Wang,Zheng Xing et al.
Xinbo Wei et al.
Endothelial cell (EC) dysfunction within the aorta has long been recognized as a prominent contributor to the progression of atherosclerosis and the subsequent failure of vascular graft transplantation. However, the direct relationship betw...