Engineered endothelium model enables recapitulation of vascular function and early atherosclerosis development [0.03%]
工程血管内皮模型可再现血管功能和动脉粥样硬化早期发展情况
Avelino Dos Santos Da Costa,Kopych Vadym,Kwideok Park
Avelino Dos Santos Da Costa
Human health relies heavily on the vascular endothelium. Here, we propose a novel engineered endothelium model (EEM), which recapitulated both normal vascular function and pathology. An artificial basement membrane (aBM), where porous polyv...
Multifunctional sericin-based biomineralized nanoplatforms with immunomodulatory and angio/osteo-genic activity for accelerated bone regeneration in periodontitis [0.03%]
用于牙周炎加速骨再生的多功能丝素蛋白基生物矿化纳米平台具有免疫调节和促血管/成骨活性
Piaoye Ming,Bojiang Li,Qiumei Li et al.
Piaoye Ming et al.
Periodontitis is a chronic inflammation caused by dental plaque. It is characterized by the accumulation of excessive reactive oxygen species (ROS) and inflammatory mediators in the periodontal area. This affects the function of host cells,...
Mesenchymal stromal cells surface engineering for efficient hematopoietic reconstitution [0.03%]
高效造血重建的间充质基质细胞表面工程学
Huiyang Li,Lifei Ma,Ni Zhu et al.
Huiyang Li et al.
Mesenchymal stromal cells (MSCs) are believed to migrate to injury sites, release chemical attractants, and either recruit local stem cells or modulate the immune system positively. Although MSCs are highly desired for their potential to re...
An innovative strategy harnessing self-activating CAR-NK cells to mitigate TGF-β1-driven immune suppression [0.03%]
一种利用自激活的CAR-NK细胞克服TGF-β1介导的免疫抑制的创新策略
Seung Hun Shin,Young Eun Lee,Han-Na Yoon et al.
Seung Hun Shin et al.
The dysfunction of natural killer (NK) cells, mediated by transforming growth factor β1 (TGFβ1) within the tumor microenvironment, impedes antitumor therapy and contributes to poor clinical outcomes. Our study introduces self-activating c...
Exosomes from hypoxic urine-derived stem cells facilitate healing of diabetic wound by targeting SERPINE1 through miR-486-5p [0.03%]
缺氧尿源干细胞来源的外泌体通过miR-486-5p靶向SERPINE1促进糖尿病伤口愈合
Ming-Hui Fan,Xiu-Zhen Zhang,Yan-Lin Jiang et al.
Ming-Hui Fan et al.
Vascular pathologies and injuries are important factors for the delayed wound healing in diabetes. Previous studies have demonstrated that hypoxic environments could induce formation of new blood vessels by regulating intercellular communic...
PAR2 on oral cancer cells and nociceptors contributes to oral cancer pain that can be relieved by nanoparticle-encapsulated AZ3451 [0.03%]
PAR2在口腔癌细胞和痛觉感受器中的作用促进癌症疼痛，可被纳米颗粒包封的AZ3451缓解
Divya Bhansali,Nguyen H Tu,Kenji Inoue et al.
Divya Bhansali et al.
Oral cancer is notoriously painful. Activation of protease-activated receptor 2 (PAR2, encoded by F2RL1) by proteases in the cancer microenvironment is implicated in oral cancer pain. PAR2 is a G protein-coupled receptor (GPCR) expressed on...
Metal-organic framework-edaravone nanoparticles for radiotherapy-induced brain injury treatment [0.03%]
用于放射治疗引起的脑损伤治疗的金属有机骨架-乙氟黄纳米粒子
Xuejiao Li,Shiyuan Hua,Danni Zhong et al.
Xuejiao Li et al.
Cranial radiotherapy may cause damage to normal brain tissues and induce cognitive dysfunction, so developing an effective strategy to prevent radiotherapy-induced brain injury is essential. Metal-organic frameworks (MOFs) can be used as ve...
In situ photocrosslinkable hydrogel treats radiation-induced skin injury by ROS elimination and inflammation regulation [0.03%]
原位光交联水凝胶通过消除活性氧和调节炎症治疗放射性皮肤损伤
Jintao Shen,Wencheng Jiao,Junzhe Yang et al.
Jintao Shen et al.
The clinical management of radiation-induced skin injury (RSI) poses a significant challenge, primarily due to the acute damage caused by an overabundance of reactive oxygen species (ROS) and the ongoing inflammatory microenvironment. Here,...
Mitochondrial-uncoupling nanomedicine for self-heating and immunometabolism regulation in cancer cells [0.03%]
用于肿瘤细胞产热和免疫代谢调控的线粒体解偶联纳米药物
Zhe Yang,Ying Zhou,Xiaozhen Liu et al.
Zhe Yang et al.
Developing endogenous hyperthermia offers a promising strategy to address challenges with current exogenous hyperthermia techniques in clinics. Herein, a CD44-targeted and thermal-responsive nanocarrier was developed for the simultaneous de...
ROS-responsive injectable hydrogels loaded with exosomes carrying miR-4500 reverse liver fibrosis [0.03%]
响应ROS的可注射水凝胶负载携带miR-4500的外泌体逆转肝纤维化
Huili Yang,Wanshun Wang,Jiacong Xiao et al.
Huili Yang et al.
The reversal of liver fibrosis requires effective strategies to reduce oxidative stress and inhibition of hepatic stellate cell (HSC) activation. MiR-4500 regulates pathological angiogenesis and collagen mRNA stability, with the potential t...